Nathan Kuppermann: Difference between revisions

Add links
From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
Sarje12 (talk | contribs)
20 edits
Undid revision 1155666515 by Sarje12 (talk)
Added information and background about Nathan Kupperman's early research and notable contributions. Updated his Professional Service.
Line 13: Line 13:
He is both a pediatric emergency physician and clinical epidemiologist. Kuppermann has been a federally-funded investigator<ref>{{Cite journal|last1=Kuppermann|first1=Nathan|last2=Holmes|first2=James|title=DANGER: Developing the Next Generation of Emergency Medicine Researchers|url=https://grantome.com/grant/NIH/K12-HL108964-05|language=en}}</ref><ref>{{Cite journal|last1=Kuppermann|first1=Nathan|last2=Nishijima|first2=Daniel|title=Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children (TIC-TOC)|url=https://grantome.com/grant/NIH/R34-HL135214-02|language=en}}</ref><ref name="auto">{{Cite journal|last1=Holmes|first1=James|last2=Kuppermann|first2=Nathan|title=Validation of Decision Rules for CT Use in Children with Abdominal or Head Trauma|url=https://grantome.com/grant/NIH/R01-HD084674-05|language=en}}</ref> for many years and has particular interests in the clinical efficiency and utility of laboratory testing in the setting of the Pediatric Emergency Department.<ref>{{Cite journal|last1=Newgard|first1=Craig D.|last2=Lin|first2=Amber|last3=Olson|first3=Lenora M.|last4=Cook|first4=Jennifer N. B.|last5=Gausche-Hill|first5=Marianne|last6=Kuppermann|first6=Nathan|last7=Goldhaber-Fiebert|first7=Jeremy D.|last8=Malveau|first8=Susan|last9=Smith|first9=McKenna|last10=Dai|first10=Mengtao|last11=Nathens|first11=Avery B.|date=2021-09-01|title=Evaluation of Emergency Department Pediatric Readiness and Outcomes Among US Trauma Centers|journal=JAMA Pediatrics|volume=175|issue=9|pages=947–956|doi=10.1001/jamapediatrics.2021.1319|issn=2168-6211|pmc=8185631|pmid=34096991}}</ref> His research has specially emphasized the laboratory evaluation of young febrile children<ref>{{Cite journal|last1=Pantell|first1=Robert H.|last2=Roberts|first2=Kenneth B.|last3=Adams|first3=William G.|last4=Dreyer|first4=Benard P.|last5=Kuppermann|first5=Nathan|last6=O'Leary|first6=Sean T.|last7=Okechukwu|first7=Kymika|last8=Woods|first8=Charles R.|last9=SUBCOMMITTEE ON FEBRILE INFANTS|date=August 2021|title=Evaluation and Management of Well-Appearing Febrile Infants 8 to 60 Days Old|url=https://pubmed.ncbi.nlm.nih.gov/34281996/|journal=Pediatrics|volume=148|issue=2|pages=e2021052228|doi=10.1542/peds.2021-052228|issn=1098-4275|pmid=34281996|s2cid=236139548}}</ref>'','' evaluation of children at risk of diabetic ketoacidosis-related cerebral edema<ref>{{Cite journal|last=University of California, Davis|date=2018-06-19|others=Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|title=Fluid Therapy and Cerebral Injury in Pediatric Diabetic Ketoacidosis|url=https://clinicaltrials.gov/ct2/show/NCT01365793}}</ref> and laboratory and radiographic evaluation of the pediatric trauma patient.
He is both a pediatric emergency physician and clinical epidemiologist. Kuppermann has been a federally-funded investigator<ref>{{Cite journal|last1=Kuppermann|first1=Nathan|last2=Holmes|first2=James|title=DANGER: Developing the Next Generation of Emergency Medicine Researchers|url=https://grantome.com/grant/NIH/K12-HL108964-05|language=en}}</ref><ref>{{Cite journal|last1=Kuppermann|first1=Nathan|last2=Nishijima|first2=Daniel|title=Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children (TIC-TOC)|url=https://grantome.com/grant/NIH/R34-HL135214-02|language=en}}</ref><ref name="auto">{{Cite journal|last1=Holmes|first1=James|last2=Kuppermann|first2=Nathan|title=Validation of Decision Rules for CT Use in Children with Abdominal or Head Trauma|url=https://grantome.com/grant/NIH/R01-HD084674-05|language=en}}</ref> for many years and has particular interests in the clinical efficiency and utility of laboratory testing in the setting of the Pediatric Emergency Department.<ref>{{Cite journal|last1=Newgard|first1=Craig D.|last2=Lin|first2=Amber|last3=Olson|first3=Lenora M.|last4=Cook|first4=Jennifer N. B.|last5=Gausche-Hill|first5=Marianne|last6=Kuppermann|first6=Nathan|last7=Goldhaber-Fiebert|first7=Jeremy D.|last8=Malveau|first8=Susan|last9=Smith|first9=McKenna|last10=Dai|first10=Mengtao|last11=Nathens|first11=Avery B.|date=2021-09-01|title=Evaluation of Emergency Department Pediatric Readiness and Outcomes Among US Trauma Centers|journal=JAMA Pediatrics|volume=175|issue=9|pages=947–956|doi=10.1001/jamapediatrics.2021.1319|issn=2168-6211|pmc=8185631|pmid=34096991}}</ref> His research has specially emphasized the laboratory evaluation of young febrile children<ref>{{Cite journal|last1=Pantell|first1=Robert H.|last2=Roberts|first2=Kenneth B.|last3=Adams|first3=William G.|last4=Dreyer|first4=Benard P.|last5=Kuppermann|first5=Nathan|last6=O'Leary|first6=Sean T.|last7=Okechukwu|first7=Kymika|last8=Woods|first8=Charles R.|last9=SUBCOMMITTEE ON FEBRILE INFANTS|date=August 2021|title=Evaluation and Management of Well-Appearing Febrile Infants 8 to 60 Days Old|url=https://pubmed.ncbi.nlm.nih.gov/34281996/|journal=Pediatrics|volume=148|issue=2|pages=e2021052228|doi=10.1542/peds.2021-052228|issn=1098-4275|pmid=34281996|s2cid=236139548}}</ref>'','' evaluation of children at risk of diabetic ketoacidosis-related cerebral edema<ref>{{Cite journal|last=University of California, Davis|date=2018-06-19|others=Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|title=Fluid Therapy and Cerebral Injury in Pediatric Diabetic Ketoacidosis|url=https://clinicaltrials.gov/ct2/show/NCT01365793}}</ref> and laboratory and radiographic evaluation of the pediatric trauma patient.


