DLX6-AS1: Difference between revisions

Add links
From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
m moved extra refs to FR sec
m HC info
Line 1: Line 1:
{{Infobox rfam
{{Infobox rfam
| Name = Evf2
| Name = Evf-2
| image = Evf2-ss-cons.png
| image = Evf2-ss-cons.png
| width =
| width =
| caption = Conserved secondary structure of Evf2 RNA.
| caption = Conserved secondary structure of Evf2 RNA.
| Symbol = Evf2
| Symbol = Evf-2
| AltSymbols =
| AltSymbols =
| Rfam =
| Rfam =
| RNA_type = Gene;
| RNA_type = RNA gene
| Tax_domain = [[Mammalia]]
| Tax_domain = [[Mammalia]]
| CAS_number =
| CAS_number =
Line 21: Line 21:
}}
}}


'''Evf2''' is a [[long noncoding RNA|long polyadenylated ncRNA]] (lpncRNA) which regulates [[gene expression]] in a region of the brain which produces GABAergic [[interneurons]] during development.<ref>{{cite web| url=http://www.sciencedaily.com/releases/2009/08/090821163525.htm|title=Non-Coding RNA Called Evf2 Is Important For Gene Regulation|date=Sep 1 2009|author=Sciencedaily|accessdate=26th July 2010}}</ref> It is involved in the [[sonic hedgehog]] signalling pathway and works alongside DLX [[homeodomain|homeodomain proteins]] to increase the effectiveness of the [[Dlx|Dlx5/6]] enhancer element within neural [[stem cell|stem cells]].<ref name="Bon09">{{cite journal |author=Bond AM, Vangompel MJ, Sametsky EA, ''et al.'' |title=Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry |journal=Nat. Neurosci. |volume=12 |issue=8 |pages=1020–7 |year=2009 |month=August |pmid=19620975 |doi=10.1038/nn.2371 |url=http://dx.doi.org/10.1038/nn.2371 |accessdate=2010-07-26}}</ref>
'''Evf-2''' (Embryonic ventral forebrain-2)<ref>{{cite journal |author=Kohtz JD, Fishell G |title=Developmental regulation of EVF-1, a novel non-coding RNA transcribed upstream of the mouse Dlx6 gene |journal=Gene Expr. Patterns |volume=4 |issue=4 |pages=407–12 |year=2004 |month=July |pmid=15183307 |doi=10.1016/j.modgep.2004.01.007 |url=http://linkinghub.elsevier.com/retrieve/pii/S1567133X04000080 |accessdate=2010-07-27}}</ref> is a [[long noncoding RNA|long polyadenylated ncRNA]] (lpncRNA) which regulates [[gene expression]] in a region of the brain which produces GABAergic [[interneurons]] during development.<ref>{{cite web| url=http://www.sciencedaily.com/releases/2009/08/090821163525.htm|title=Non-Coding RNA Called Evf2 Is Important For Gene Regulation|date=Sep 1 2009|author=Sciencedaily|accessdate=26th July 2010}}</ref> It is involved in the [[sonic hedgehog]] (shh) signalling pathway and works in conjunction with DLX [[homeodomain|homeodomain proteins]] to increase the effectiveness of the [[Dlx|Dlx5/6]] enhancer element within neural [[stem cell|stem cells]]. The interneurones are found in the [[hippocampus]] of the adult brain, an area responsible for [[learning]] and [[memory]].<ref name="Bon09">{{cite journal |author=Bond AM, Vangompel MJ, Sametsky EA, ''et al.'' |title=Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry |journal=Nat. Neurosci. |volume=12 |issue=8 |pages=1020–7 |year=2009 |month=August |pmid=19620975 |doi=10.1038/nn.2371 |url=http://dx.doi.org/10.1038/nn.2371 |accessdate=2010-07-26}}</ref>

⚫
GABAergic interneurons have been implicated in a number of [[psychiatric disorders]] including [[autism]]<ref>{{cite journal |author=Dani VS, Chang Q, Maffei A, Turrigiano GG, Jaenisch R, Nelson SB |title=Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue=35 |pages=12560–5 |year=2005 |month=August |pmid=16116096 |pmc=1194957 |doi=10.1073/pnas.0506071102 |url=http://www.pnas.org/cgi/pmidlookup?view=long&pmid=16116096 |accessdate=2010-07-26}}</reF>, [[schizophrenia]]<ref>{{cite journal |author=Lewis DA, Hashimoto T, Volk DW |title=Cortical inhibitory neurons and schizophrenia |journal=Nat. Rev. Neurosci. |volume=6 |issue=4 |pages=312–24 |year=2005 |month=April |pmid=15803162 |doi=10.1038/nrn1648 |url=http://dx.doi.org/10.1038/nrn1648 |accessdate=2010-07-26}}</ref> and [[epilepsy]];<ref>{{cite journal |author=Di Cristo G |title=Development of cortical GABAergic circuits and its implications for neurodevelopmental disorders |journal=Clin. Genet. |volume=72 |issue=1 |pages=1–8 |year=2007 |month=July |pmid=17594392 |doi=10.1111/j.1399-0004.2007.00822.x |url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0009-9163&date=2007&volume=72&issue=1&spage=1 |accessdate=2010-07-26}}</ref> as Evf2 controls the development of these neurones, it has been subject to studies regarding the causation of these disorders.<ref name="Bon09" />

