IRGM: Difference between revisions
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The '''IRGM gene''' is an immunity-related GTPase. |
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'''Immunity-related GTPase family M protein''' (IRGM), also known as '''interferon-inducible protein 1''' (IFI1), is an [[enyzme]] that in humans is ''IRGM'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: immunity-related GTPase family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=345611| accessdate = }}</ref> |
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IRGM is a member of the p47 immunity-related [[GTPase]] family. The encoded protein may play a role in the [[innate immune response]] by regulating [[autophagy]] formation in response to intracellular pathogens. |
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==Clinical relevance== |
==Clinical relevance== |
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Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to [[Crohn's disease]] and [[tuberculosis]].<ref name="pmid20106866">{{cite journal | author = Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, Redon R, Huang N, Stranger BE, Blaszczyk K, Hudspith B, Parkes G, Hosono N, Yamazaki K, Onnie CM, Forbes A, Dermitzakis ET, Nakamura Y, Mansfield JC, Sanderson J, Hurles ME, Roberts RG, Mathew CG | title = Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease | journal = Hum. Mol. Genet. | volume = 19 | issue = 9 | pages = 1828–39 | year = 2010 | month = May | pmid = 20106866 | pmc = 2850616 | doi = 10.1093/hmg/ddq041 }}</ref> |
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==References== |
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{{reflist}} |
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==Further reading== |
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{{refbegin | 2}} |
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*{{cite journal |author=Laukens D, Georges M, Libioulle C, ''et al.'' |title=Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis. |journal=PLoS ONE |volume=5 |issue= 11 |pages= e13795 |year= 2010 |pmid= 21072187 |doi= 10.1371/journal.pone.0013795 }} |
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*{{cite journal |author=Henckaerts L, Van Steen K, Verstreken I, ''et al.'' |title=Genetic risk profiling and prediction of disease course in Crohn's disease patients. |journal=Clin. Gastroenterol. Hepatol. |volume=7 |issue= 9 |pages= 972-980.e2 |year= 2009 |pmid= 19422935 |doi= 10.1016/j.cgh.2009.05.001 }} |
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*{{cite journal |author=Palomino-Morales RJ, Oliver J, Gómez-GarcÃa M, ''et al.'' |title=Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach. |journal=Genes Immun. |volume=10 |issue= 4 |pages= 356-64 |year= 2009 |pmid= 19491842 |doi= 10.1038/gene.2009.25 }} |
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*{{cite journal |author=Intemann CD, Thye T, Niemann S, ''et al.'' |title=Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains. |journal=PLoS Pathog. |volume=5 |issue= 9 |pages= e1000577 |year= 2009 |pmid= 19750224 |doi= 10.1371/journal.ppat.1000577 }} |
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*{{cite journal |author=Che N, Li S, Gao T, ''et al.'' |title=Identification of a novel IRGM promoter single nucleotide polymorphism associated with tuberculosis. |journal=Clin. Chim. Acta |volume=411 |issue= 21-22 |pages= 1645-9 |year= 2010 |pmid= 20547146 |doi= 10.1016/j.cca.2010.06.009 }} |
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*{{cite journal |author= , Craddock N, Hurles ME, ''et al.'' |title=Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. |journal=Nature |volume=464 |issue= 7289 |pages= 713-20 |year= 2010 |pmid= 20360734 |doi= 10.1038/nature08979 }} |
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*{{cite journal |author=Franke A, McGovern DP, Barrett JC, ''et al.'' |title=Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. |journal=Nat. Genet. |volume=42 |issue= 12 |pages= 1118-25 |year= 2010 |pmid= 21102463 |doi= 10.1038/ng.717 }} |
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*{{cite journal |author=Dema B, Fernández-Arquero M, Maluenda C, ''et al.'' |title=Lack of association of NKX2-3, IRGM, and ATG16L1 inflammatory bowel disease susceptibility variants with celiac disease. |journal=Hum. Immunol. |volume=70 |issue= 11 |pages= 946-9 |year= 2009 |pmid= 19683022 |doi= 10.1016/j.humimm.2009.08.004 }} |
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*{{cite journal |author=Zhang ZD, Frankish A, Hunt T, ''et al.'' |title=Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. |journal=Genome Biol. |volume=11 |issue= 3 |pages= R26 |year= 2010 |pmid= 20210993 |doi= 10.1186/gb-2010-11-3-r26 }} |