== Early Research ==
⚫
==Professional service==
Kuppermann’s early research addressed the identification of young children presenting to the emergency department (ED) with infectious emergencies.<ref>{{Cite journal |last=Kuppermann |first=Nathan |last2=Malley |first2=Richard |last3=Inkelis |first3=Stanley H. |last4=Fleisher |first4=Gary R. |date=1999-02-01 |title=Clinical and Hematologic Features Do Not Reliably Identify Children With Unsuspected Meningococcal Disease |url=http://dx.doi.org/10.1542/peds.103.2.e20 |journal=Pediatrics |volume=103 |issue=2 |pages=e20–e20 |doi=10.1542/peds.103.2.e20 |issn=1098-4275}}</ref> These studies focused on distinguishing young febrile children with serious bacterial infections (SBIs) from those with viral illnesses.<ref>{{Cite journal |last=Nigrovic |first=Lise E. |date=2007-01-03 |title=Clinical Prediction Rule for Identifying Children With Cerebrospinal Fluid Pleocytosis at Very Low Risk of Bacterial Meningitis |url=http://dx.doi.org/10.1001/jama.297.1.52 |journal=JAMA |volume=297 |issue=1 |pages=52 |doi=10.1001/jama.297.1.52 |issn=0098-7484}}</ref><ref>{{Cite journal |last=Mahajan |first=Prashant |last2=Kuppermann |first2=Nathan |last3=Mejias |first3=Asuncion |last4=Suarez |first4=Nicolas |last5=Chaussabel |first5=Damien |last6=Casper |first6=T. Charles |last7=Smith |first7=Bennett |last8=Alpern |first8=Elizabeth R. |last9=Anders |first9=Jennifer |last10=Atabaki |first10=Shireen M. |last11=Bennett |first11=Jonathan E. |last12=Blumberg |first12=Stephen |last13=Bonsu |first13=Bema |last14=Borgialli |first14=Dominic |last15=Brayer |first15=Anne |date=2016-08-23 |title=Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122927/ |journal=JAMA |volume=316 |issue=8 |pages=846–857 |doi=10.1001/jama.2016.9207 |issn=0098-7484 |pmc=5122927 |pmid=27552618}}</ref> His studies derived and validated prediction rules in order to aid ED clinicians in risk stratifying infants at low and high-risk of SBIs, and his studies centered on meningitis, bacteremia, and urinary tract infections.<ref>{{Cite journal |last=Kuppermann |first=Nathan |last2=Dayan |first2=Peter S. |last3=Levine |first3=Deborah A. |last4=Vitale |first4=Melissa |last5=Tzimenatos |first5=Leah |last6=Tunik |first6=Michael G. |last7=Saunders |first7=Mary |last8=Ruddy |first8=Richard M. |last9=Roosevelt |first9=Genie |last10=Rogers |first10=Alexander J. |last11=Powell |first11=Elizabeth C. |last12=Nigrovic |first12=Lise E. |last13=Muenzer |first13=Jared |last14=Linakis |first14=James G. |last15=Grisanti |first15=Kathleen |date=2019-4 |title=A Clinical Prediction Rule to Identify Febrile Infants 60 Days and Younger at Low Risk for Serious Bacterial Infections |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450281/ |journal=JAMA Pediatrics |volume=173 |issue=4 |pages=342–351 |doi=10.1001/jamapediatrics.2018.5501 |issn=2168-6203 |pmc=6450281 |pmid=30776077}}</ref> 
⚫
Kuppermann served as Chair of the Steering Committee of the Pediatric Emergency Care Applied Research Network (PECARN) since its inception in 2001 until late in 2008. This network is funded by HRSA/MCHB and EMSC and consists of 22 geographically and demographically diverse hospital pediatric emergency departments which evaluate ~ 900,000 children annually.  Most recently, he completed a 25-center study of 45,000 head injured children in PECARN to create and validate a decision rule for emergency neuroimaging of these children<ref>{{Cite web|title=Imaging Initiative|url=https://www.acep.org/globalassets/uploads/uploaded-files/acep/quality/avoidable-imaging-webinars/avoidable-imaging-initiative_nov.pdf|url-status=live}}</ref><ref>{{Cite journal|last1=Osmond|first1=Martin H.|last2=Klassen|first2=Terry P.|last3=Wells|first3=George A.|last4=Davidson|first4=Jennifer|last5=Correll|first5=Rhonda|last6=Boutis|first6=Kathy|last7=Joubert|first7=Gary|last8=Gouin|first8=Serge|last9=Khangura|first9=Simi|last10=Turner|first10=Troy|last11=Belanger|first11=Francois|date=2018-07-09|title=Validation and refinement of a clinical decision rule for the use of computed tomography in children with minor head injury in the emergency department|url=https://www.cmaj.ca/content/190/27/e816|journal=CMAJ|language=en|volume=190|issue=27|pages=E816–E822|doi=10.1503/cmaj.170406|issn=0820-3946|pmid=29986857|pmc=6041249}}</ref><ref name="auto"/>

== Notable Contributions to Research ==
Kuppermann has extensive experience performing large, multicenter randomized controlled trials and observational studies pertaining to pediatric trauma, and he was the founding chair of the Pediatric Emergency Applied Research Network (PECARN).

