Mir-BHRF1-3 microRNA precursor family: Difference between revisions
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The '''mir-BHRF1-3''' [[microRNA]] precursor found in Human [[herpesviridae|herpesvirus]] 4 ([[Epstein-Barr virus]]). In Epstein-Barr virus, mir-BHRF1-3 is found in the [[Three prime untranslated region|3' UTR]] of the [[BHRF1 (genetics)|BHRF1]] (Bam HI fragment H rightward open reading frame 1) [[gene]], which is known to encode a distant [[Bcl-2]] [[Homology (biology)#Homology of sequences in genetics|homolog]]. The mature sequence is excised from the 5' arm of the [[stem-loop|hairpin]].<ref name="Pfe04">{{cite journal | last = Pfeffer | first = S | coauthors = Zavolan M, Grasser FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T | year = 2004 | title = Identification of Virus-Encoded MicroRNAs | journal = Science | volume = 304 | pages = 734–736 | pmid = 15118162 | doi = 10.1126/science.1096781 | issue = 5671}}</ref> Two other miRNA precursors were found in this reading frame, namely [[Mir-BHRF1-1 microRNA precursor family|Mir-BHRF1-1]] and [[Mir-BHRF1-2 microRNA precursor family|Mir-BHRF1-2]].<ref name="Pfe04" /> |
The '''mir-BHRF1-3''' [[microRNA]] precursor found in Human [[herpesviridae|herpesvirus]] 4 ([[Epstein-Barr virus]]). In Epstein-Barr virus, mir-BHRF1-3 is found in the [[Three prime untranslated region|3' UTR]] of the [[BHRF1 (genetics)|BHRF1]] (Bam HI fragment H rightward open reading frame 1) [[gene]], which is known to encode a distant [[Bcl-2]] [[Homology (biology)#Homology of sequences in genetics|homolog]]. The mature sequence is excised from the 5' arm of the [[stem-loop|hairpin]].<ref name="Pfe04">{{cite journal | last = Pfeffer | first = S | coauthors = Zavolan M, Grasser FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T | year = 2004 | title = Identification of Virus-Encoded MicroRNAs | journal = Science | volume = 304 | pages = 734–736 | pmid = 15118162 | doi = 10.1126/science.1096781 | issue = 5671}}</ref> Two other miRNA precursors were found in this reading frame, namely [[Mir-BHRF1-1 microRNA precursor family|Mir-BHRF1-1]] and [[Mir-BHRF1-2 microRNA precursor family|Mir-BHRF1-2]].<ref name="Pfe04" /> |
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BHRF-1-3 miRNA is though to operate as part of a 'miRNA cluster' with two other microRNAs also found in the Epstein-Barr virus genome.<ref>{{cite journal|last=Feederle|first=R|coauthors=Haar, J, Bernhardt, K, Linnstaedt, SD, Bannert, H, Lips, H, Cullen, BR, Delecluse, HJ|title=The members of a viral miRNA cluster co-operate to transform B lymphocytes.|journal=Journal of virology|date=2011 Jul 13|pmid=21752900}}</ref> |
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==References== |
==References== |
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Revision as of 10:08, 5 September 2011
| Mir-BHRF1-3 microRNA precursor family | |
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| PDB structures | PDBe |
The mir-BHRF1-3 microRNA precursor found in Human herpesvirus 4 (Epstein-Barr virus). In Epstein-Barr virus, mir-BHRF1-3 is found in the 3' UTR of the BHRF1 (Bam HI fragment H rightward open reading frame 1) gene, which is known to encode a distant Bcl-2 homolog. The mature sequence is excised from the 5' arm of the hairpin.[1] Two other miRNA precursors were found in this reading frame, namely Mir-BHRF1-1 and Mir-BHRF1-2.[1]
BHRF-1-3 miRNA is though to operate as part of a 'miRNA cluster' with two other microRNAs also found in the Epstein-Barr virus genome.[2]
References
- ^ a b Pfeffer, S (2004). "Identification of Virus-Encoded MicroRNAs". Science. 304 (5671): 734–736. doi:10.1126/science.1096781. PMID 15118162.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Feederle, R (2011 Jul 13). "The members of a viral miRNA cluster co-operate to transform B lymphocytes". Journal of virology. PMID 21752900.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help)
External links
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