Parathyroid hormone family: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
m Disambiguated: PTH → Parathyroid hormone
Feral mage (talk | contribs)
206 edits
No edit summary
Line 22: Line 22:
}}
}}


[[Parathyroid hormone]] (PTH) is a polypeptidic hormone that elevates calcium level by dissolving the salts in bone and preventing their renal excretion. The '[[parathyroid hormone-related protein]]' (PTH-rP) is structurally related to PTH<ref name="PUB00005076">{{cite journal |author=Martin TJ, Allan EH, Caple IW, Care AD, Danks JA, Diefenbach-Jagger H, Ebeling PR, Hammonds G, Heath JA, Gillespie MT |title=Parathyroid hormone-related protein: isolation, molecular cloning, and mechanism of action |journal=Recent Prog. Horm. Res. |volume=45 |issue= |pages=467–502 |year=1989 |pmid=2682846}}</ref> and seems to play a physiological role in lactation, possibly as a hormone for the mobilization and/or transfer of calcium to the milk. PTH and PTH-rP bind to the same [[G-protein coupled receptor]].
The '''parathyroid hormone family''' is a [[protein family|family]] of structurally and functionally related [[protein]]s. [[Parathyroid hormone]] (PTH) is a polypeptidic hormone primarily involved in [[calcium metabolism]]. The [[parathyroid hormone-related protein]] (PTH-rP) is a related protein with predominantly paracrine function and possibly an endocrine role in lactation, as PTHrP has been found to be secreted by [[mammary glands]] into the circulation and increase bone turnover.<ref>{{cite journal|last=VanHouten|first=JN|coauthors=Dann, P; Stewart, AF; Watson, CJ; Pollak, M; Karaplis, AC; Wysolmerski, JJ|title=Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation.|journal=The Journal of clinical investigation|date=2003 Nov|volume=112|issue=9|pages=1429-36|pmid=14597768|url=http://www.jci.org/articles/view/19504/files/pdf}}</ref><ref>{{cite journal|last=McCauley|first=LK|coauthors=Martin, TJ|title=Twenty-five years of PTHrP progress: from cancer hormone to multifunctional cytokine.|journal=Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research|date=2012 Jun|volume=27|issue=6|pages=1231-9|pmid=22549910}}</ref> PTH and PTH-rP bind to the same [[G-protein coupled receptor]].<ref name="PUB00005076">{{cite journal |author=Martin TJ, Allan EH, Caple IW, Care AD, Danks JA, Diefenbach-Jagger H, Ebeling PR, Hammonds G, Heath JA, Gillespie MT |title=Parathyroid hormone-related protein: isolation, molecular cloning, and mechanism of action |journal=Recent Prog. Horm. Res. |volume=45 |issue= |pages=467–502 |year=1989 |pmid=2682846}}</ref> The related protein [[PTH-L]] has been found in [[teleost fish]], which also have two forms of PTH and PTHrP.<ref>{{cite journal|last=Pinheiro|first=PL|coauthors=Cardoso, JC; Gomes, AS; Fuentes, J; Power, DM; Canário, AV|title=Gene structure, transcripts and calciotropic effects of the PTH family of peptides in Xenopus and chicken.|journal=BMC evolutionary biology|date=2010 Dec 1|volume=10|pages=373|doi=10.1186/1471-2148-10-373|pmid=21122104}}</ref> Three subfamilies can be identified: PTH, PTHrP and PTH-L.<ref>{{cite journal|last=Guerreiro|first=PM|coauthors=Renfro, JL; Power, DM; Canario, AV|title=The parathyroid hormone family of peptides: structure, tissue distribution, regulation, and potential functional roles in calcium and phosphate balance in fish.|journal=American journal of physiology. Regulatory, integrative and comparative physiology|date=2007 Feb|volume=292|issue=2|pages=R679-96|pmid=17023665}}</ref>


==Subfamilies==
*[[Parathyroid hormone subtype]] {{InterPro|IPR003625}}
*[[Parathyroid hormone-related protein]] {{InterPro|IPR003626}}
==Human proteins containing this domain ==
==Human proteins containing this domain ==
[[Parathyroid hormone|PTH]]; [[PTHLH]];
[[Parathyroid hormone|PTH]]; [[PTHLH]];

Revision as of 20:55, 26 February 2013

Parathyroid hormone family
Identifiers
SymbolParathyroid
PfamPF01279
InterProIPR001415
PROSITEPDOC00296
SCOP21zwg / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1zwb :33-68 1fvyA:32-62 1bwx :32-70

1zwf :35-68 1zwg :35-68 1et1B:32-65 1hth :32-65 1zwd :34-68 1zwa :32-65 1et2A:32-65 1hpy :32-65 1zwe :35-68 1hph :32-68 1zwc :32-68 1bzg :37-70

1et3A:37-70 1m5nQ:103-130

The parathyroid hormone family is a family of structurally and functionally related proteins. Parathyroid hormone (PTH) is a polypeptidic hormone primarily involved in calcium metabolism. The parathyroid hormone-related protein (PTH-rP) is a related protein with predominantly paracrine function and possibly an endocrine role in lactation, as PTHrP has been found to be secreted by mammary glands into the circulation and increase bone turnover.[1][2] PTH and PTH-rP bind to the same G-protein coupled receptor.[3] The related protein PTH-L has been found in teleost fish, which also have two forms of PTH and PTHrP.[4] Three subfamilies can be identified: PTH, PTHrP and PTH-L.[5]

Human proteins containing this domain

PTH; PTHLH;

References

  1. ^ VanHouten, JN (2003 Nov). "Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation". The Journal of clinical investigation. 112 (9): 1429–36. PMID 14597768. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  2. ^ McCauley, LK (2012 Jun). "Twenty-five years of PTHrP progress: from cancer hormone to multifunctional cytokine". Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 27 (6): 1231–9. PMID 22549910. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  3. ^ Martin TJ, Allan EH, Caple IW, Care AD, Danks JA, Diefenbach-Jagger H, Ebeling PR, Hammonds G, Heath JA, Gillespie MT (1989). "Parathyroid hormone-related protein: isolation, molecular cloning, and mechanism of action". Recent Prog. Horm. Res. 45: 467–502. PMID 2682846.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ Pinheiro, PL (2010 Dec 1). "Gene structure, transcripts and calciotropic effects of the PTH family of peptides in Xenopus and chicken". BMC evolutionary biology. 10: 373. doi:10.1186/1471-2148-10-373. PMID 21122104. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)
  5. ^ Guerreiro, PM (2007 Feb). "The parathyroid hormone family of peptides: structure, tissue distribution, regulation, and potential functional roles in calcium and phosphate balance in fish". American journal of physiology. Regulatory, integrative and comparative physiology. 292 (2): R679-96. PMID 17023665. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
This article incorporates text from the public domain Pfam and InterPro: IPR001415
Retrieved from "https://en.wikipedia.org/w/index.php?title=Parathyroid_hormone_family&oldid=540741129"