Hemangioblast: Difference between revisions
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'''Hemangioblast''' is a [[multipotent]] cell, common precursor to [[hematopoietic]] and [[endothelial]] cells. Hemangioblast was first hypothesized in 1900 by [[Wilhelm His, Jr.|W. His]]. |
'''Hemangioblast''' is a [[multipotent]] cell, common precursor to [[hematopoietic]] and [[endothelial]] cells.<ref name="pmid19386101">{{cite journal |author=Basak GW, Yasukawa S, Alfaro A, ''et al.'' |title=Human embryonic stem cells hemangioblast express HLA-antigens |journal=J Transl Med |volume=7 |issue= |pages=27 |year=2009 |pmid=19386101 |pmc=2680830 |doi=10.1186/1479-5876-7-27 |url=http://www.translational-medicine.com/content/7//27}}</ref> Hemangioblast was first hypothesized in 1900 by [[Wilhelm His, Jr.|W. His]]. |
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Hemangioblasts have been first extracted from [[embryo]]nic cultures and manipulated by [[cytokines]] to differentiate along either hematopoietic or endothelial route. It has been shown that these pre-endothelial/pre-hematopoietic cells in the [[embryo]] arise out of a phenotype [[CD34]] population. It was then found that hemangioblasts are also present in the tissue of fully developed individuals, such as in newborn [[infants]] and adults. |
Hemangioblasts have been first extracted from [[embryo]]nic cultures and manipulated by [[cytokines]] to differentiate along either hematopoietic or endothelial route. It has been shown that these pre-endothelial/pre-hematopoietic cells in the [[embryo]] arise out of a phenotype [[CD34]] population. It was then found that hemangioblasts are also present in the tissue of fully developed individuals, such as in newborn [[infants]] and adults. |
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==References== |
==References== |
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{{Human cell types derived primarily from mesoderm}} |
{{Human cell types derived primarily from mesoderm}} |
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Revision as of 17:38, 18 April 2010
Hemangioblast is a multipotent cell, common precursor to hematopoietic and endothelial cells.[1] Hemangioblast was first hypothesized in 1900 by W. His.
Hemangioblasts have been first extracted from embryonic cultures and manipulated by cytokines to differentiate along either hematopoietic or endothelial route. It has been shown that these pre-endothelial/pre-hematopoietic cells in the embryo arise out of a phenotype CD34 population. It was then found that hemangioblasts are also present in the tissue of fully developed individuals, such as in newborn infants and adults.
Adult Hemangioblast
There is now emerging evidence of hemangioblasts that continue to exist in the adult as circulating stem cells in the peripheral blood that can give rise to both endothelial cells and hematopoietic cells. These cells are thought to express both CD34 and CD133 [2] These cells are likely derived from the bone marrow, and may even be derived from hematopoietic stem cells.
See also
External links
References
- ^ Basak GW, Yasukawa S, Alfaro A; et al. (2009). "Human embryonic stem cells hemangioblast express HLA-antigens". J Transl Med. 7: 27. doi:10.1186/1479-5876-7-27. PMC 2680830. PMID 19386101.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Loges S; et al. (2004). "Identification of the Adult Hemangioblast". Stem Cells and Development. 13 (1): 229–42. doi:10.1089/154732804323099163. PMID 15186719.
{{cite journal}}: Explicit use of et al. in:|author=(help)