Infracyanine green: Difference between revisions

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Infracyanine green (IFCG) is a cyanine dye used in medical diagnostics especially in ophthalmology. Unlike Indocyanine green (ICG) it is an iodine free dye.

Properties

Since IFCG is iodine free, instead of Indocyanine green, it is used in patients with iodine allergy.^[1] It has a peak spectral absorption between 600 nm to 700 nm.^[2] IFCG can be dissolved in 5% glucose solution instead of pure water, which makes it less cytotoxic in macular applications.^[3]

Uses

Infracyanine green stains the Internal Limiting Membrane layer of retina.^[4] IFCG is used to see structures to be removed during vitreoretinal surgery.^[5]

Toxicity

At a concentration above 0.05% IFCG may induce acute and chronic toxicities.^[5] But the retinal phototoxicity caused by IFCG is lesser compared to Indocyanine green.^[2]

References

^ Dithmar, S. (2008). Fluorescence angiography in ophthalmology. Frank G. Holz. Heidelberg: Springer Medizin Verlag. p. 3. ISBN 978-3-540-79401-1. OCLC 288578300.
^ ^a ^b Jackson, Timothy; Vote, Brendan; Knight, Bruce; El-Amir, Ahmed; Stanford, Miles; Marshall, John (2004-11-01). "Safety Testing of Infracyanine Green Using Retinal Pigment Epithelium and Glial Cell Cultures". Investigative ophthalmology & visual science. 45: 3697–703. doi:10.1167/iovs.04-0387.
^ Alander, Jarmo T.; Kaartinen, Ilkka; Laakso, Aki; Pätilä, Tommi; Spillmann, Thomas; Tuchin, Valery V.; Venermo, Maarit; Välisuo, Petri (2012-04-22). "A Review of Indocyanine Green Fluorescent Imaging in Surgery". International Journal of Biomedical Imaging. 2012: e940585. doi:10.1155/2012/940585. ISSN 1687-4188.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Chromovitrectomy - EyeWiki". eyewiki.aao.org. Retrieved 2022-04-10.
^ ^a ^b Kodjikian, L.; Richter, T.; Halberstadt, M.; Beby, F.; Flueckiger, F.; Boehnke, M.; Garweg, J. G. (2005-09). "Toxic effects of indocyanine green, infracyanine green, and trypan blue on the human retinal pigmented epithelium". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. 243 (9): 917–925. doi:10.1007/s00417-004-1121-6. ISSN 0721-832X. PMID 15834606. {{cite journal}}: Check date values in: |date= (help)

[1] Dithmar, S. (2008). Fluorescence angiography in ophthalmology. Frank G. Holz. Heidelberg: Springer Medizin Verlag. p. 3. ISBN 978-3-540-79401-1. OCLC 288578300.

[Jackson-2] Jackson, Timothy; Vote, Brendan; Knight, Bruce; El-Amir, Ahmed; Stanford, Miles; Marshall, John (2004-11-01). "Safety Testing of Infracyanine Green Using Retinal Pigment Epithelium and Glial Cell Cultures". Investigative ophthalmology & visual science. 45: 3697–703. doi:10.1167/iovs.04-0387.

[3] Alander, Jarmo T.; Kaartinen, Ilkka; Laakso, Aki; Pätilä, Tommi; Spillmann, Thomas; Tuchin, Valery V.; Venermo, Maarit; Välisuo, Petri (2012-04-22). "A Review of Indocyanine Green Fluorescent Imaging in Surgery". International Journal of Biomedical Imaging. 2012: e940585. doi:10.1155/2012/940585. ISSN 1687-4188.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[4] "Chromovitrectomy - EyeWiki". eyewiki.aao.org. Retrieved 2022-04-10.

[Kodjikian-5] Kodjikian, L.; Richter, T.; Halberstadt, M.; Beby, F.; Flueckiger, F.; Boehnke, M.; Garweg, J. G. (2005-09). "Toxic effects of indocyanine green, infracyanine green, and trypan blue on the human retinal pigmented epithelium". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. 243 (9): 917–925. doi:10.1007/s00417-004-1121-6. ISSN 0721-832X. PMID 15834606. {{cite journal}}: Check date values in: |date= (help)

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