16S rRNA (guanine1405-N7)-methyltransferase: Difference between revisions
Content deleted Content added
←Created page with '{{Infobox enzyme | Name = 16S rRNA (guanine<sup>1405</sup>-N<sup>7</sup>)-methyltransferase | EC_number = 2.1.1.179 | CAS_number = | IUBMB_EC_number = 2/1/1/179...' |
(No difference)
|
Revision as of 02:10, 11 February 2013
| 16S rRNA (guanine1405-N7)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.179 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
16S rRNA (guanine1405-N7)-methyltransferase (EC 2.1.1.179, methyltransferase Sgm, m7G1405 Mtase, Sgm Mtase, Sgm, sisomicin-gentamicin methyltransferase, sisomicin-gentamicin methylase, GrmA, RmtB, RmtC, ArmA) is an enzyme with system name S-adenosyl-L-methionine:16S rRNA (guanine1405-N7)-methyltransferase.[1][2][3][4][5][6][7][8][9] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + guanine1405 in 16S rRNA S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
The enzyme specifically methylates guanine1405 at N7 in 16S rRNA.
References
- ^ Husain, N., Tkaczuk, K.L., Tulsidas, S.R., Kaminska, K.H., Cubrilo, S., Maravic-Vlahovicek, G., Bujnicki, J.M. and Sivaraman, J. (2010). "Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases". Nucleic Acids Res. 38: 4120–4132. PMID 20194115.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Savic, M., Lovric, J., Tomic, T.I., Vasiljevic, B. and Conn, G.L. (2009). "Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics". Nucleic Acids Res. 37: 5420–5431. PMID 19589804.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Tomic, T.I., Moric, I., Conn, G.L. and Vasiljevic, B. (2008). "Aminoglycoside resistance genes sgm and kgmB protect bacterial but not yeast small ribosomal subunits in vitro despite high conservation of the rRNA A-site". Res. Microbiol. 159: 658–662. PMID 18930134.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Savic, M., Ilic-Tomic, T., Macmaster, R., Vasiljevic, B. and Conn, G.L. (2008). "Critical residues for cofactor binding and catalytic activity in the aminoglycoside resistance methyltransferase Sgm". J. Bacteriol. 190: 5855–5861. PMID 18586937.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Maravic Vlahovicek, G., Cubrilo, S., Tkaczuk, K.L. and Bujnicki, J.M. (2008). "Modeling and experimental analyses reveal a two-domain structure and amino acids important for the activity of aminoglycoside resistance methyltransferase Sgm". Biochim. Biophys. Acta. 1784: 582–590. PMID 18343347.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Kojic, M., Topisirovic, L. and Vasiljevic, B. (1992). "Cloning and characterization of an aminoglycoside resistance determinant from Micromonospora zionensis". J. Bacteriol. 174: 7868–7872. PMID 1447159.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Schmitt, E., Galimand, M., Panvert, M., Courvalin, P. and Mechulam, Y. (2009). "Structural bases for 16 S rRNA methylation catalyzed by ArmA and RmtB methyltransferases". J. Mol. Biol. 388: 570–582. PMID 19303884.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Wachino, J., Shibayama, K., Kimura, K., Yamane, K., Suzuki, S. and Arakawa, Y. (2010). "RmtC introduces G1405 methylation in 16S rRNA and confers high-level aminoglycoside resistance on Gram-positive microorganisms". FEMS Microbiol. Lett. 311: 56–60. PMID 20722735.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Liou, G.F., Yoshizawa, S., Courvalin, P. and Galimand, M. (2006). "Aminoglycoside resistance by ArmA-mediated ribosomal 16S methylation in human bacterial pathogens". J. Mol. Biol. 359: 358–364. PMID 16626740.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
External links
- 16S+rRNA+(guanine1405-N7)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)