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*{{cite journal |author=Wolfkamp SC, Te Velde AA, Weersma RK, ''et al.'' |title=Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas? |journal=Eur J Gastroenterol Hepatol |volume=22 |issue= 8 |pages= 933-7 |year= 2010 |pmid= 20395867 |doi= 10.1097/MEG.0b013e32833775e6 }} |
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*{{cite journal |author=Singh SB, Ornatowski W, Vergne I, ''et al.'' |title=Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. |journal=Nat. Cell Biol. |volume=12 |issue= 12 |pages= 1154-65 |year= 2010 |pmid= 21102437 |doi= 10.1038/ncb2119 }} |
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*{{cite journal |author=Latiano A, Palmieri O, Corritore G, ''et al.'' |title=Variants at the 3p21 locus influence susceptibility and phenotype both in adults and early-onset patients with inflammatory bowel disease. |journal=Inflamm. Bowel Dis. |volume=16 |issue= 7 |pages= 1108-17 |year= 2010 |pmid= 20024904 |doi= 10.1002/ibd.21176 }} |
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*{{cite journal |author=Delgado M, Singh S, De Haro S, ''et al.'' |title=Autophagy and pattern recognition receptors in innate immunity. |journal=Immunol. Rev. |volume=227 |issue= 1 |pages= 189-202 |year= 2009 |pmid= 19120485 |doi= 10.1111/j.1600-065X.2008.00725.x }} |
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*{{cite journal |author=Törkvist L, Halfvarson J, Ong RT, ''et al.'' |title=Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. |journal=Inflamm. Bowel Dis. |volume=16 |issue= 6 |pages= 907-9 |year= 2010 |pmid= 19760754 |doi= 10.1002/ibd.21105 }} |
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*{{cite journal |author=Budarf ML, Goyette P, Boucher G, ''et al.'' |title=A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. |journal=Genes Immun. |volume=12 |issue= 1 |pages= 51-8 |year= 2011 |pmid= 20962850 |doi= 10.1038/gene.2010.47 }} |
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*{{cite journal |author=Bekpen C, Xavier RJ, Eichler EE |title=Human IRGM gene "to be or not to be". |journal=Semin Immunopathol |volume=32 |issue= 4 |pages= 437-44 |year= 2010 |pmid= 20737271 |doi= 10.1007/s00281-010-0224-x }} |
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*{{cite journal |author=Cleynen I, Mahachie John JM, Henckaerts L, ''et al.'' |title=Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. |journal=PLoS ONE |volume=5 |issue= 9 |pages= e12952 |year= 2010 |pmid= 20886065 |doi= 10.1371/journal.pone.0012952 }} |
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*{{cite journal |author=Wagner J, Sim WH, Ellis JA, ''et al.'' |title=Interaction of Crohn's disease susceptibility genes in an Australian paediatric cohort. |journal=PLoS ONE |volume=5 |issue= 11 |pages= e15376 |year= 2010 |pmid= 21079743 |doi= 10.1371/journal.pone.0015376 }} |
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*{{cite journal |author=Meggyesi N, Kiss LS, Koszarska M, ''et al.'' |title=NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients. |journal=World J. Gastroenterol. |volume=16 |issue= 41 |pages= 5233-40 |year= 2010 |pmid= 21049557 |doi= }} |
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{{refend}} |
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{{NLM content}} |
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{{gene-5-stub}} |
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[[Category:EC 3.6.5]] |
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Revision as of 01:14, 11 May 2011
Template:PBB Immunity-related GTPase family M protein (IRGM), also known as interferon-inducible protein 1 (IFI1), is an enyzme that in humans is IRGM gene.[1]
IRGM is a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens.
Clinical relevance
Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[2]
References
- ^ "Entrez Gene: immunity-related GTPase family".
- ^ Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, Redon R, Huang N, Stranger BE, Blaszczyk K, Hudspith B, Parkes G, Hosono N, Yamazaki K, Onnie CM, Forbes A, Dermitzakis ET, Nakamura Y, Mansfield JC, Sanderson J, Hurles ME, Roberts RG, Mathew CG (2010). "Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease". Hum. Mol. Genet. 19 (9): 1828–39. doi:10.1093/hmg/ddq041. PMC 2850616. PMID 20106866.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
Further reading
- Laukens D, Georges M, Libioulle C; et al. (2010). "Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis". PLoS ONE. 5 (11): e13795. doi:10.1371/journal.pone.0013795. PMID 21072187.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Henckaerts L, Van Steen K, Verstreken I; et al. (2009). "Genetic risk profiling and prediction of disease course in Crohn's disease patients". Clin. Gastroenterol. Hepatol. 7 (9): 972-980.e2. doi:10.1016/j.cgh.2009.05.001. PMID 19422935.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Palomino-Morales RJ, Oliver J, Gómez-GarcÃa M; et al. (2009). "Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach". Genes Immun. 10 (4): 356–64. doi:10.1038/gene.2009.25. PMID 19491842.
