Aerobactin: Difference between revisions
Content deleted Content added
c-e |
+homologues |
||
| Line 4: | Line 4: | ||
''[[Yersinia pestis]]'' contains genes relating to aerobactin, but they have been inactivated by a [[frameshift mutation]], thus ''Y. pestis'' is no longer able to synthesise aerobactin.<ref>{{cite journal |author=Forman S, Nagiec MJ, Abney J, Perry RD, Fetherston JD |title=Analysis of the aerobactin and ferric hydroxamate uptake systems of Yersinia pestis |journal=Microbiology (Reading, Engl.) |volume=153 |issue=Pt 7 |pages=2332–41 |year=2007 |month=July |pmid=17600077 |doi=10.1099/mic.0.2006/004275-0 |url=}}</ref> |
''[[Yersinia pestis]]'' contains genes relating to aerobactin, but they have been inactivated by a [[frameshift mutation]], thus ''Y. pestis'' is no longer able to synthesise aerobactin.<ref>{{cite journal |author=Forman S, Nagiec MJ, Abney J, Perry RD, Fetherston JD |title=Analysis of the aerobactin and ferric hydroxamate uptake systems of Yersinia pestis |journal=Microbiology (Reading, Engl.) |volume=153 |issue=Pt 7 |pages=2332–41 |year=2007 |month=July |pmid=17600077 |doi=10.1099/mic.0.2006/004275-0 |url=}}</ref> |
||
==Homologues== |
|||
* [[Rhizobactin]] from ''[[Sinorhizobium]]''<ref name="Cia07">{{cite journal |author=Cianciotto NP |title=Iron acquisition by Legionella pneumophila |journal=Biometals |volume=20 |issue=3-4 |pages=323–31 |year=2007 |month=June |pmid=17180462 |doi=10.1007/s10534-006-9057-4 |url=}}</ref> |
|||
* [[Alcaligin]] from ''[[Bordetella]]''<ref name="Cia07" /> |
|||
==References== |
==References== |
||
{{reflist}} |
{{reflist|2}} |
||
[[Category:Escherichia coli]] |
[[Category:Escherichia coli]] |
||
{{molecular-cell-biology-stub}} |
{{molecular-cell-biology-stub}} |
||
Revision as of 16:08, 2 May 2011
Aerobactin is a bacterial iron chelating agent (siderophore)[1] found in E. coli.[2] It is a virulence factor enabling E. coli to sequester iron in iron-poor environments, for example, the urinary tract.[3]
Aerobactin is synthesised from the oxidation of lysine, as catalysed by the aerobactin synthase enzyme. The gene for this enzyme is found in the aerobactin operon, which is roughly 8 kilobases long and contains 5 or more genes in total.[4]
Yersinia pestis contains genes relating to aerobactin, but they have been inactivated by a frameshift mutation, thus Y. pestis is no longer able to synthesise aerobactin.[5]
Homologues
- Rhizobactin from Sinorhizobium[6]
- Alcaligin from Bordetella[6]
References
- ^ J. B. Neilands (1995). "Siderophores: Structure and Function of Microbial Iron Transport Compounds". J. Biol. Chem. 270: 26723–26726. PMID 7592901.
- ^ Johnson JR, Moseley SL, Roberts PL, Stamm WE (1988). "Aerobactin and other virulence factor genes among strains of Escherichia coli causing urosepsis: association with patient characteristics". Infect Immun. 56 (2): 405–12. PMC 259296. PMID 2892793.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Meyrier A (1999). "Urinary Tract Infection". In Schrier RW, Cohen AH, Glassock RJ, Grünfeld JP (ed.). Atlas of diseases of the kidney (PDF). Vol. 2. Oxford: Blackwell Science. ISBN 0-632-04387-3.
{{cite book}}: CS1 maint: multiple names: editors list (link) - ^ de Lorenzo V, Bindereif A, Paw BH, Neilands JB (1986). "Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12". J. Bacteriol. 165 (2): 570–8. PMC 214457. PMID 2935523.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Forman S, Nagiec MJ, Abney J, Perry RD, Fetherston JD (2007). "Analysis of the aerobactin and ferric hydroxamate uptake systems of Yersinia pestis". Microbiology (Reading, Engl.). 153 (Pt 7): 2332–41. doi:10.1099/mic.0.2006/004275-0. PMID 17600077.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ a b Cianciotto NP (2007). "Iron acquisition by Legionella pneumophila". Biometals. 20 (3–4): 323–31. doi:10.1007/s10534-006-9057-4. PMID 17180462.
{{cite journal}}: Unknown parameter|month=ignored (help)
 | This molecular or cell biology article is a stub. You can help Wikipedia by expanding it. |