Metagenomics: An Alternative Approach to Genomics: Difference between revisions
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| ⚫ | Research is going on in the field of [[genomics]].<ref name="geno">{{cite web|url=http://curiosity.discovery.com/question/human-genomo-project |title=How is the Human Genome Project helping to combat diseases? - Curiosity |publisher=Curiosity.discovery.com |date=2012-05-18 |accessdate=2013-08-17}}</ref> [[Genomics]] is helping the world to understand the surroundings in a more better way.The first organism genome to be sequenced was ''[[Saccharomyces cerevisiae]]'' (baker's yeast). Then the sequencing of the human genome opened new horizons into the study of the genomes and made the world realize that there is more and more to explore in the field of biology.<ref name="hgp">{{cite web|url=http://www.genome.gov/10001772 |title=All About The Human Genome Project (HGP) |publisher=Genome.gov |date= |accessdate=2013-08-17}}</ref> The recent applications of knowing the human genome information are many but best one of all is the curing of the diseases in human beings.<ref name="geno"/> |
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Now when researchers were thinking about how genomics can be used in studying and improving the environment , then came the field of [[metagenomics]]. The word ''metagenome'' itself tells that it is a large sample of genomes.This means that it is the sample collected from the environment or the ecosystem directly. While the traditional genomics deals with the sequencing of the cultured samples , it was found that there were some of the organisms and particularly the microorganisms for which the culturing and thus the sequencing was not possible. Thus came the field of [[metagenomics]] that helped in understanding the uncultured environmental samples such as soils from different places and areas etc. There are different applications of [[metagenomics]] which are discussed in following section. |
Now when researchers were thinking about how genomics can be used in studying and improving the environment , then came the field of [[metagenomics]]. The word ''metagenome'' itself tells that it is a large sample of genomes.This means that it is the sample collected from the environment or the ecosystem directly. While the traditional genomics deals with the sequencing of the cultured samples , it was found that there were some of the organisms and particularly the microorganisms for which the culturing and thus the sequencing was not possible. Thus came the field of [[metagenomics]] that helped in understanding the uncultured environmental samples such as soils from different places and areas etc. There are different applications of [[metagenomics]] which are discussed in following section. |
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==Soil analysis for microbial ecological studies== |
==Soil analysis for microbial ecological studies== |
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Transcriptomics analysis with the help of [[metagenomics]] is another type of work that is being done in the field of environmental studies and betterment. One of these examples is the study of Effect of Tannic Acid on the [[transcriptome]] of the Soil bacterium ''[[Pseudomonas protegens]]'' Pf-5.<ref name="study5">http://www.ncbi.nlm.nih.gov/pubmed/23435890</ref> |
Transcriptomics analysis with the help of [[metagenomics]] is another type of work that is being done in the field of environmental studies and betterment. One of these examples is the study of Effect of Tannic Acid on the [[transcriptome]] of the Soil bacterium ''[[Pseudomonas protegens]]'' Pf-5.<ref name="study5">{{cite web|author= |url=http://www.ncbi.nlm.nih.gov/pubmed/23435890 |title=Effect of tannic acid on the transcri... [Appl Environ Microbiol. 2013] - PubMed - NCBI |publisher=Ncbi.nlm.nih.gov |date=2013-03-25 |accessdate=2013-08-17}}</ref> |
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==Diagnostics and medicines== |
==Diagnostics and medicines== |
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Human Microbiome Project (HMP) confers that metagenomic analysis of [[human microbiome]] revealed various metabolic pathways in different body sites and in different modules. These included glycosaminoglycan degradation in the gut, as well as phosphate and amino acid transport linked to host phenotype in the posterior fornix. Thus [[metagenomics]] is an emrging tool in the field of diagnostics and medicines.<ref name="z">http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1002358</ref> |
Human Microbiome Project (HMP) confers that metagenomic analysis of [[human microbiome]] revealed various metabolic pathways in different body sites and in different modules. These included glycosaminoglycan degradation in the gut, as well as phosphate and amino acid transport linked to host phenotype in the posterior fornix. Thus [[metagenomics]] is an emrging tool in the field of diagnostics and medicines.<ref name="z">{{cite web|url=http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1002358 |title=PLOS Computational Biology: Metabolic Reconstruction for Metagenomic Data and Its Application to the Human Microbiome |publisher=Ploscompbiol.org |date= |accessdate=2013-08-17}}</ref> |
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==References== |
==References== |
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Revision as of 16:04, 17 August 2013
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Research is going on in the field of genomics.[1] Genomics is helping the world to understand the surroundings in a more better way.The first organism genome to be sequenced was Saccharomyces cerevisiae (baker's yeast). Then the sequencing of the human genome opened new horizons into the study of the genomes and made the world realize that there is more and more to explore in the field of biology.[2] The recent applications of knowing the human genome information are many but best one of all is the curing of the diseases in human beings.[1]
Now when researchers were thinking about how genomics can be used in studying and improving the environment , then came the field of metagenomics. The word metagenome itself tells that it is a large sample of genomes.This means that it is the sample collected from the environment or the ecosystem directly. While the traditional genomics deals with the sequencing of the cultured samples , it was found that there were some of the organisms and particularly the microorganisms for which the culturing and thus the sequencing was not possible. Thus came the field of metagenomics that helped in understanding the uncultured environmental samples such as soils from different places and areas etc. There are different applications of metagenomics which are discussed in following section.
