Panicudine: Difference between revisions
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Panicudine (6-hydroxy-11-deoxy-13 dehydrohetisane) is a C20-diterpene alkaloid of the hetisine type, first isolated from Aconitum paniculatum. It has empirical formula C20H25NO3 (molecular weight ~ 327) and a melting point of 249-250°C. The structure was determined to be a hetisine type diterpene by noting infrared spectrum absorption bands of 3405 cm-1 (OH), 1718 (C=O), and 1650 (C=C), a proton magnetic resonance spectrum with "secondary hydroxy (4.02 ppm, m, 1H, W1/2 = 10 Hz), exomethylene (4.87 and 4.76 ppm, br.s, 1H each), and tertiary methyl (1.29 ppm, s, 3H) groups and the absence of N-methyl, N-ethyl, and methoxy groups." Additional ultraviolet spectrum and carbon-13 NMR data, confirmed by high resolution mass spectroscopy, completed the determination of the structure.[1]
Panicudine was identified as an active antimicrobial substance in the chloroform extract of Polygonum aviculare, a traditional herbal medicine of the Mediterranean coastal region.[2]
References
- ^ I. A. Bessonova, Sh. A. Saidkhodzhaeva and M. F. Faskhutdinov (1995). "Panicudine — A new alkaloid from Aconitum paniculatum". Chemistry of Natural Compounds. 31 (6): 705–707. doi:10.1007/BF01386184.
- ^ Hediat M.H. Salama,
Najat Marraiki (2010-01). "Antimicrobial activity and phytochemical analyses of Polygonum aviculare L. (Polygonaceae), naturally growing in Egypt". Saudi Journal of Biological Sciences. 17 (1): 57–63.
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