Sebaceous adenitis: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
Keetanii (talk | contribs)
770 edits
Picture caption + External link + Access dates
reformatted refs
Line 1: Line 1:
{{Expert-subject|date=April 2011}}
{{Expert-subject|date=April 2011}}


In canines, '''sebaceous adenitis''', or '''SA''', refers to the [[autoimmune disease]] found in some breeds of dog. It is an uncommon, [[idiopathic]] skin disease,<ref name=Craig>{{cite journal |last=Craig |first=Mark |journal=Companion Animal |year=2006 |month=June |volume=11 |issue=5 |doi=10.1111/j.2044-3862.2006.tb00066.x |url=http://onlinelibrary.wiley.com/doi/10.1111/j.2044-3862.2006.tb00066.x/abstract |accessdate=7 April 2011}}</ref> characterised by an immune response against the dog's [[sebaceous glands]] (glands found in the [[hair follicles]] in the skin [[dermis]]), which can lead to the destruction of the gland. It was first described in veterinary literature in the 1980s.<ref name=Spaterna>{{cite journal |last=Spaterna |first=A |coauthors=M.T. Antognoni, S. Cappuccini and B. Tesei |title=Sebaceous Adenitis in the Dog: Three Cases |journal=Veterinary Research Communications |year=2003 |volume=27 |issue=Supplement 1 |pages=441-443 |doi=10.1023/B:VERC.0000014199.39879.bb |url=Sebaceous Adenitis in the Dog: Three Cases |accessdate=7 April 2011}}</ref>
In canines, '''sebaceous adenitis''', or '''SA''', refers to the [[autoimmune disease]] found in some breeds of dog. It is an uncommon, [[idiopathic]] skin disease,<ref name=Craig>{{cite journal |pages=62–8 |doi=10.1111/j.2044-3862.2006.tb00066.x}}</ref> characterised by an immune response against the dog's [[sebaceous glands]] (glands found in the [[hair follicles]] in the skin [[dermis]]), which can lead to the destruction of the gland. It was first described in veterinary literature in the 1980s.<ref name=Spaterna>{{cite journal |pages=441-443 |doi=10.1023/B:VERC.0000014199.39879.bb}}</ref>
[[File:Skin.jpg|thumb|Anatomy of human skin which shows the location of human and canine sebaceous glands]]
[[File:Skin.jpg|thumb|Anatomy of human skin which shows the location of human and canine sebaceous glands]]


Line 16: Line 16:
* Standard [[Poodle]]<ref name="Pfeiffer"/>
* Standard [[Poodle]]<ref name="Pfeiffer"/>
* [[Viszla]]<ref name="Pfeiffer"/>
* [[Viszla]]<ref name="Pfeiffer"/>
*[[Springer Spaniel]]<ref name=Hernblad>{{cite journal |pmid=18501018}}</ref>
*[[Springer Spaniel]]<ref name=Hernblad>{{cite journal |last=Hernblad |first=Tevell E |coauthors=Bergvall K, Egenvall A. |title=Sebaceous adenitis in Swedish dogs, a retrospective study of 104 cases. |journal=Acta Veterinaria Scandinavia |date=25 |year=2008 |month=May |volume=50 |issue=11 |url=http://www.ncbi.nlm.nih.gov/pubmed/18501018 |accessdate=7 April 2011}}</ref>


Breeds also mentioned in scientific literature as having some susceptability include:
Breeds also mentioned in scientific literature as having some susceptability include:
* [[German Shepherd Dog]]<ref name=Gross>{{cite book |last=Gross |first=Thelma Lee |title=Skin diseases of the dog and cat: clinical and histopathologic diagnosis |year=2005 |publisher=Wiley-Blackwell |isbn=9780632064526 |edition=second |coauthors=Peter J. Ihrke, Emily J. Walder, Verena K. Affolter}}</ref>
* [[German Shepherd Dog]]<ref name=Gross>{{cite book |last=Gross |first=Thelma Lee |title=Skin diseases of the dog and cat: clinical and histopathologic diagnosis |year=2005 |publisher=Wiley-Blackwell |isbn=9780632064526 |edition=second |coauthors=Peter J. Ihrke, Emily J. Walder, Verena K. Affolter}}{{pn}}</ref>
* [[Dachshund]]<ref name="Craig"/>
* [[Dachshund]]<ref name="Craig"/>
* [[Old English Sheepdog]]<ref name="Gross"/>
* [[Old English Sheepdog]]<ref name="Gross"/>
Line 30: Line 30:
* [[Mixed-breed dog|Mixed-breeds]]<ref name=Linek>{{cite journal|last=Linek|first=Monika|title=Sebaceous adenitis in the dog|journal=Veterinary Focus|year=2008|volume=18|issue=1|pages=12-16|url=http://www.edliny.com/Encyclopedy/Veterinary%20Focus/181/2.pdf|accessdate=10 April 2011}}</ref>
* [[Mixed-breed dog|Mixed-breeds]]<ref name=Linek>{{cite journal|last=Linek|first=Monika|title=Sebaceous adenitis in the dog|journal=Veterinary Focus|year=2008|volume=18|issue=1|pages=12-16|url=http://www.edliny.com/Encyclopedy/Veterinary%20Focus/181/2.pdf|accessdate=10 April 2011}}</ref>


There has also been mention of the condition in cats, rabbits<ref name="Linek"/> and horses.<ref name=Osborne>{{cite journal|last=Osborne|first=Christina|title=Sebaceous adenitis in a 7-year-old Arabian gelding|journal=The Canadian Veterinary Journal|year=2006|month=June|volume=47|issue=6|pages=583–586|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1461412/|accessdate=10 April 2011}}</ref>
There has also been mention of the condition in cats, rabbits<ref name="Linek"/> and horses.<ref name=Osborne>{{cite journal |last=Osborne |first=Christina |pmid=16808233}}</ref>