Kuppermann has been studying trauma in children for over 20 years and has been particularly active in research pertaining to traumatic brain injuries (TBI) in children.<ref>{{Cite journal |last=Stockman |first=J.A. |date=2011-01 |title=Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study |url=http://dx.doi.org/10.1016/s0084-3954(10)79686-x |journal=Yearbook of Pediatrics |volume=2011 |pages=392–395 |doi=10.1016/s0084-3954(10)79686-x |issn=0084-3954}}</ref> In particular, Kuppermann has been studying ways to more efficiently use CT scans in children after trauma.<ref>{{Cite journal |last=Stockman |first=J.A. |date=2011-01 |title=Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study |url=http://dx.doi.org/10.1016/s0084-3954(10)79686-x |journal=Yearbook of Pediatrics |volume=2011 |pages=392–395 |doi=10.1016/s0084-3954(10)79686-x |issn=0084-3954}}</ref> He has served as senior investigator/co-PI in research pertaining to pediatric abdominal trauma <ref>{{Cite journal |last=Holmes |first=James F. |last2=Lillis |first2=Kathleen |last3=Monroe |first3=David |last4=Borgialli |first4=Dominic |last5=Kerrey |first5=Benjamin T. |last6=Mahajan |first6=Prashant |last7=Adelgais |first7=Kathleen |last8=Ellison |first8=Angela M. |last9=Yen |first9=Kenneth |last10=Atabaki |first10=Shireen |last11=Menaker |first11=Jay |last12=Bonsu |first12=Bema |last13=Quayle |first13=Kimberly S. |last14=Garcia |first14=Madelyn |last15=Rogers |first15=Alexander |date=2013-08 |title=Identifying Children at Very Low Risk of Clinically Important Blunt Abdominal Injuries |url=http://dx.doi.org/10.1016/j.annemergmed.2012.11.009 |journal=Annals of Emergency Medicine |volume=62 |issue=2 |pages=107–116.e2 |doi=10.1016/j.annemergmed.2012.11.009 |issn=0196-0644}}</ref>through which he derived a highly accurate prediction rule for CT use, the largest of which enrolled >12,000 children with abdominal trauma.

His other notable research pertains to diabetic ketoacidosis (DKA) in children,<ref>{{Cite journal |last=Kuppermann |first=Nathan |last2=Ghetti |first2=Simona |last3=Schunk |first3=Jeff E. |last4=Stoner |first4=Michael J. |last5=Rewers |first5=Arleta |last6=McManemy |first6=Julie K. |last7=Myers |first7=Sage R. |last8=Nigrovic |first8=Lise E. |last9=Garro |first9=Aris |last10=Brown |first10=Kathleen M. |last11=Quayle |first11=Kimberly S. |last12=Trainor |first12=Jennifer L. |last13=Tzimenatos |first13=Leah |last14=Bennett |first14=Jonathan E. |last15=DePiero |first15=Andrew D. |date=2018-06-14 |title=Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051773/ |journal=The New England journal of medicine |volume=378 |issue=24 |pages=2275–2287 |doi=10.1056/NEJMoa1716816 |issn=0028-4793 |pmc=6051773 |pmid=29897851}}</ref><ref>{{Cite journal |last=Glaser |first=Nicole S. |last2=Wootton-Gorges |first2=Sandra L. |last3=Buonocore |first3=Michael H. |last4=Tancredi |first4=Daniel J. |last5=Marcin |first5=James P. |last6=Caltagirone |first6=Ryan |last7=Lee |first7=Yvonne |last8=Murphy |first8=Christopher |last9=Kuppermann |first9=Nathan |date=2013-1 |title=Subclinical Cerebral Edema in Children With Diabetic Ketoacidosis Randomized to 2 Different Rehydration Protocols |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529948/ |journal=Pediatrics |volume=131 |issue=1 |pages=e73–e80 |doi=10.1542/peds.2012-1049 |issn=0031-4005 |pmc=3529948 |pmid=23230065}}</ref><ref>{{Cite journal |last=Myers |first=Sage R. |last2=Glaser |first2=Nicole S. |last3=Trainor |first3=Jennifer L. |last4=Nigrovic |first4=Lise E. |last5=Garro |first5=Aris |last6=Tzimenatos |first6=Leah |last7=Quayle |first7=Kimberly S. |last8=Kwok |first8=Maria Y. |last9=Rewers |first9=Arleta |last10=Stoner |first10=Michael J. |last11=Schunk |first11=Jeff E. |last12=McManemy |first12=Julie K. |last13=Brown |first13=Kathleen M. |last14=DePiero |first14=Andrew D. |last15=Olsen |first15=Cody S. |date=2020-12-04 |title=Frequency and Risk Factors of Acute Kidney Injury During Diabetic Ketoacidosis in Children and Association With Neurocognitive Outcomes |url=http://dx.doi.org/10.1001/jamanetworkopen.2020.25481 |journal=JAMA Network Open |volume=3 |issue=12 |pages=e2025481 |doi=10.1001/jamanetworkopen.2020.25481 |issn=2574-3805}}</ref> and he has been involved in this research for over 20 years. He has served as a PI and Primary co-I on several extramural grants related to DKA and cerebral injury/edema in children, and one of his earliest research collaborations of the topic resulted in a highly-cited publication in the New England Journal of Medicine. <ref>{{Cite journal |last=Kuppermann |first=Nathan |last2=Ghetti |first2=Simona |last3=Schunk |first3=Jeff E. |last4=Stoner |first4=Michael J. |last5=Rewers |first5=Arleta |last6=McManemy |first6=Julie K. |last7=Myers |first7=Sage R. |last8=Nigrovic |first8=Lise E. |last9=Garro |first9=Aris |last10=Brown |first10=Kathleen M. |last11=Quayle |first11=Kimberly S. |last12=Trainor |first12=Jennifer L. |last13=Tzimenatos |first13=Leah |last14=Bennett |first14=Jonathan E. |last15=DePiero |first15=Andrew D. |date=2018-06-14 |title=Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051773/ |journal=The New England journal of medicine |volume=378 |issue=24 |pages=2275–2287 |doi=10.1056/NEJMoa1716816 |issn=0028-4793 |pmc=6051773 |pmid=29897851}}</ref>