Synergic relationship of micro-organisms with ecosystem
There are many micro-organisms that live in a symbiotic relationship with their hosts and thus it is difficult to culture them as they live in the environments which are tough to first of all be found and then to be cultured.Thus , the first application of the metagenomics is to extract those micro-organisms from their environments and thus help in sequencing the genome of those micro-organisms and making the world understand the symbiotic relationship of these micro-organisms with the ecosystem.The example of this type of study is the study on Cenarchaeum symbiosum [3]
Microbial interactions within environment
This study is important and is worth studying because all the environmental aspects are linked to it as , it only tells us and makes us know that how the micro-organisms interact with each other and thus accomplish all these environmental processes so accurately.Mutant analysis can be done for this and also this mutant analysis study has revealed that there is much more to know than has been already known.The example of this kind of study is the study on Rhizobium tropici.[4]
Wastewater treatment and other environmental studies
The metagenomics has other applications apart from understanding the ecosystem of the micro-organisms.One of these can be advanced wastewater treatment example phosphorus removal from wastewater.[5] The second application can be the study of the microbiology of biological phosphorus removal in activated sludge systems.[6]
Soil analysis for microbial ecological studies
Transcriptomics analysis with the help of metagenomics is another type of work that is being done in the field of environmental studies and betterment. One of these examples is the study of Effect of Tannic Acid on the transcriptome of the Soil bacterium Pseudomonas protegens Pf-5.[7]
Diagnostics and medicines
Human Microbiome Project (HMP) confers that metagenomic analysis of human microbiome revealed various metabolic pathways in different body sites and in different modules. These included glycosaminoglycan degradation in the gut, as well as phosphate and amino acid transport linked to host phenotype in the posterior fornix. Thus metagenomics is an emrging tool in the field of diagnostics and medicines.[8]
References
- ^ a b "How is the Human Genome Project helping to combat diseases? - Curiosity". Curiosity.discovery.com. 2012-05-18. Retrieved 2013-08-17.
- ^ "All About The Human Genome Project (HGP)". Genome.gov. Retrieved 2013-08-17.
- ^ Preston, C. M., K. Y. Wu, T. F. Molinski, and E. F. DeLong. 1996. A psychrophilic crenarchaeon inhabits a marine sponge: Cenarchaeum symbiosum gen. nov., sp. nov. Pro. Natl. Acad. Sci. USA 93:6241–6246.
- ^ Milner, J. L., R. S. Araujo, and J. Handelsman. 1992. Molecular and symbiotic characterization of exopolysaccharide-deficient mutants of Rhizobium tropici strain CIAT899. Mol. Microbiol. 6:3137–3147
- ^ Rybicki S.M. (1997). Advanced Wastewater Treatment : Phosphorus removal from Wastewater-A literature review Joint Polish-Swedish Reports. Stockholm
- ^ Seviour, R.J., Mino, T. & Onuki, M. (2003). The microbiology of biological phosphorus removal in activated sludge systems. FEMS Microbiology Reviews 27,99-127
- ^ "Effect of tannic acid on the transcri... [Appl Environ Microbiol. 2013] - PubMed - NCBI". Ncbi.nlm.nih.gov. 2013-03-25. Retrieved 2013-08-17.
- ^ "PLOS Computational Biology: Metabolic Reconstruction for Metagenomic Data and Its Application to the Human Microbiome". Ploscompbiol.org. Retrieved 2013-08-17.