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Cited five key papers from http://www.gen.cam.ac.uk/research/ashburner.html
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|known_for = [[Drosophila melanogaster]]<ref name="labhandbook">{{cite book |author=Kent G. Golic; Michael Ashburner |title=Drosophila: a laboratory handbook |publisher=Cold Spring Harbor Laboratory Press |location=Plainview, N.Y |year=2005 |pages= |isbn=0-87969-706-7 |oclc= |doi= |accessdate=}}</ref><br/>[[Gene Ontology]]<ref>{{cite pmid| 10802651}}</ref><br/>[[FlyBase]]<ref name="flybase">{{cite pmid|7925011}}</ref>
|known_for = [[Drosophila melanogaster]]<ref name="labhandbook">{{cite book |author=Kent G. Golic; Michael Ashburner |title=Drosophila: a laboratory handbook |publisher=Cold Spring Harbor Laboratory Press |location=Plainview, N.Y |year=2005 |pages= |isbn=0-87969-706-7 |oclc= |doi= |accessdate=}}</ref><br/>[[Gene Ontology]]<ref name="geneontology">{{cite pmid| 10802651}}</ref><br/>[[FlyBase]]<ref name="flybase">{{cite pmid|7925011}}</ref>
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==Research on Drosophila==
==Research on Drosophila==
Most of Ashburner's research has been on the model organism ''[[Drosophila melanogaster]]''<ref name="labhandbook"/><ref>{{cite doi|10.1371/journal.pbio.0040198}}</ref><ref>{{cite book |author=Miller, Lewis F.; Michael Ashburner |title=Won for all: how the Drosophila genome was sequenced / Michael Ashburner; epilogue by R. Scott Hawley; afterword by Ethan Bier |publisher=Cold Spring Harbor Laboratory Press |location=Plainview, N.Y |year=2006 |pages= |isbn=0-87969-802-0 |oclc= |doi= |accessdate=}}</ref><ref>{{cite pmid|10731132}}</ref>. Ashburner's career began in the early period of molecular biology prior to the development of most of the techniques in use today, as recombinant [[DNA]], Northern/Southern/Western blotting. Nevertheless, by observing patterns of "puffing" in [[polytene chromosomes]]<ref>{{cite pmid|4208797}}</ref>, he established the existence of a cascade of genetic controls in the post-larval development triggered by [[ecdysone]]. The Ashburner model, of 1974, became a paradigm for [[metazoan]] gene regulation inasmuch as the [[François Jacob|Jacob]]-[[Jacques Monod|Monod]] model did for prokaryotes.
Most of Ashburner's research has been on the model organism ''[[Drosophila melanogaster]]''<ref name="labhandbook"/><ref>{{cite doi|10.1371/journal.pbio.0040198}}</ref><ref>{{cite book |author=Miller, Lewis F.; Michael Ashburner |title=Won for all: how the Drosophila genome was sequenced / Michael Ashburner; epilogue by R. Scott Hawley; afterword by Ethan Bier |publisher=Cold Spring Harbor Laboratory Press |location=Plainview, N.Y |year=2006 |pages= |isbn=0-87969-802-0 |oclc= |doi= |accessdate=}}</ref><ref>{{cite pmid|10731132}}</ref><ref>{{cite pmid|19222304}}</ref><ref>{{cite pmid|17550304}}</ref>. Ashburner's career began in the early period of molecular biology prior to the development of most of the techniques in use today, as recombinant [[DNA]], Northern/Southern/Western blotting. Nevertheless, by observing patterns of "puffing" in [[polytene chromosomes]]<ref>{{cite pmid|4208797}}</ref>, he established the existence of a cascade of genetic controls in the post-larval development triggered by [[ecdysone]]. The Ashburner model, of 1974, became a paradigm for [[metazoan]] gene regulation inasmuch as the [[François Jacob|Jacob]]-[[Jacques Monod|Monod]] model did for prokaryotes.


Ashburner was an early pioneer in the application of computers to biology. His contributions include his active participation in setting up ''[[FlyBase]]''<ref name="flybase"/> and the development of [[Open Biomedical Ontologies]]<ref name="obo">{{cite pmid|17989687}}</ref> to allow machine-searchable annotation of biological information, particularly the [[Gene Ontology]] and [[ChEBI]]<ref>{{cite pmid|17932057}}</ref>. He was also a member of the consortium that eventually sequenced and annotated the [[Drosophila melanogaster|melanogaster]] genome. A prolonged effort by his laboratory to characterise the ''[[Alcohol dehydrogenase|Adh]]'' region<ref>{{cite pmid|10471707}}</ref> became invaluable for validating annotation strategies when large-scale genome information became available.
Ashburner was an early pioneer in the application of computers to biology. His contributions include his active participation in setting up ''[[FlyBase]]''<ref name="flybase"/> and the development of [[Open Biomedical Ontologies]]<ref name="obo">{{cite pmid|17989687}}</ref> to allow machine-searchable annotation of biological information, particularly the [[Gene Ontology]]<ref name="geneontology"/><ref>{{cite pmid|19578431}}</ref> and [[ChEBI]]<ref>{{cite pmid|17932057}}</ref>. He was also a member of the consortium that eventually sequenced and annotated the [[Drosophila melanogaster|melanogaster]] genome. A prolonged effort by his laboratory to characterise the ''[[Alcohol dehydrogenase|Adh]]'' region<ref>{{cite pmid|10471707}}</ref> became invaluable for validating annotation strategies when large-scale genome information became available.


In Cambridge, Michael Ashburner and his colleagues have received funding on numerous occasions for their studies on Drosophila genomics and the development of a primer set to amplify fragments of genomic DNA highly desirable for [[chromatin]] IP, DNA binding and transcriptional profiling studies.
In Cambridge, Michael Ashburner and his colleagues have received funding on numerous occasions for their studies on Drosophila genomics and the development of a primer set to amplify fragments of genomic DNA highly desirable for [[chromatin]] IP, DNA binding and transcriptional profiling studies.

