CADPS2: Difference between revisions
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{{PBB|geneid=93664}} |
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'''Calcium-dependent secretion activator 2''' is a [[protein]] that in humans is encoded by the ''CADPS2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CADPS2 Ca2+-dependent activator protein for secretion 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=93664| accessdate = }}</ref> |
'''Calcium-dependent secretion activator 2''' is a [[protein]] that in humans is encoded by the ''CADPS2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CADPS2 Ca2+-dependent activator protein for secretion 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=93664 | publisher = National Center for Biotechnology Information | accessdate = }}</ref> |
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Cadps2 has been linked to [[autism]]<ref name="sadakata">{{cite journal | |
Cadps2 has been linked to [[autism]] <ref name="sadakata">{{cite journal | last1=Sadakata |first1=T |title=Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients |journal=[[Journal of Clinical Investigation]] |volume=117 |issue= 4 |pages= 931–43 |year= 2007 |pmid= 17380209 |doi= 10.1172/JCI29031 | pmc=1821065 | last2=Washida | first2=M | last3=Iwayama | first3=Y | display-authors=3 | last4=Shoji | first4=Satoshi | last5=Sato | first5=Yumi | last6=Ohkura | first6=Takeshi | last7=Katoh-Semba | first7=Ritsuko | last8=Nakajima | first8=Mizuho | last9=Sekine | first9=Yukiko }}</ref> and is in the 7q autism susceptibility locus (AUTS1). However this finding was not found to be significant in another study.<ref>{{cite journal |pmid=19339759 |doi=10.1172/JCI38620 |title=Comment on "Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients" |journal=[[Journal of Clinical Investigation]] |volume=119 |issue=4 |pages=679-80 |year=2009 |month=April |first1=Alal |last1=Eran |first2=Kaitlin R. |last2=Graham |first3=Kayla |last3=Vatalaro |first4=Jillian |last4=McCarthy |first5=Christin |last5=Collins |first6=Heather |last6=Peters |first7=Stephanie J. |last7=Brewster |first8=Ellen |last8=Hanson |first9=Rachel |last9=Hundley |first10=Leonard |last10=Rappaport |first11=Ingrid A. |last11=Holm |first12=Isaac S. |last12=Kohane |first13=Louis M. |last13=Kunkel |display-authors=3}}</ref> |
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A knockout mouse model was found to have autistic-like characteristics.<ref name="sadakata" /> |
A knockout mouse model was found to have autistic-like characteristics.<ref name="sadakata" /> |
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CADPS2 has been linked to human and mouse brain structure in two large genomic studies.<ref>{{Cite journal |pmid=21253556 |title=Relationships between gene expression and brain wiring in the adult rodent brain |journal=[[PLoS Computational Biology]] |year=2011 |month=January |day=6 |volume=7 |issue=1 |last1=French |first1=L. |last2=Pavlidis |first2=P.}}</ref><ref>{{Cite journal |pmid=20171287 |title=Voxelwise genome-wide association study (vGWAS) |journal=[[Neuroimage]] |year=2010 |month=November |day=15 |volume=53 |issue=3 |pages=1160-74 |last1=Stein |first1=JL |last2=Hua |first2=X |last3=Lee |first3=S |last4=Ho |first4=AJ |last5=Leow |first5=AD |last6=Toga |first6=AW |last7=Saykin |first7=AJ |last8=Shen |first8=L |last8=Foroud |first8=T |last9=Pankratz |first9=N |last10=Huentelman |first10=MJ |last11=Craig |first11=DW |last12=Gerber |first12=JD |last13=Allen |first13=AN |last14=Corneveaux |first14=JJ |last15=Dechairo |first15=BM |last16=Potkin |first16=SG |last17=Weiner |first17=MW |last18=Thompson |first18=P |author19=Alzheimer's Disease Neuroimaging Initiative |display-authors=3}}</ref> |
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CADPS2 has been linked to human and mouse brain structure in two large genomic studies <ref>{{Cite 21253556}}</ref><ref>{{Cite 20171287}}</ref>. |
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Revision as of 02:46, 7 September 2011
Template:PBB Calcium-dependent secretion activator 2 is a protein that in humans is encoded by the CADPS2 gene.[1]
Cadps2 has been linked to autism [2] and is in the 7q autism susceptibility locus (AUTS1). However this finding was not found to be significant in another study.[3]
A knockout mouse model was found to have autistic-like characteristics.[2]
CADPS2 has been linked to human and mouse brain structure in two large genomic studies.[4][5]
References
- ^ "Entrez Gene: CADPS2 Ca2+-dependent activator protein for secretion 2". National Center for Biotechnology Information.
- ^ a b Sadakata, T; Washida, M; Iwayama, Y; et al. (2007). "Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients". Journal of Clinical Investigation. 117 (4): 931–43. doi:10.1172/JCI29031. PMC 1821065. PMID 17380209.
- ^ Eran, Alal; Graham, Kaitlin R.; Vatalaro, Kayla; et al. (2009). "Comment on "Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients"". Journal of Clinical Investigation. 119 (4): 679–80. doi:10.1172/JCI38620. PMID 19339759.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ French, L.; Pavlidis, P. (2011). "Relationships between gene expression and brain wiring in the adult rodent brain". PLoS Computational Biology. 7 (1). PMID 21253556.
{{cite journal}}: Unknown parameter|day=ignored (help); Unknown parameter|month=ignored (help) - ^ Stein, JL; Hua, X; Lee, S; et al. (2010). "Voxelwise genome-wide association study (vGWAS)". Neuroimage. 53 (3): 1160–74. PMID 20171287.
{{cite journal}}: Unknown parameter|day=ignored (help); Unknown parameter|month=ignored (help)
Further reading
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