== Current Research ==
Most currently, Kuppermann has investigated novel biomarkers and measured the host response to distinguish viral from bacterial infections in young febrile infants.<ref>{{Cite journal |last=Kuppermann |first=Nathan |last2=Dayan |first2=Peter S. |last3=Levine |first3=Deborah A. |last4=Vitale |first4=Melissa |last5=Tzimenatos |first5=Leah |last6=Tunik |first6=Michael G. |last7=Saunders |first7=Mary |last8=Ruddy |first8=Richard M. |last9=Roosevelt |first9=Genie |last10=Rogers |first10=Alexander J. |last11=Powell |first11=Elizabeth C. |last12=Nigrovic |first12=Lise E. |last13=Muenzer |first13=Jared |last14=Linakis |first14=James G. |last15=Grisanti |first15=Kathleen |date=2019-4 |title=A Clinical Prediction Rule to Identify Febrile Infants 60 Days and Younger at Low Risk for Serious Bacterial Infections |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450281/ |journal=JAMA Pediatrics |volume=173 |issue=4 |pages=342–351 |doi=10.1001/jamapediatrics.2018.5501 |issn=2168-6203 |pmc=6450281 |pmid=30776077}}</ref>

⚫
==Professional Service==
Kuppermann has been a leader in multicenter research in emergency services for children, and he has worked to increase the evidence base in pediatric emergency medicine. He served as the Chair of the Pediatric Emergency Medicine Collaborative Research Committee (PEMCRC) of the American Academy of Pediatrics from 1996-2000. Through this committee, he conducted various research studies in which thousands of children were enrolled.

⚫
Kuppermann also served as founding Chair of the Steering Committee of the Pediatric Emergency Care Applied Research Network (PECARN) since its inception in 2001 until late in 2008. This network is funded by HRSA/MCHB and EMSC and consists of 22 geographically and demographically diverse hospital pediatric emergency departments which evaluate ~ 900,000 children annually.  Most recently, he completed a 25-center study of 45,000 head injured children in PECARN to create and validate a decision rule for emergency neuroimaging of these children.<ref>{{Cite web|title=Imaging Initiative|url=https://www.acep.org/globalassets/uploads/uploaded-files/acep/quality/avoidable-imaging-webinars/avoidable-imaging-initiative_nov.pdf|url-status=live}}</ref><ref>{{Cite journal|last1=Osmond|first1=Martin H.|last2=Klassen|first2=Terry P.|last3=Wells|first3=George A.|last4=Davidson|first4=Jennifer|last5=Correll|first5=Rhonda|last6=Boutis|first6=Kathy|last7=Joubert|first7=Gary|last8=Gouin|first8=Serge|last9=Khangura|first9=Simi|last10=Turner|first10=Troy|last11=Belanger|first11=Francois|date=2018-07-09|title=Validation and refinement of a clinical decision rule for the use of computed tomography in children with minor head injury in the emergency department|url=https://www.cmaj.ca/content/190/27/e816|journal=CMAJ|language=en|volume=190|issue=27|pages=E816–E822|doi=10.1503/cmaj.170406|issn=0820-3946|pmid=29986857|pmc=6041249}}</ref><ref name="auto" /> Since its creation, PECARN has published more than 160 peer-reviewed publications and secured more than $120 million in extramural funding,<ref>{{Cite journal |last=Tzimenatos |first=Leah |last2=Kim |first2=Emily |last3=Kuppermann |first3=Nathan |date=2015-01 |title=The Pediatric Emergency Care Applied Research Network |url=http://dx.doi.org/10.1097/pec.0000000000000303 |journal=Pediatric Emergency Care |volume=31 |issue=1 |pages=70–76 |doi=10.1097/pec.0000000000000303 |issn=0749-5161}}</ref> and from 2019-2023, Kuppermann was refunded to participate in PECARN with a $2.8 million award. As a leader of PECARN, his work has helped shape the future concerning pediatric emergency care and advanced the ability to perform large-scale, multicenter research across the country.<ref>{{Cite journal |date=2008-06-28 |title=The Pediatric Emergency Care Applied Research Network (PECARN): Rationale, Development, and First Steps* |url=http://dx.doi.org/10.1111/j.1553-2712.2003.tb00053.x |journal=Academic Emergency Medicine |volume=10 |issue=6 |pages=661–668 |doi=10.1111/j.1553-2712.2003.tb00053.x |issn=1069-6563}}</ref>


== Awards and Honors ==
== Awards and Honors ==
Line 28: Line 43:


Distinguished Professor, UC Davis School of Medicine(2018)
Distinguished Professor, UC Davis School of Medicine(2018)

Inaugural winner of SAEM Scientific Mentoring Award in Pediatric Emergency Medicine(2017)

Dean’s Team Award for Excellence in Mentoring, UC Davis School of Medicine(2017)