Revision as of 10:00, 29 July 2011

Michael Ashburner
Michael Ashburner
Born (1942-05-23) May 23, 1942 (age 82)[citation needed]
Sussex, England
NationalityUnited Kingdom
Alma materUniversity of Cambridge
Known forDrosophila melanogaster[4]
Gene Ontology[5]
FlyBase[6]
AwardsThomas Hunt Morgan Medal 2008[1], George W. Beadle Medal 1999[2], Benjamin Franklin Award (Bioinformatics) 2006, Accomplishment by a Senior Scientist Award 2011 [3]
Scientific career
FieldsBioinformatics
InstitutionsEuropean Bioinformatics Institute (EBI)

Michael Ashburner (FRS) (born 23 May 1942) is a biologist and emeritus Professor in the Department of Genetics at University of Cambridge[7]. He is also the former joint-head of the European Bioinformatics Institute (EBI) of the European Molecular Biology Laboratory (EMBL).

Born in Sussex, England, Ashburner attended High Wycombe Royal Grammar School from 1953 to 1960. He received his Bachelor of Arts in Natural Sciences Tripos (Genetics) in 1964, his PhD from the Department of Genetics in 1968, and was awarded a Doctor of Science in 1978, all from Cambridge[8][9].

Ashburner was elected a Foreign Honorary Member of the American Academy of Arts and Sciences in 1993.[10] He received the Gregor Mendel Medal from the Academy of Sciences, Czech Republic in 1998, the George W. Beadle Medal of the Genetics Society of America in 1999, the Genetics Society Medal of the UK Genetics Society in 2005 and the Franklin Award of the Bioinformatics Organization in 2006.

Committees he has served on include the European Drosophila Stock Centre, Sweden, Board of Management 1978-1995. He also played an important role on the National Institutes of Health Oversight Committee, Drosophila Stock Centre in Indiana 1989[citation needed].

Research on Drosophila

Most of Ashburner's research has been on the model organism Drosophila melanogaster[4][11][12][13][14][15]. Ashburner's career began in the early period of molecular biology prior to the development of most of the techniques in use today, as recombinant DNA, Northern/Southern/Western blotting. Nevertheless, by observing patterns of "puffing" in polytene chromosomes[16], he established the existence of a cascade of genetic controls in the post-larval development triggered by ecdysone. The Ashburner model, of 1974, became a paradigm for metazoan gene regulation inasmuch as the Jacob-Monod model did for prokaryotes.

Ashburner was an early pioneer in the application of computers to biology. His contributions include his active participation in setting up FlyBase[6] and the development of Open Biomedical Ontologies[17] to allow machine-searchable annotation of biological information, particularly the Gene Ontology[5][18] and ChEBI[19]. He was also a member of the consortium that eventually sequenced and annotated the melanogaster genome. A prolonged effort by his laboratory to characterise the Adh region[20] became invaluable for validating annotation strategies when large-scale genome information became available.

In Cambridge, Michael Ashburner and his colleagues have received funding on numerous occasions for their studies on Drosophila genomics and the development of a primer set to amplify fragments of genomic DNA highly desirable for chromatin IP, DNA binding and transcriptional profiling studies.

References

  1. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 18385103, please use {{cite journal}} with |pmid=18385103 instead.
  2. ^ Template:Cite pmc
  3. ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1371/journal.pcbi.1002081, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1371/journal.pcbi.1002081 instead.
  4. ^ a b Kent G. Golic; Michael Ashburner (2005). Drosophila: a laboratory handbook. Plainview, N.Y: Cold Spring Harbor Laboratory Press. ISBN 0-87969-706-7.{{cite book}}: CS1 maint: multiple names: authors list (link)
  5. ^ a b Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 10802651, please use {{cite journal}} with |pmid= 10802651 instead.
  6. ^ a b Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 7925011, please use {{cite journal}} with |pmid=7925011 instead.
  7. ^ "Michael Ashburner, Department of Genetics, University of Cambridge". Retrieved 29 July 2011.
  8. ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1016/j.cub.2006.10.010, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1016/j.cub.2006.10.010 instead.
  9. ^ Jennifer Rohn (2006). "Sequencing, sushi and sang-froid. One man's account of the fly genome project". Retrieved 29 July 2011.
  10. ^ "Book of Members, 1780-2010: Chapter A" (PDF). American Academy of Arts and Sciences. Retrieved 25 April 2011.
  11. ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1371/journal.pbio.0040198, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1371/journal.pbio.0040198 instead.
  12. ^ Miller, Lewis F.; Michael Ashburner (2006). Won for all: how the Drosophila genome was sequenced / Michael Ashburner; epilogue by R. Scott Hawley; afterword by Ethan Bier. Plainview, N.Y: Cold Spring Harbor Laboratory Press. ISBN 0-87969-802-0.{{cite book}}: CS1 maint: multiple names: authors list (link)
  13. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 10731132, please use {{cite journal}} with |pmid=10731132 instead.
  14. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19222304, please use {{cite journal}} with |pmid=19222304 instead.
  15. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 17550304, please use {{cite journal}} with |pmid=17550304 instead.
  16. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 4208797, please use {{cite journal}} with |pmid=4208797 instead.
  17. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 17989687, please use {{cite journal}} with |pmid=17989687 instead.
  18. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19578431, please use {{cite journal}} with |pmid=19578431 instead.
  19. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 17932057, please use {{cite journal}} with |pmid=17932057 instead.
  20. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 10471707, please use {{cite journal}} with |pmid=10471707 instead.

External links


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