Collecting duct carcinoma: Difference between revisions

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'''Bellini duct carcinoma''' (BDC) is a rare type of kidney cancer that progresses and spreads very quickly. BDC starts in the [[Duct of Bellini|Bellini]] duct of the kidney. BDC was only discovered recently because of advances in technology; until recently, it was commonly thought of as [[renal cell carcinoma]]. BDC is extremely rare, with only ten reported cases as of Feb. 1991, and it accounts for 0.4% to 2.6% of all [[renal]] [[neoplasms]].
'''Bellini duct carcinoma''' ('''BDC''', also known as '''low-grade collecting duct carcinoma'''<ref name="pmid19011562"/> and '''tubulocystic carcinoma'''<ref name="pmid19011562"/>) is a type of [[kidney cancer]] that originates in the [[duct of Bellini]] of the kidney. It is rare, accounting for 1-3% of all kidney cancers.<ref name="pmid15986594">{{cite journal
| author = Fakhrai N, Haitel A, Balassy C, Zielinski CC, Schmidinger M
| title = Major response and clinical benefit following third-line treatment for Bellini duct carcinoma
| journal = Wien. Klin. Wochenschr.
| volume = 117
| issue = 1-2
| pages = 63–5
| year = 2005
| month = January
| pmid = 15986594
| doi =
| url =
| issn =
}}</ref> BDC progresses and spreads very quickly. Previously, BDC was commonly diagnosed as [[renal cell carcinoma]]. However, BDC does not respond well to [[chemotherapy]] drugs used for renal cell carcinoma. BDC may be related to [[urothelial carcinoma]].



==Discovery==
==Discovery==
Line 7: Line 21:
==Study==
==Study==
BDC is extremely rare, and thus hard to study. In a well documented case, a 56 year old man was found to have BDC. In November 1994, he was brought in to the clinical study for an examination of his left [[Renal_tubule#Renal_tubule|renal mass]]. The patient was not suffering from flank pain or gross [[hematuria]], common symptoms of [[urology|urological disease]]. Through testing the patients disease was classified, and then underwent transperitoneal radical nephrectomy. His kidney was found to have a 43 mm (1.62 inches) tumor.<ref name="jjco" /> Currently, very few published works compare histopathological and clinical data. Because of this, there is no standard protocol for diagnosis and treatment for the renal neoplasm.<ref>Maestroni, Umberto . "A RENAL CANCER WITH INTERMEDIATE CHARACTERISTICS BETWEEN RENAL CANCER WITH INTERMEDIATE CHARACTERISTICS BETWEEN." Urology Operative Unit, Hospital and University of Parma, Parma, Italy 94(2006):</ref>
BDC is extremely rare, and thus hard to study. In a well documented case, a 56 year old man was found to have BDC. In November 1994, he was brought in to the clinical study for an examination of his left [[Renal_tubule#Renal_tubule|renal mass]]. The patient was not suffering from flank pain or gross [[hematuria]], common symptoms of [[urology|urological disease]]. Through testing the patients disease was classified, and then underwent transperitoneal radical nephrectomy. His kidney was found to have a 43 mm (1.62 inches) tumor.<ref name="jjco" /> Currently, very few published works compare histopathological and clinical data. Because of this, there is no standard protocol for diagnosis and treatment for the renal neoplasm.<ref>Maestroni, Umberto . "A RENAL CANCER WITH INTERMEDIATE CHARACTERISTICS BETWEEN RENAL CANCER WITH INTERMEDIATE CHARACTERISTICS BETWEEN." Urology Operative Unit, Hospital and University of Parma, Parma, Italy 94(2006):</ref>

