MiR-214: Difference between revisions
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==Role in cancer== |
==Role in cancer== |
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miR-214 has been found to be downregulated in human [[cervical cancer]]; when miR-214 was upregulated in [[HeLa]] cancer cells, it was found to significantly reduce cell growth.<ref name="Yan09">{{cite journal|last=Yang|first=Z|coauthors=Chen, S, Luan, X, Li, Y, Liu, M, Li, X, Liu, T, Tang, H|title=MicroRNA-214 is aberrantly expressed in cervical cancers and inhibits the growth of HeLa cells.|journal=IUBMB life|date=2009 Nov|volume=61|issue=11|pages=1075-82|pmid=19859982}}</ref> Two [[mRNA]] targets were identified as those encoding the proteins [[MAP2K3]] and [[MAPK8]].<ref name="Yan09" /> |
miR-214 has been found to be downregulated in human [[cervical cancer]]; when miR-214 was upregulated in [[HeLa]] cancer cells, it was found to significantly reduce cell growth.<ref name="Yan09">{{cite journal|last=Yang|first=Z|coauthors=Chen, S, Luan, X, Li, Y, Liu, M, Li, X, Liu, T, Tang, H|title=MicroRNA-214 is aberrantly expressed in cervical cancers and inhibits the growth of HeLa cells.|journal=IUBMB life|date=2009 Nov|volume=61|issue=11|pages=1075-82|pmid=19859982}}</ref> Two [[mRNA]] targets were identified as those encoding the proteins [[MAP2K3]] and [[MAPK8]].<ref name="Yan09" /> |
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The increased expression of miR-214 in [[pancreatic cancer]] could bring about increased resistance to [[chemotherapy]].<ref>{{cite journal|last=Zhang|first=XJ|coauthors=Ye, H, Zeng, CW, He, B, Zhang, H, Chen, YQ|title=Dysregulation of miR-15a and miR-214 in human pancreatic cancer.|journal=Journal of hematology & oncology|date=2010 Nov 24|volume=3|pages=46|pmid=21106054}}</ref> |
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==References== |
==References== |
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Revision as of 11:10, 9 September 2011
| miR-214 | |
|---|---|
 Conserved secondary structure of miR-214 microRNA precursor | |
| Identifiers | |
| Symbol | miR-214 |
| Alt. Symbols | MIR214 |
| Rfam | RF00660 |
| miRBase | MI0000290 |
| miRBase family | MIPF0000062 |
| NCBI Gene | 406996 |
| HGNC | 31591 |
| OMIM | 610721 |
| RefSeq | NR_029627 |
| Other data | |
| RNA type | miRNA |
| Domain(s) | Metazoa |
| GO | 0035195 |
| SO | 0001244 |
| Locus | Chr. 1 q24.3 |
| PDB structures | PDBe |
miR-214 is a family of microRNA precursors found in animals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precusor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]
Function
miR-214 is a "melano-miR"[3], so-called because it is thought to encourage the metastasis of melanoma. Specifically, the mature microRNA excised from miR-214 is predicted to target two activating protein 2 transcription factors, bringing about downstream effects on a number of genes regulating vital cell cycle processes, such as apoptosis, proliferation and angiogenesis.[3]
miR-214 is also thought to regulate type-I collagen.[4]
Role in cancer
miR-214 has been found to be downregulated in human cervical cancer; when miR-214 was upregulated in HeLa cancer cells, it was found to significantly reduce cell growth.[5] Two mRNA targets were identified as those encoding the proteins MAP2K3 and MAPK8.[5]
The increased expression of miR-214 in pancreatic cancer could bring about increased resistance to chemotherapy.[6]
References
- ^ Ambros, V (2001 Dec 28). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–6. PMID 11779458.
{{cite journal}}: Check date values in:|date=(help) - ^ Gregory, RI (2005 Nov 18). "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing". Cell. 123 (4): 631–40. PMID 16271387.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ a b Bar-Eli, M (2011 May 18). "Searching for the 'melano-miRs': miR-214 drives melanoma metastasis". The EMBO journal. 30 (10): 1880–1. PMID 21593728.
{{cite journal}}: Check date values in:|date=(help) - ^ Maubach, G (2011 Jun 14). "miRNA studies in in vitro and in vivo activated hepatic stellate cells". World journal of gastroenterology : WJG. 17 (22): 2748–73. PMID 21734783.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ a b Yang, Z (2009 Nov). "MicroRNA-214 is aberrantly expressed in cervical cancers and inhibits the growth of HeLa cells". IUBMB life. 61 (11): 1075–82. PMID 19859982.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Zhang, XJ (2010 Nov 24). "Dysregulation of miR-15a and miR-214 in human pancreatic cancer". Journal of hematology & oncology. 3: 46. PMID 21106054.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help)