UC Davis School of Medicine Research Award(2016)<ref>https://health.ucdavis.edu/medschool/somsenate/pdf/school-of-medicine-research-award-2023.pdf</ref>
UC Davis School of Medicine Research Award(2016)<ref>https://health.ucdavis.edu/medschool/somsenate/pdf/school-of-medicine-research-award-2023.pdf</ref>

Best Scientific Abstract, American Academy of Pediatrics Section on Emergency Medicine(2015)


American College of Emergency Physicians (ACEP) EBSCO/PEMSoft Achievement Award(2015)<ref>{{Cite web |title=Emergency Physician Nathan Kuppermann, MD, MPH, Wins Award for Significant Contributions to Pediatric Emergency Medicine - News {{!}} EBSCO |url=https://www.ebsco.com/news-center/press-releases/emergency-physician-nathan-kuppermann-md-mph-wins-award-significant |access-date=2023-05-10 |website=www.ebsco.com |language=en}}</ref>
American College of Emergency Physicians (ACEP) EBSCO/PEMSoft Achievement Award(2015)<ref>{{Cite web |title=Emergency Physician Nathan Kuppermann, MD, MPH, Wins Award for Significant Contributions to Pediatric Emergency Medicine - News {{!}} EBSCO |url=https://www.ebsco.com/news-center/press-releases/emergency-physician-nathan-kuppermann-md-mph-wins-award-significant |access-date=2023-05-10 |website=www.ebsco.com |language=en}}</ref>

Ludwig-Seidel Award, American Academy of Pediatrics(2012)<ref>{{Cite web |last=Staff |first=Fire Engineering |date=2011-10-18 |title=American College of Emergency Physicians Recognizes Excellence in Emergency Medicine |url=https://www.fireengineering.com/fire-ems/american-college-of-emergency-physicians-recognizes-excellence-in-emergency-medicine/ |access-date=2023-05-19 |website=Fire Engineering: Firefighter Training and Fire Service News, Rescue |language=en-US}}</ref>

Best Scientific Abstract, American Academy of Pediatrics Section on Emergency Medicine(2012)

Best Scientific Paper, American Academy of Pediatrics Section on Emergency Medicine(2011)

American College of Emergency Physicians Outstanding Research Award(2011)<ref name=":0">{{Cite web |date=2013-10-24 |title=Nov-Dec 2011 Newsletter_0 by Society for Academic Emergency Medicine - Issuu |url=https://issuu.com/saemonline/docs/nov-dec-2011-newsletter_0 |access-date=2023-05-19 |website=issuu.com |language=en}}</ref>

Elected to the National Academy of Medicine(Institute of Medicine)(2010)<ref name=":0" />

EMSC National Hero’s Award: Outstanding Research Project(2010)<ref>{{Cite news |last=Zuspan |first=SAlly |date=2010 |title=PECARN Newsletter |url=https://pecarn.org/wp-content/uploads/2021/02/PECARNNewsletterFall2010CDMCC.pdf}}</ref>

Society for Academic Emergency Medicine (SAEM) Excellence in Research Award(2010)<ref>{{Cite web |title=Past Award Winners |url=https://www.saem.org/research/saem-awards/past-award-winners |access-date=2023-05-19 |website=Default |language=en}}</ref>

Miller-Sarkin Mentoring award, Academic Pediatric Association(2009)<ref>{{Cite web |title=Miller-Sarkin Mentoring Award |url=https://www.academicpeds.org/award/miller-sarkin-award/ |access-date=2023-05-19 |website=Academic Pediatric Association |language=en-US}}</ref>

Dean’s Excellence in Research Award, UC Davis School of Medicine(2008)<ref>{{Cite web |title=Faculty Development-Deans' Award for Excellence List of Recipients |url=https://health.ucdavis.edu/facultydev/Awards/list_deansawardforexcellence.html |access-date=2023-05-19 |website=health.ucdavis.edu}}</ref>

Willis Wingert Award (mentor for Best Scientific Paper by a Trainee), EM, AAP(2008)

Pediatric Emergency Medicine and Critical Care Research Award, AAP(2008)

Emergency Medical Service for Children (EMSC) National Hero’s Award: Outstanding Research(2007)<ref>{{Cite web |title=SeniorAdvisoryTeam |url=https://www.impactscollaborative.com/senior-advisors-1 |access-date=2023-05-19 |website=ImPACTS |language=en}}</ref>

Outstanding Contribution to Faculty Development and Diversity, UC Davis School of Med(2007)

Pediatric Emergency Medicine and Critical Care Research Award(2006)


Dean’s Team Award for Excellence in Mentoring, UC Davis School of Medicine(2003)<ref>{{Cite web |title=Faculty Development - Deans' Award for Excellence in Mentoring List |url=https://health.ucdavis.edu/facultydev/Awards/list_deansmentoringaward.html |access-date=2023-05-10 |website=health.ucdavis.edu}}</ref>
Dean’s Team Award for Excellence in Mentoring, UC Davis School of Medicine(2003)<ref>{{Cite web |title=Faculty Development - Deans' Award for Excellence in Mentoring List |url=https://health.ucdavis.edu/facultydev/Awards/list_deansmentoringaward.html |access-date=2023-05-10 |website=health.ucdavis.edu}}</ref>

Fulbright Distinguished Scholar, U.K.(2003)<ref>{{Cite web |title=University of London, London School of Hygiene and Tropical Medicine {{!}} Fulbright Scholar Program |url=https://fulbrightscholars.org/institution/university-london-london-school-hygiene-and-tropical-medicine |access-date=2023-05-19 |website=fulbrightscholars.org}}</ref>

Pediatric Emergency Medicine and Critical Care Research Award(2002)

Outstanding Consultant, Annals of Emergency Medicine(2000)

Academic Teacher of the Year Award, Emergency Medicine, UC Davis School of Medicine(2000)