⚫
Evf2 is the first known long non-coding RNA to be involved in [[organogenesis]].<ref>{{cite journal |author=Shamovsky I, Nudler E |title=Gene control by large noncoding RNAs |journal=Sci. STKE |volume=2006 |issue=355 |pages=pe40 |year=2006 |month=October |pmid=17018852 |doi=10.1126/stke.3552006pe40 |url=http://stke.sciencemag.org/cgi/pmidlookup?view=long&pmid=17018852 |accessdate=2010-07-26}}</ref>


⚫
GABAergic interneurons have been implicated in a number of [[psychiatric disorders]] including [[autism]],<ref>{{cite journal |author=Dani VS, Chang Q, Maffei A, Turrigiano GG, Jaenisch R, Nelson SB |title=Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue=35 |pages=12560–5 |year=2005 |month=August |pmid=16116096 |pmc=1194957 |doi=10.1073/pnas.0506071102 |url=http://www.pnas.org/cgi/pmidlookup?view=long&pmid=16116096 |accessdate=2010-07-26}}</ref> [[schizophrenia]]<ref>{{cite journal |author=Lewis DA, Hashimoto T, Volk DW |title=Cortical inhibitory neurons and schizophrenia |journal=Nat. Rev. Neurosci. |volume=6 |issue=4 |pages=312–24 |year=2005 |month=April |pmid=15803162 |doi=10.1038/nrn1648 |url=http://dx.doi.org/10.1038/nrn1648 |accessdate=2010-07-26}}</ref> and [[epilepsy]];<ref>{{cite journal |author=Di Cristo G |title=Development of cortical GABAergic circuits and its implications for neurodevelopmental disorders |journal=Clin. Genet. |volume=72 |issue=1 |pages=1–8 |year=2007 |month=July |pmid=17594392 |doi=10.1111/j.1399-0004.2007.00822.x |url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0009-9163&date=2007&volume=72&issue=1&spage=1 |accessdate=2010-07-26}}</ref> as Evf2 controls the development of these neurones, it has been subject to studies regarding the causation of these disorders.<ref name="Bon09" />


Evf2 is an [[alternative splicing|splice variant]] of [[Evf1]], another developmentally regulated ncRNA targetted by shh signalling.<ref>{{cite journal |author=Feng J, Bi C, Clark BS, Mady R, Shah P, Kohtz JD |title=The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator |journal=Genes Dev. |volume=20 |issue=11 |pages=1470–84 |year=2006 |month=June |pmid=16705037 |pmc=1475760 |doi=10.1101/gad.1416106 |url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=16705037 |accessdate=2010-07-27}}</ref> Evf2 is the first known long non-coding RNA to be involved in [[organogenesis]].<ref>{{cite journal |author=Shamovsky I, Nudler E |title=Gene control by large noncoding RNAs |journal=Sci. STKE |volume=2006 |issue=355 |pages=pe40 |year=2006 |month=October |pmid=17018852 |doi=10.1126/stke.3552006pe40 |url=http://stke.sciencemag.org/cgi/pmidlookup?view=long&pmid=17018852 |accessdate=2010-07-26}}</ref>


==See also==
==See also==
*[[Long noncoding RNA]]
*[[Long noncoding RNA]]
*[[Dlx (gene)]]
*[[Gamma-Aminobutyric acid]]
*[[Gamma-Aminobutyric acid]]
*[[Chemoaffinity hypothesis]]