==Histology==
This cancer has a distinctive "bubble wrap" appearance.<ref name="pmid19011562">{{cite journal
| author = Amin MB, MacLennan GT, Gupta R, Grignon D, Paraf F, Vieillefond A, Paner GP, Stovsky M, Young AN, Srigley JR, Cheville JC
| title = Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma
| journal = Am. J. Surg. Pathol.
| volume = 33
| issue = 3
| pages = 384–92
| year = 2009
| month = March
| pmid = 19011562
| doi = 10.1097/PAS.0b013e3181872d3f
| url =
| issn =
}}</ref> It has been reported to occur together with urothelial carcinoma of the bladder,<ref name="pmid18364277">{{cite journal
| author = Hsiao HL, Yeh HC, Chang TH, Ke HL, Lin HC, Wu WJ, Huang CH, Lee YC
| title = Renal collecting duct carcinoma and concomitant bladder urothelial carcinoma: a case report
| journal = Kaohsiung J. Med. Sci.
| volume = 24
| issue = 3
| pages = 157–62
| year = 2008
| month = March
| pmid = 18364277
| doi =
| url = http://ajws.elsevier.com/ajws_pubmed/pubmed_switch.asp?journal_issn=1607-551X&art_pub_year=2008&%20art_pub_month=03&art_pub_vol=24&art_sp=157
| issn =
}}</ref><ref name="pmid19048932">{{cite journal
| author = Okuda H, Tei N, Shimizu K, Imazu T, Yoshimura K, Kiyohara H, Nakamura Y, Fujimura H
| title = [Case report: collecting (Bellini) duct carcinoma during the follow-up for bladder cancer]
| language = Japanese
| journal = Hinyokika Kiyo
| volume = 54
| issue = 10
| pages = 665–8
| year = 2008
| month = October
| pmid = 19048932
| doi =
| url =
| issn =
}}</ref> and a cancer with intermediate histology also has been reported,<ref name="pmid17260499">{{cite journal
| author = Maestroni U, Ferretti S, Dinale F, Froio E, Pilato FP, Ciuffreda M, Mellissari M, Cortellini P
| title = A renal cancer with intermediate characteristics between collecting (Bellini) duct carcinoma and urothelial carcinoma: case report and review of the literature
| journal = Tumori
| volume = 92
| issue = 6
| pages = 545–8
| year = 2006
| pmid = 17260499
| doi =
| url =
| issn =
}}</ref> leading to the suspicion that these cancers are related.<ref name="pmid19048932"/>


==Symptoms==
==Symptoms==
Line 22: Line 91:
<references/>
<references/>


[[Category:Types of cancer]]
[[Category:Rare cancers]]
{{oncology-stub}}
{{oncology-stub}}

Revision as of 22:59, 3 March 2009

You must add a |reason= parameter to this Cleanup template – replace it with {{Cleanup|reason=<Fill reason here>}}, or remove the Cleanup template.
 Bellini duct carcinoma (BDC, also known as low-grade collecting duct carcinoma[1] and tubulocystic carcinoma[1]) is a type of kidney cancer that originates in the duct of Bellini of the kidney. It is rare, accounting for 1-3% of all kidney cancers.[2] BDC progresses and spreads very quickly. Previously, BDC was commonly diagnosed as renal cell carcinoma. However, BDC does not respond well to chemotherapy drugs used for renal cell carcinoma. BDC may be related to urothelial carcinoma.


Discovery

BDC was thought to be renal cell carcinoma, until "recently developed techniques of lectin histochemistry" helped forward knowledge of kidney duct cancers.[3]

Study

BDC is extremely rare, and thus hard to study. In a well documented case, a 56 year old man was found to have BDC. In November 1994, he was brought in to the clinical study for an examination of his left renal mass. The patient was not suffering from flank pain or gross hematuria, common symptoms of urological disease. Through testing the patients disease was classified, and then underwent transperitoneal radical nephrectomy. His kidney was found to have a 43 mm (1.62 inches) tumor.[3] Currently, very few published works compare histopathological and clinical data. Because of this, there is no standard protocol for diagnosis and treatment for the renal neoplasm.[4]