Outstanding Faculty Clinical Instructor, UC Davis School of Medicine(1998)

The Role Model Award, Department of Pediatrics, UC Davis School of Medicine(1997, 1999)

Pediatric Emergency Medicine and Critical Care Research Award, AAP(1996)

Fellow’s Teaching Award, Children’s Hospital, Boston, MA(1992)

Outstanding Teaching Resident Award, Dept of Pediatrics, Harbor-UCLA, Torrance, CA(1987, 1989)

Alpha Omega Alpha Medical Honor Society, UC San Francisco School of Medicine(1985)


== References ==
== References ==

Revision as of 05:53, 19 May 2023

Nathan Kuppermann

Nathan Kuppermann is an American pediatrician and professor in the Departments of Emergency Medicine and Pediatrics at UC Davis School of Medicine.[1] where he holds the Bo Tomas Brofeldt Endowed Chair.[2] He is the former chair of the International Pediatric Emergency Research Network (PERN) and is a Member of the National Academy of Medicine.

Education

Kuppermann received his B.SC in Biology at Stanford University.[3] He completed his Doctorate in Medicine at the University of California, San Francisco School of Medicine[4] and continued on to Harvard University, School of Public Health for his Masters in Public Health[5]

Academic work

He is both a pediatric emergency physician and clinical epidemiologist. Kuppermann has been a federally-funded investigator[6][7][8] for many years and has particular interests in the clinical efficiency and utility of laboratory testing in the setting of the Pediatric Emergency Department.[9] His research has specially emphasized the laboratory evaluation of young febrile children[10], evaluation of children at risk of diabetic ketoacidosis-related cerebral edema[11] and laboratory and radiographic evaluation of the pediatric trauma patient.

Early Research

Kuppermann’s early research addressed the identification of young children presenting to the emergency department (ED) with infectious emergencies.[12] These studies focused on distinguishing young febrile children with serious bacterial infections (SBIs) from those with viral illnesses.[13][14] His studies derived and validated prediction rules in order to aid ED clinicians in risk stratifying infants at low and high-risk of SBIs, and his studies centered on meningitis, bacteremia, and urinary tract infections.[15] 

Notable Contributions to Research

Kuppermann has extensive experience performing large, multicenter randomized controlled trials and observational studies pertaining to pediatric trauma, and he was the founding chair of the Pediatric Emergency Applied Research Network (PECARN).

Kuppermann has been studying trauma in children for over 20 years and has been particularly active in research pertaining to traumatic brain injuries (TBI) in children.[16] In particular, Kuppermann has been studying ways to more efficiently use CT scans in children after trauma.[17] He has served as senior investigator/co-PI in research pertaining to pediatric abdominal trauma [18]through which he derived a highly accurate prediction rule for CT use, the largest of which enrolled >12,000 children with abdominal trauma.

His other notable research pertains to diabetic ketoacidosis (DKA) in children,[19][20][21] and he has been involved in this research for over 20 years. He has served as a PI and Primary co-I on several extramural grants related to DKA and cerebral injury/edema in children, and one of his earliest research collaborations of the topic resulted in a highly-cited publication in the New England Journal of Medicine. [22]

Current Research

Most currently, Kuppermann has investigated novel biomarkers and measured the host response to distinguish viral from bacterial infections in young febrile infants.[23]

Professional Service

Kuppermann has been a leader in multicenter research in emergency services for children, and he has worked to increase the evidence base in pediatric emergency medicine. He served as the Chair of the Pediatric Emergency Medicine Collaborative Research Committee (PEMCRC) of the American Academy of Pediatrics from 1996-2000. Through this committee, he conducted various research studies in which thousands of children were enrolled.

Kuppermann also served as founding Chair of the Steering Committee of the Pediatric Emergency Care Applied Research Network (PECARN) since its inception in 2001 until late in 2008. This network is funded by HRSA/MCHB and EMSC and consists of 22 geographically and demographically diverse hospital pediatric emergency departments which evaluate ~ 900,000 children annually.  Most recently, he completed a 25-center study of 45,000 head injured children in PECARN to create and validate a decision rule for emergency neuroimaging of these children.[24][25][8] Since its creation, PECARN has published more than 160 peer-reviewed publications and secured more than $120 million in extramural funding,[26] and from 2019-2023, Kuppermann was refunded to participate in PECARN with a $2.8 million award. As a leader of PECARN, his work has helped shape the future concerning pediatric emergency care and advanced the ability to perform large-scale, multicenter research across the country.[27]

Awards and Honors

Maureen Andrew Mentor Award, Society for Pediatric Research(2022)[28]

Hibbard Williams Extraordinary Achievement Award(2020)[29]

Faculty Distinguished Research Award, UC Davis(2020)[30]

Chancellor’s Departmental Achievement Award for Diversity and Community for Emergency Medicine(2020)[31]

Dean’s Team Award for Excellence for the Pediatric Emergency Care Applied Research Network (PECARN), UC Davis School of Medicine(2018)[32]

Distinguished Professor, UC Davis School of Medicine(2018)

UC Davis School of Medicine Research Award(2016)[33]

American College of Emergency Physicians (ACEP) EBSCO/PEMSoft Achievement Award(2015)[34]

Dean’s Team Award for Excellence in Mentoring, UC Davis School of Medicine(2003)[35]

