Mitochondrial translational release factor 1: Difference between revisions
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'''Mitochondrial translational release factor 1''', also known as '''MTRF1''' is a human [[gene]].<ref name="pmid9838146">{{cite journal | author = Zhang Y, Spremulli LL | title = Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor | journal = Biochimica et Biophysica Acta | volume = 1443 | issue = 1-2 | pages = 245–50 | year = 1998 | month = November | pmid = 9838146 | doi = 10.1016/S0167-4781(98)00223-1 | url = | issn = }}</ref><ref name="pmid10773675">{{cite journal | author = Hansen LL, Jørgensen R, Justesen J | title = Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping | journal = Cytogenetics and Cell Genetics | volume = 88 | issue = 1-2 | pages = 91–2 | year = 2000 | pmid = 10773675 | doi = 10.1159/000015494 | url = | issn = }}</ref> |
'''Mitochondrial translational release factor 1''', also known as '''MTRF1''' is a human [[gene]].<ref name="pmid9838146">{{cite journal | author = Zhang Y, Spremulli LL | title = Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor | journal = Biochimica et Biophysica Acta | volume = 1443 | issue = 1-2 | pages = 245–50 | year = 1998 | month = November | pmid = 9838146 | doi = 10.1016/S0167-4781(98)00223-1 | url = | issn = }}</ref><ref name="pmid10773675">{{cite journal | author = Hansen LL, Jørgensen R, Justesen J | title = Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping | journal = Cytogenetics and Cell Genetics | volume = 88 | issue = 1-2 | pages = 91–2 | year = 2000 | pmid = 10773675 | doi = 10.1159/000015494 | url = | issn = }}</ref> |
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The [[protein]] encoded by this gene directs the termination of [[Translation (biology)|translation]] in response to the peptide chain [[Stop codon|termination codons]]. Initially thought to have a role in the termination of [[Mitochondrion|mitochondria]] protein synthesis. |
The [[protein]] encoded by this gene directs the termination of [[Translation (biology)|translation]] in response to the peptide chain [[Stop codon|termination codons]]. Initially thought to have a role in the termination of [[Mitochondrion|mitochondria]] protein synthesis. mtRF1 has been hypothesized to recognize non-standard stop codons AGA and AGG in vertebrates. Alternatively, based on detailed 3D modelling, it has been proposed to recognize stalled ribosomes in which a tRNA is still bound to the peptide chain, but in which the A-site of the ribosome is empty. |
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==References== |
==References== |
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*{{cite journal |author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proceedings of the National Academy of Sciences |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 }} |
*{{cite journal |author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proceedings of the National Academy of Sciences |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 }} |
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*{{cite journal |author=Soleimanpour-Lichaei HR, Kühl I, Gaisne M, ''et al.'' |title=mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG. |journal=Molecular Cell |volume=27 |issue= 5 |pages= 745–57 |year= 2007 |pmid= 17803939 |doi= 10.1016/j.molcel.2007.06.031 |pmc=1976341 }} |
*{{cite journal |author=Soleimanpour-Lichaei HR, Kühl I, Gaisne M, ''et al.'' |title=mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG. |journal=Molecular Cell |volume=27 |issue= 5 |pages= 745–57 |year= 2007 |pmid= 17803939 |doi= 10.1016/j.molcel.2007.06.031 |pmc=1976341 }} |
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*{{cite journal |author=Young DJ, Edgar CD, Murphy J, ''et al.''| title= Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria. | journal=RNA |volume= 16 |pages= 1146-55 |year= 2010 |pmid= 20421313 |
*{{cite journal |author=Young DJ, Edgar CD, Murphy J, ''et al.''| title= Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria. | journal=RNA |volume= 16 |pages= 1146-55 |year= 2010 |pmid= 20421313 }} |
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*{{cite journal|last=Huynen, MA|first=Martijn|coauthors=Duarte I, Chrzanowska-Lightowlers ZM, Nabuurs SB.|title=Structure based hypothesis of a mitochondrial ribosome rescue mechanism.|journal=Biology Direct|date=8|year=2012|month=May|volume=7|issue=1|pages=14|doi=10.1186/1745-6150-7-14|pmid=22569235}} |
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{{refend}} |
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Revision as of 14:11, 31 May 2012
Mitochondrial translational release factor 1, also known as MTRF1 is a human gene.[1][2]
The protein encoded by this gene directs the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis. mtRF1 has been hypothesized to recognize non-standard stop codons AGA and AGG in vertebrates. Alternatively, based on detailed 3D modelling, it has been proposed to recognize stalled ribosomes in which a tRNA is still bound to the peptide chain, but in which the A-site of the ribosome is empty.
References
- ^ Zhang Y, Spremulli LL (1998). "Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor". Biochimica et Biophysica Acta. 1443 (1–2): 245–50. doi:10.1016/S0167-4781(98)00223-1. PMID 9838146.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ Hansen LL, Jørgensen R, Justesen J (2000). "Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping". Cytogenetics and Cell Genetics. 88 (1–2): 91–2. doi:10.1159/000015494. PMID 10773675.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
Further reading
- Nozaki Y, Matsunaga N, Ishizawa T; et al. (2008). "HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG". Genes Cells. 13 (5): 429–38. doi:10.1111/j.1365-2443.2008.01181.x. PMID 18429816.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Dunham A, Matthews LH, Burton J; et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Soleimanpour-Lichaei HR, Kühl I, Gaisne M; et al. (2007). "mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG". Molecular Cell. 27 (5): 745–57. doi:10.1016/j.molcel.2007.06.031. PMC 1976341. PMID 17803939.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Young DJ, Edgar CD, Murphy J; et al. (2010). "Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria". RNA. 16: 1146–55. PMID 20421313.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Huynen, MA, Martijn (8). "Structure based hypothesis of a mitochondrial ribosome rescue mechanism". Biology Direct. 7 (1): 14. doi:10.1186/1745-6150-7-14. PMID 22569235.
{{cite journal}}: Check date values in:|date=and|year=/|date=mismatch (help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)CS1 maint: unflagged free DOI (link)
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