==Diagnosis==
==Diagnosis==
Line 47: Line 47:
* http://www.upei.ca/~cidd/Diseases/dermatology/sebaceous%20adenitis.htm General FAQ. Accessed 08/April 2011
* http://www.upei.ca/~cidd/Diseases/dermatology/sebaceous%20adenitis.htm General FAQ. Accessed 08/April 2011
* http://www.edliny.com/Encyclopedy/Veterinary%20Focus/181/2.pdf More advanced introduction, diagnosis and treatments. Accessed 08/April 2011
* http://www.edliny.com/Encyclopedy/Veterinary%20Focus/181/2.pdf More advanced introduction, diagnosis and treatments. Accessed 08/April 2011
*{{cite journal |pmid=11906649}}
* http://www.ncbi.nlm.nih.gov/pubmed/11906649 "Sebaceous adenitis in the Akita: clinical observations, histopathology and heredity." Reichler IM, et.al. Accessed 08/April 2011
*{{cite journal |pages=441-3 |doi=10.1023/B:VERC.0000014199.39879.bb}}
* http://www.springerlink.com/content/u05455512617037j/ Requires access privileges. Accessed 11/April/2011
* http://onlinelibrary.wiley.com/doi/10.1046/j.0959-4493.2001.00251.x/full Requires access privileges. Accessed 11/April/2011
*{{cite journal |pages=243–53 |doi=10.1046/j.0959-4493.2001.00251.x}}
* http://www.vetwest.com.au/skin-deep-issue-so-whats-difference-between-canine-and-human-skin Explanation of the differences between Human and Canine skin. Accessed 12/April/2011
* http://www.vetwest.com.au/skin-deep-issue-so-whats-difference-between-canine-and-human-skin Explanation of the differences between Human and Canine skin. Accessed 12/April/2011
{{portal|Dogs}}
{{portal|Dogs}}

Revision as of 17:20, 13 April 2011

In canines, sebaceous adenitis, or SA, refers to the autoimmune disease found in some breeds of dog. It is an uncommon, idiopathic skin disease,[1] characterised by an immune response against the dog's sebaceous glands (glands found in the hair follicles in the skin dermis), which can lead to the destruction of the gland. It was first described in veterinary literature in the 1980s.[2]

Anatomy of human skin which shows the location of human and canine sebaceous glands

Description

Sebaceous adenitis is an autoimmune, inflammatory, skin disease of currently unknown cause. Research is curently underway to find if there is a genetic predisposition for SA, and the exact mode of inheritance remains unknown.[3] However, it is postulated that it is an autosomal recessive acquired condition.[4] It has no sex-predisposition.[1] There are two expressions of this condition, one for long or double coated breeds and one for short coated breeds, both with differing presentations.[4]

For long- or double-coated breeds such as Poodles, Akitas and Samoyeds, the condition presents itself with silvery dandruff which adheres to the coat, hair loss (not to be confused with moulting or "blowing coat"), a dull and brittle coat, and later on skin lesions along the back and ears[4] as well as thickened skin and a musty or rancid odour.[5] For short-coated breeds such as Vizslas, the condition causes facial swellings, nodular skin lesions, fine dandruff which does not adhere to the coat, and a general "moth-eaten" appearance to the coat.[4]

Etymology

Sebaceous refers to the gland which is targeted by the immune system of affected animals. Adenitis is a general term referring to the inflamation of a gland.

Susceptibility of certain breeds of dog

Certain breeds have been found to be more susceptible than others to sebaceous adenitis:

Breeds also mentioned in scientific literature as having some susceptability include:

There has also been mention of the condition in cats, rabbits[4] and horses.[9]

Diagnosis

In general, SA in canines is underdiagnosed.[1]

Treatment

There is no cure for this condition.[citation needed] Treatment is generally life-long[4] and takes the form of bathing and soaking in mineral oils and washing with antibiotic shampoos to try to alleviate symptoms and slow the condition's progression.[10] For some breeds, cyclosporine or corticosteriods and immunosuppressant drugs may be effective,[4] and it is postulated, through one study, that large doses of vitamin A given orally may result in some improvement.[4]

References

  1. ^ a b c d e : 62–8. doi:10.1111/j.2044-3862.2006.tb00066.x. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  2. ^ : 441–443. doi:10.1023/B:VERC.0000014199.39879.bb. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  3. ^ Koch, Sandra N. (June 1, 2009 – November 30, 2010). "01346-A: Genetic Basis of Sebaceous Adenitis in Dogs". University of Minnesota. Retrieved 7 April 2011.{{cite web}}: CS1 maint: date format (link)
  4. ^ a b c d e f g h i Linek, Monika (2008). "Sebaceous adenitis in the dog" (PDF). Veterinary Focus. 18 (1): 12–16. Retrieved 10 April 2011.
  5. ^ "Sebaceous Adenitis". Canine Inherited Disorders Database. 1998. Retrieved 10 April 2011.
  6. ^ a b c Pfeiffer, Ina (April 1, 2006 - June 30, 2006). "577-AT: Sebaceous Adenitis in the Akita". Retrieved 7 April 2011. {{cite web}}: Check date values in: |year= (help)
  7. ^ . PMID 18501018. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  8. ^ a b c d e f g Gross, Thelma Lee (2005). Skin diseases of the dog and cat: clinical and histopathologic diagnosis (second ed.). Wiley-Blackwell. ISBN 9780632064526. {{cite book}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)[page needed]
  9. ^ Osborne, Christina. PMID 16808233. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  10. ^ "Inflammatory Skin Disease in Dogs". Retrieved 10 April 2011.

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Sebaceous_adenitis&oldid=423888205"