References

  1. ^ "Professor Kuppermann".{{cite web}}: CS1 maint: url-status (link)
  2. ^ "University of California Davis - WikEM". medbox.iiab.me. Retrieved 2022-01-12.
  3. ^ "physicians/ucdavis".{{cite web}}: CS1 maint: url-status (link)
  4. ^ "webmd".{{cite web}}: CS1 maint: url-status (link)
  5. ^ "ucdavis".{{cite web}}: CS1 maint: url-status (link)
  6. ^ Kuppermann, Nathan; Holmes, James. "DANGER: Developing the Next Generation of Emergency Medicine Researchers". {{cite journal}}: Cite journal requires |journal= (help)
  7. ^ Kuppermann, Nathan; Nishijima, Daniel. "Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children (TIC-TOC)". {{cite journal}}: Cite journal requires |journal= (help)
  8. ^ a b Holmes, James; Kuppermann, Nathan. "Validation of Decision Rules for CT Use in Children with Abdominal or Head Trauma". {{cite journal}}: Cite journal requires |journal= (help)
  9. ^ Newgard, Craig D.; Lin, Amber; Olson, Lenora M.; Cook, Jennifer N. B.; Gausche-Hill, Marianne; Kuppermann, Nathan; Goldhaber-Fiebert, Jeremy D.; Malveau, Susan; Smith, McKenna; Dai, Mengtao; Nathens, Avery B. (2021-09-01). "Evaluation of Emergency Department Pediatric Readiness and Outcomes Among US Trauma Centers". JAMA Pediatrics. 175 (9): 947–956. doi:10.1001/jamapediatrics.2021.1319. ISSN 2168-6211. PMC 8185631. PMID 34096991.
  10. ^ Pantell, Robert H.; Roberts, Kenneth B.; Adams, William G.; Dreyer, Benard P.; Kuppermann, Nathan; O'Leary, Sean T.; Okechukwu, Kymika; Woods, Charles R.; SUBCOMMITTEE ON FEBRILE INFANTS (August 2021). "Evaluation and Management of Well-Appearing Febrile Infants 8 to 60 Days Old". Pediatrics. 148 (2): e2021052228. doi:10.1542/peds.2021-052228. ISSN 1098-4275. PMID 34281996. S2CID 236139548.
  11. ^ University of California, Davis (2018-06-19). "Fluid Therapy and Cerebral Injury in Pediatric Diabetic Ketoacidosis". Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). {{cite journal}}: Cite journal requires |journal= (help)
  12. ^ Kuppermann, Nathan; Malley, Richard; Inkelis, Stanley H.; Fleisher, Gary R. (1999-02-01). "Clinical and Hematologic Features Do Not Reliably Identify Children With Unsuspected Meningococcal Disease". Pediatrics. 103 (2): e20–e20. doi:10.1542/peds.103.2.e20. ISSN 1098-4275.
  13. ^ Nigrovic, Lise E. (2007-01-03). "Clinical Prediction Rule for Identifying Children With Cerebrospinal Fluid Pleocytosis at Very Low Risk of Bacterial Meningitis". JAMA. 297 (1): 52. doi:10.1001/jama.297.1.52. ISSN 0098-7484.
  14. ^ Mahajan, Prashant; Kuppermann, Nathan; Mejias, Asuncion; Suarez, Nicolas; Chaussabel, Damien; Casper, T. Charles; Smith, Bennett; Alpern, Elizabeth R.; Anders, Jennifer; Atabaki, Shireen M.; Bennett, Jonathan E.; Blumberg, Stephen; Bonsu, Bema; Borgialli, Dominic; Brayer, Anne (2016-08-23). "Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger". JAMA. 316 (8): 846–857. doi:10.1001/jama.2016.9207. ISSN 0098-7484. PMC 5122927. PMID 27552618.
  15. ^ Kuppermann, Nathan; Dayan, Peter S.; Levine, Deborah A.; Vitale, Melissa; Tzimenatos, Leah; Tunik, Michael G.; Saunders, Mary; Ruddy, Richard M.; Roosevelt, Genie; Rogers, Alexander J.; Powell, Elizabeth C.; Nigrovic, Lise E.; Muenzer, Jared; Linakis, James G.; Grisanti, Kathleen (2019-4). "A Clinical Prediction Rule to Identify Febrile Infants 60 Days and Younger at Low Risk for Serious Bacterial Infections". JAMA Pediatrics. 173 (4): 342–351. doi:10.1001/jamapediatrics.2018.5501. ISSN 2168-6203. PMC 6450281. PMID 30776077. {{cite journal}}: Check date values in: |date= (help)
  16. ^ Stockman, J.A. (2011-01). "Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study". Yearbook of Pediatrics. 2011: 392–395. doi:10.1016/s0084-3954(10)79686-x. ISSN 0084-3954. {{cite journal}}: Check date values in: |date= (help)
  17. ^ Stockman, J.A. (2011-01). "Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study". Yearbook of Pediatrics. 2011: 392–395. doi:10.1016/s0084-3954(10)79686-x. ISSN 0084-3954. {{cite journal}}: Check date values in: |date= (help)
  18. ^ Holmes, James F.; Lillis, Kathleen; Monroe, David; Borgialli, Dominic; Kerrey, Benjamin T.; Mahajan, Prashant; Adelgais, Kathleen; Ellison, Angela M.; Yen, Kenneth; Atabaki, Shireen; Menaker, Jay; Bonsu, Bema; Quayle, Kimberly S.; Garcia, Madelyn; Rogers, Alexander (2013-08). "Identifying Children at Very Low Risk of Clinically Important Blunt Abdominal Injuries". Annals of Emergency Medicine. 62 (2): 107–116.e2. doi:10.1016/j.annemergmed.2012.11.009. ISSN 0196-0644. {{cite journal}}: Check date values in: |date= (help)