Histology

This cancer has a distinctive "bubble wrap" appearance.[1] It has been reported to occur together with urothelial carcinoma of the bladder,[5][6] and a cancer with intermediate histology also has been reported,[7] leading to the suspicion that these cancers are related.[6]

Symptoms

In a case with a 53 year old woman, the patient suffered from irregular fever, decreased weight loss and one episode of haematuria.[8] In her case, she suffered from the those symptoms, because the medication she was taking had no effect. In an extreme case, the patient died of BDC, after it metastasized in his lungs.[9]

Importance

In the conclusion of the case study mentioned above, the Nara Medical University of Japan, had this to say about BDC:

In conclusion, BDC is a rare tumor with a clinically rapid and progressively malignant course. This makes it important to determine the origin of all renal tumors and to distinguish rare forms such as BDC from common types of renal cell carcinoma. Moreover, it is highly desirable that a modality of treatment be established for this malignancy.[3]


Notes

  1. ^ a b c Amin MB, MacLennan GT, Gupta R, Grignon D, Paraf F, Vieillefond A, Paner GP, Stovsky M, Young AN, Srigley JR, Cheville JC (2009). "Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma". Am. J. Surg. Pathol. 33 (3): 384–92. doi:10.1097/PAS.0b013e3181872d3f. PMID 19011562. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  2. ^ Fakhrai N, Haitel A, Balassy C, Zielinski CC, Schmidinger M (2005). "Major response and clinical benefit following third-line treatment for Bellini duct carcinoma". Wien. Klin. Wochenschr. 117 (1–2): 63–5. PMID 15986594. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ a b c O Natsume, S Ozono, T Futami, and M Ohta (1997). "Bellini duct carcinoma: a case report". Japanese Journal of Clinical Oncology. 27 (2): 107–110. doi:10.1093/jjco/27.2.107. Retrieved 2008-06-03. {{cite journal}}: Unknown parameter |quotes= ignored (help)CS1 maint: multiple names: authors list (link)
  4. ^ Maestroni, Umberto . "A RENAL CANCER WITH INTERMEDIATE CHARACTERISTICS BETWEEN RENAL CANCER WITH INTERMEDIATE CHARACTERISTICS BETWEEN." Urology Operative Unit, Hospital and University of Parma, Parma, Italy 94(2006):
  5. ^ Hsiao HL, Yeh HC, Chang TH, Ke HL, Lin HC, Wu WJ, Huang CH, Lee YC (2008). "Renal collecting duct carcinoma and concomitant bladder urothelial carcinoma: a case report". Kaohsiung J. Med. Sci. 24 (3): 157–62. PMID 18364277. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  6. ^ a b Okuda H, Tei N, Shimizu K, Imazu T, Yoshimura K, Kiyohara H, Nakamura Y, Fujimura H (2008). "[Case report: collecting (Bellini) duct carcinoma during the follow-up for bladder cancer]". Hinyokika Kiyo (in Japanese). 54 (10): 665–8. PMID 19048932. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  7. ^ Maestroni U, Ferretti S, Dinale F, Froio E, Pilato FP, Ciuffreda M, Mellissari M, Cortellini P (2006). "A renal cancer with intermediate characteristics between collecting (Bellini) duct carcinoma and urothelial carcinoma: case report and review of the literature". Tumori. 92 (6): 545–8. PMID 17260499.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. ^ K Pavithran, D Hazarika, D C Doval, R Kumar (2006). "Bellini Duct carcinoma - A Case Report" (PDF). Indian Journal of Medical & Paediatric Oncology. 27 (1): 38–41. Retrieved 2008-06-03. {{cite journal}}: Unknown parameter |quotes= ignored (help)CS1 maint: multiple names: authors list (link)
  9. ^ Kruπlin , Boæo . "COLLECTING DUCT CARCINOMA OF THE KIDNEY." Departments of Pathology and of Urology, Sestre Milosrdnice University Hospital, Zagreb, Croatia 40(2001): 21-25.
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