{{cite journal}}: Explicit use of et al. in:|author=(help); soft hyphen character in|author=at position 44 (help)CS1 maint: multiple names: authors list (link) - Intemann CD, Thye T, Niemann S; et al. (2009). "Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains". PLoS Pathog. 5 (9): e1000577. doi:10.1371/journal.ppat.1000577. PMID 19750224.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Che N, Li S, Gao T; et al. (2010). "Identification of a novel IRGM promoter single nucleotide polymorphism associated with tuberculosis". Clin. Chim. Acta. 411 (21–22): 1645–9. doi:10.1016/j.cca.2010.06.009. PMID 20547146.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - , Craddock N, Hurles ME; et al. (2010). "Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls". Nature. 464 (7289): 713–20. doi:10.1038/nature08979. PMID 20360734.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Franke A, McGovern DP, Barrett JC; et al. (2010). "Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci". Nat. Genet. 42 (12): 1118–25. doi:10.1038/ng.717. PMID 21102463.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Dema B, Fernández-Arquero M, Maluenda C; et al. (2009). "Lack of association of NKX2-3, IRGM, and ATG16L1 inflammatory bowel disease susceptibility variants with celiac disease". Hum. Immunol. 70 (11): 946–9. doi:10.1016/j.humimm.2009.08.004. PMID 19683022.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Zhang ZD, Frankish A, Hunt T; et al. (2010). "Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates". Genome Biol. 11 (3): R26. doi:10.1186/gb-2010-11-3-r26. PMID 20210993.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Wolfkamp SC, Te Velde AA, Weersma RK; et al. (2010). "Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?". Eur J Gastroenterol Hepatol. 22 (8): 933–7. doi:10.1097/MEG.0b013e32833775e6. PMID 20395867.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Singh SB, Ornatowski W, Vergne I; et al. (2010). "Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria". Nat. Cell Biol. 12 (12): 1154–65. doi:10.1038/ncb2119. PMID 21102437.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Latiano A, Palmieri O, Corritore G; et al. (2010). "Variants at the 3p21 locus influence susceptibility and phenotype both in adults and early-onset patients with inflammatory bowel disease". Inflamm. Bowel Dis. 16 (7): 1108–17. doi:10.1002/ibd.21176. PMID 20024904.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Delgado M, Singh S, De Haro S; et al. (2009). "Autophagy and pattern recognition receptors in innate immunity". Immunol. Rev. 227 (1): 189–202. doi:10.1111/j.1600-065X.2008.00725.x. PMID 19120485.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Törkvist L, Halfvarson J, Ong RT; et al. (2010). "Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients". Inflamm. Bowel Dis. 16 (6): 907–9. doi:10.1002/ibd.21105. PMID 19760754.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Budarf ML, Goyette P, Boucher G; et al. (2011). "A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles". Genes Immun. 12 (1): 51–8. doi:10.1038/gene.2010.47. PMID 20962850.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Bekpen C, Xavier RJ, Eichler EE (2010). "Human IRGM gene "to be or not to be"". Semin Immunopathol. 32 (4): 437–44. doi:10.1007/s00281-010-0224-x. PMID 20737271.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Cleynen I, Mahachie John JM, Henckaerts L; et al. (2010). "Molecular reclassification of Crohn's disease by cluster analysis of genetic variants". PLoS ONE. 5 (9): e12952. doi:10.1371/journal.pone.0012952. PMID 20886065.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Wagner J, Sim WH, Ellis JA; et al. (2010). "Interaction of Crohn's disease susceptibility genes in an Australian paediatric cohort". PLoS ONE. 5 (11): e15376. doi:10.1371/journal.pone.0015376. PMID 21079743.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Meggyesi N, Kiss LS, Koszarska M; et al. (2010). "NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients". World J. Gastroenterol. 16 (41): 5233–40. PMID 21049557.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link)
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