  19. ^ Kuppermann, Nathan; Ghetti, Simona; Schunk, Jeff E.; Stoner, Michael J.; Rewers, Arleta; McManemy, Julie K.; Myers, Sage R.; Nigrovic, Lise E.; Garro, Aris; Brown, Kathleen M.; Quayle, Kimberly S.; Trainor, Jennifer L.; Tzimenatos, Leah; Bennett, Jonathan E.; DePiero, Andrew D. (2018-06-14). "Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis". The New England journal of medicine. 378 (24): 2275–2287. doi:10.1056/NEJMoa1716816. ISSN 0028-4793. PMC 6051773. PMID 29897851.
  20. ^ Glaser, Nicole S.; Wootton-Gorges, Sandra L.; Buonocore, Michael H.; Tancredi, Daniel J.; Marcin, James P.; Caltagirone, Ryan; Lee, Yvonne; Murphy, Christopher; Kuppermann, Nathan (2013-1). "Subclinical Cerebral Edema in Children With Diabetic Ketoacidosis Randomized to 2 Different Rehydration Protocols". Pediatrics. 131 (1): e73–e80. doi:10.1542/peds.2012-1049. ISSN 0031-4005. PMC 3529948. PMID 23230065. {{cite journal}}: Check date values in: |date= (help)
  21. ^ Myers, Sage R.; Glaser, Nicole S.; Trainor, Jennifer L.; Nigrovic, Lise E.; Garro, Aris; Tzimenatos, Leah; Quayle, Kimberly S.; Kwok, Maria Y.; Rewers, Arleta; Stoner, Michael J.; Schunk, Jeff E.; McManemy, Julie K.; Brown, Kathleen M.; DePiero, Andrew D.; Olsen, Cody S. (2020-12-04). "Frequency and Risk Factors of Acute Kidney Injury During Diabetic Ketoacidosis in Children and Association With Neurocognitive Outcomes". JAMA Network Open. 3 (12): e2025481. doi:10.1001/jamanetworkopen.2020.25481. ISSN 2574-3805.
  22. ^ Kuppermann, Nathan; Ghetti, Simona; Schunk, Jeff E.; Stoner, Michael J.; Rewers, Arleta; McManemy, Julie K.; Myers, Sage R.; Nigrovic, Lise E.; Garro, Aris; Brown, Kathleen M.; Quayle, Kimberly S.; Trainor, Jennifer L.; Tzimenatos, Leah; Bennett, Jonathan E.; DePiero, Andrew D. (2018-06-14). "Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis". The New England journal of medicine. 378 (24): 2275–2287. doi:10.1056/NEJMoa1716816. ISSN 0028-4793. PMC 6051773. PMID 29897851.
  23. ^ Kuppermann, Nathan; Dayan, Peter S.; Levine, Deborah A.; Vitale, Melissa; Tzimenatos, Leah; Tunik, Michael G.; Saunders, Mary; Ruddy, Richard M.; Roosevelt, Genie; Rogers, Alexander J.; Powell, Elizabeth C.; Nigrovic, Lise E.; Muenzer, Jared; Linakis, James G.; Grisanti, Kathleen (2019-4). "A Clinical Prediction Rule to Identify Febrile Infants 60 Days and Younger at Low Risk for Serious Bacterial Infections". JAMA Pediatrics. 173 (4): 342–351. doi:10.1001/jamapediatrics.2018.5501. ISSN 2168-6203. PMC 6450281. PMID 30776077. {{cite journal}}: Check date values in: |date= (help)
  24. ^ "Imaging Initiative" (PDF).{{cite web}}: CS1 maint: url-status (link)
  25. ^ Osmond, Martin H.; Klassen, Terry P.; Wells, George A.; Davidson, Jennifer; Correll, Rhonda; Boutis, Kathy; Joubert, Gary; Gouin, Serge; Khangura, Simi; Turner, Troy; Belanger, Francois (2018-07-09). "Validation and refinement of a clinical decision rule for the use of computed tomography in children with minor head injury in the emergency department". CMAJ. 190 (27): E816–E822. doi:10.1503/cmaj.170406. ISSN 0820-3946. PMC 6041249. PMID 29986857.
  26. ^ Tzimenatos, Leah; Kim, Emily; Kuppermann, Nathan (2015-01). "The Pediatric Emergency Care Applied Research Network". Pediatric Emergency Care. 31 (1): 70–76. doi:10.1097/pec.0000000000000303. ISSN 0749-5161. {{cite journal}}: Check date values in: |date= (help)
  27. ^ "The Pediatric Emergency Care Applied Research Network (PECARN): Rationale, Development, and First Steps*". Academic Emergency Medicine. 10 (6): 661–668. 2008-06-28. doi:10.1111/j.1553-2712.2003.tb00053.x. ISSN 1069-6563.
  28. ^ "2022 Award Recipients – Society for Pediatric Research". Retrieved 2023-05-10.
  29. ^ "Tupper Prize and Williams Award honor faculty for achievement". UC Davis Health News. Retrieved 2023-05-10.
  30. ^ "School of Medicine's Kuppermann, Fancher, Godzich garner awards from Academic Senate, Academic Federation". UC Davis Health News. Retrieved 2023-05-10.
  31. ^ O'Donnell, Thomas (2019-08-16). "Chancellor's Achievement Awards for Diversity and Community". Diversity, Equity & Inclusion. Retrieved 2023-05-10.
  32. ^ "Faculty Development l Deans' Team Award for Excellence List of Recipients". health.ucdavis.edu. Retrieved 2023-05-10.
  33. ^ https://health.ucdavis.edu/medschool/somsenate/pdf/school-of-medicine-research-award-2023.pdf
  34. ^ "Emergency Physician Nathan Kuppermann, MD, MPH, Wins Award for Significant Contributions to Pediatric Emergency Medicine - News | EBSCO". www.ebsco.com. Retrieved 2023-05-10.
  35. ^ "Faculty Development - Deans' Award for Excellence in Mentoring List". health.ucdavis.edu. Retrieved 2023-05-10.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Nathan_Kuppermann&oldid=1155669961"