Ure2 internal ribosome entry site (IRES): Difference between revisions
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In molecular biology, the Ure2 internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of Ure2. It allows 5' cap- and eIF4E-independent translation of an N-terminally truncated form of Ure2. This truncated form lacks the prion-forming domain.[1] It is a 104 nucleotide region, smaller than most viral IRES elements, which forms a stem-loop structure.[2] EIF2A represses this IRES resulting in an inhibition of translation of the N-terminally truncated Ure2. [3][4]
See also
References
- ^ Komar, AA (2003 Mar 3). "Internal initiation drives the synthesis of Ure2 protein lacking the prion domain and affects [URE3] propagation in yeast cells". The EMBO journal. 22 (5): 1199–209. PMID 12606584.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Reineke, LC (2008 Jul 4). "A small stem loop element directs internal initiation of the URE2 internal ribosome entry site in Saccharomyces cerevisiae". The Journal of biological chemistry. 283 (27): 19011–25. PMID 18460470.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Komar, AA (2005 Apr 22). "Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A". The Journal of biological chemistry. 280 (16): 15601–11. PMID 15718232.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Reineke, LC (2011). "Insights into the role of yeast eIF2A in IRES-mediated translation". PloS one. 6 (9): e24492. PMID 21915340.
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Further reading
- Reineke, LC (2009 Dec). "Characterization of the functional role of nucleotides within the URE2 IRES element and the requirements for eIF2A-mediated repression". RNA (New York, N.Y.). 15 (12): 2264–77. PMID 19861427.
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