==References==
==References==
Line 39: Line 39:
{{refbegin}}
{{refbegin}}
*{{cite journal |author=Kohtz JD, Baker DP, Corte G, Fishell G |title=Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog |journal=Development |volume=125 |issue=24 |pages=5079–89 |year=1998 |month=December |pmid=9811591 |doi= |url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=9811591 |accessdate=2010-07-26}}
*{{cite journal |author=Kohtz JD, Baker DP, Corte G, Fishell G |title=Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog |journal=Development |volume=125 |issue=24 |pages=5079–89 |year=1998 |month=December |pmid=9811591 |doi= |url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=9811591 |accessdate=2010-07-26}}
⚫
*{{cite journal |author=Ingham PW, McMahon AP |title=Hedgehog signaling in animal development: paradigms and principles |journal=Genes Dev. |volume=15 |issue=23 |pages=3059–87 |year=2001 |month=December |pmid=11731473 |doi=10.1101/gad.938601 |url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=11731473 |accessdate=2010-07-27}}
*{{cite journal |author=Licastro D, Gennarino VA, Petrera F, Sanges R, Banfi S, Stupka E |title=Promiscuity of enhancer, coding and non-coding transcription functions in ultraconserved elements |journal=BMC Genomics |volume=11 |issue= |pages=151 |year=2010 |pmid=20202189 |pmc=2847969 |doi=10.1186/1471-2164-11-151 |url=http://www.biomedcentral.com/1471-2164/11/151 |accessdate=2010-07-26}}
*{{cite journal |author=Licastro D, Gennarino VA, Petrera F, Sanges R, Banfi S, Stupka E |title=Promiscuity of enhancer, coding and non-coding transcription functions in ultraconserved elements |journal=BMC Genomics |volume=11 |issue= |pages=151 |year=2010 |pmid=20202189 |pmc=2847969 |doi=10.1186/1471-2164-11-151 |url=http://www.biomedcentral.com/1471-2164/11/151 |accessdate=2010-07-26}}
*{{cite journal |author=Erdmann VA, Barciszewska MZ, Hochberg A, de Groot N, Barciszewski J |title=Regulatory RNAs |journal=Cell. Mol. Life Sci. |volume=58 |issue=7 |pages=960–77 |year=2001 |month=June |pmid=11497242 |doi= |url=http://link.springer.de/link/service/journals/00018/bibs/1058007/10580960.htm |accessdate=2010-07-27}}
{{refend}}
{{refend}}

Revision as of 10:38, 27 July 2010

Evf-2
Conserved secondary structure of Evf2 RNA.
Identifiers
SymbolEvf-2
Other data
RNA typeRNA gene
Domain(s)Mammalia
PDB structuresPDBe

Evf-2 (Embryonic ventral forebrain-2)[1] is a long polyadenylated ncRNA (lpncRNA) which regulates gene expression in a region of the brain which produces GABAergic interneurons during development.[2] It is involved in the sonic hedgehog (shh) signalling pathway and works in conjunction with DLX homeodomain proteins to increase the effectiveness of the Dlx5/6 enhancer element within neural stem cells. The interneurones are found in the hippocampus of the adult brain, an area responsible for learning and memory.[3]

GABAergic interneurons have been implicated in a number of psychiatric disorders including autism,[4] schizophrenia[5] and epilepsy;[6] as Evf2 controls the development of these neurones, it has been subject to studies regarding the causation of these disorders.[3]

Evf2 is an splice variant of Evf1, another developmentally regulated ncRNA targetted by shh signalling.[7] Evf2 is the first known long non-coding RNA to be involved in organogenesis.[8]

See also

References

  1. ^ Kohtz JD, Fishell G (2004). "Developmental regulation of EVF-1, a novel non-coding RNA transcribed upstream of the mouse Dlx6 gene". Gene Expr. Patterns. 4 (4): 407–12. doi:10.1016/j.modgep.2004.01.007. PMID 15183307. Retrieved 2010-07-27. {{cite journal}}: Unknown parameter |month= ignored (help)
  2. ^ Sciencedaily (Sep 1 2009). "Non-Coding RNA Called Evf2 Is Important For Gene Regulation". Retrieved 26th July 2010. {{cite web}}: Check date values in: |accessdate= and |date= (help)
  3. ^ a b Bond AM, Vangompel MJ, Sametsky EA; et al. (2009). "Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry". Nat. Neurosci. 12 (8): 1020–7. doi:10.1038/nn.2371. PMID 19620975. Retrieved 2010-07-26. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  4. ^ Dani VS, Chang Q, Maffei A, Turrigiano GG, Jaenisch R, Nelson SB (2005). "Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome". Proc. Natl. Acad. Sci. U.S.A. 102 (35): 12560–5. doi:10.1073/pnas.0506071102. PMC 1194957. PMID 16116096. Retrieved 2010-07-26. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  5. ^ Lewis DA, Hashimoto T, Volk DW (2005). "Cortical inhibitory neurons and schizophrenia". Nat. Rev. Neurosci. 6 (4): 312–24. doi:10.1038/nrn1648. PMID 15803162. Retrieved 2010-07-26. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  6. ^ Di Cristo G (2007). "Development of cortical GABAergic circuits and its implications for neurodevelopmental disorders". Clin. Genet. 72 (1): 1–8. doi:10.1111/j.1399-0004.2007.00822.x. PMID 17594392. Retrieved 2010-07-26. {{cite journal}}: Unknown parameter |month= ignored (help)
  7. ^ Feng J, Bi C, Clark BS, Mady R, Shah P, Kohtz JD (2006). "The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator". Genes Dev. 20 (11): 1470–84. doi:10.1101/gad.1416106. PMC 1475760. PMID 16705037. Retrieved 2010-07-27. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  8. ^ Shamovsky I, Nudler E (2006). "Gene control by large noncoding RNAs". Sci. STKE. 2006 (355): pe40. doi:10.1126/stke.3552006pe40. PMID 17018852. Retrieved 2010-07-26. {{cite journal}}: Unknown parameter |month= ignored (help)

Further reading

Retrieved from "https://en.wikipedia.org/w/index.php?title=DLX6-AS1&oldid=375709852"