IgG deficiency: Difference between revisions
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'''IgG deficiency''' ('''Selective deficiency of immunoglobulin G''') is a form of [[dysgammaglobulinemia]] where the proportional levels of the [[IgG]] isotype are reduced relative to other [[immunoglobulin]] isotypes. |
'''IgG deficiency''' ('''Selective deficiency of immunoglobulin G''') is a form of [[dysgammaglobulinemia]] where the proportional levels of the [[IgG]] isotype are reduced relative to other [[immunoglobulin]] isotypes. IgG deficiency is found often in children as transient hypogammaglobulinemia of infancy (THI), which may occur with or without additional decreases in IgA or IgM. |
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It is possible to have a deficiency of one or more specific |
IgG has four subclasses: IgG<sub>1</sub>, IgG<sub>2</sub>, IgG<sub>3</sub>, and IgG<sub>4</sub>. It is possible to have either a global IgG deficiency, or a deficiency of one or more specific subclasses of IgG.<ref name="pmid12803653">{{cite journal |author=Barton JC, Bertoli LF, Acton RT |title=HLA-A and -B alleles and haplotypes in 240 index patients with common variable immunodeficiency and selective IgG subclass deficiency in central Alabama |journal=BMC Med. Genet. |volume=4|pages=3 |date=June 2003 |pmid=12803653 |pmc=166147 |doi=10.1186/1471-2350-4-3 |url=http://www.biomedcentral.com/1471-2350/4/3}}</ref><ref name="pmid12049826">{{cite journal |author=Dhooge IJ, van Kempen MJ, Sanders LA, Rijkers GT |title=Deficient IgA and IgG2 anti-pneumococcal antibody levels and response to vaccination in otitis prone children |journal=Int. J. Pediatr. Otorhinolaryngol. |volume=64 |issue=2 |pages=133–41 |date=June 2002 |pmid=12049826 |doi= 10.1016/S0165-5876(02)00068-X|url=http://linkinghub.elsevier.com/retrieve/pii/S016558760200068X}}</ref>. The main clinically relevant form of IgG deficiency is IgG<sub>2</sub> IgG<sub>3</sub> deficiency is not usually encountered without other concomitant immunoglobulin deficiencies, and IgG<sub>4</sub> deficiency is very common but usually asymptomatic.<ref>{{cite journal|last1=Driessen|first1=G|last2=van der Burg|first2=M|title=Educational paper: primary antibody deficiencies.|journal=European journal of pediatrics|date=June 2011|volume=170|issue=6|pages=693-702|pmid=21544519}}</ref> |
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==References== |
==References== |
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Revision as of 00:36, 14 January 2015
| IgG deficiency | |
|---|---|
| Specialty | Hematology  |
IgG deficiency (Selective deficiency of immunoglobulin G) is a form of dysgammaglobulinemia where the proportional levels of the IgG isotype are reduced relative to other immunoglobulin isotypes. IgG deficiency is found often in children as transient hypogammaglobulinemia of infancy (THI), which may occur with or without additional decreases in IgA or IgM.
IgG has four subclasses: IgG1, IgG2, IgG3, and IgG4. It is possible to have either a global IgG deficiency, or a deficiency of one or more specific subclasses of IgG.[1][2]. The main clinically relevant form of IgG deficiency is IgG2 IgG3 deficiency is not usually encountered without other concomitant immunoglobulin deficiencies, and IgG4 deficiency is very common but usually asymptomatic.[3]
References
- ^ Barton JC, Bertoli LF, Acton RT (June 2003). "HLA-A and -B alleles and haplotypes in 240 index patients with common variable immunodeficiency and selective IgG subclass deficiency in central Alabama". BMC Med. Genet. 4: 3. doi:10.1186/1471-2350-4-3. PMC 166147. PMID 12803653.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Dhooge IJ, van Kempen MJ, Sanders LA, Rijkers GT (June 2002). "Deficient IgA and IgG2 anti-pneumococcal antibody levels and response to vaccination in otitis prone children". Int. J. Pediatr. Otorhinolaryngol. 64 (2): 133–41. doi:10.1016/S0165-5876(02)00068-X. PMID 12049826.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Driessen, G; van der Burg, M (June 2011). "Educational paper: primary antibody deficiencies". European journal of pediatrics. 170 (6): 693–702. PMID 21544519.
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