NTHL1: Difference between revisions
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'''Endonuclease III-like protein 1''' is an [[enzyme]] that in humans is encoded by the ''NTHL1'' [[gene]].<ref name="pmid9045706">{{cite journal | author = Hilbert TP, Chaung W, Boorstein RJ, Cunningham RP, Teebor GW | title = Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III | journal = J Biol Chem | volume = 272 | issue = 10 | pages = 6733–40 |date=Apr 1997 | pmid = 9045706 | pmc = | doi =10.1074/jbc.272.10.6733 }}</ref><ref name="pmid8990169">{{cite journal | author = Aspinwall R, Rothwell DG, Roldan-Arjona T, Anselmino C, Ward CJ, Cheadle JP, Sampson JR, Lindahl T, Harris PC, Hickson ID | title = Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 1 | pages = 109–14 |date=Feb 1997 | pmid = 8990169 | pmc = 19249 | doi =10.1073/pnas.94.1.109 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NTHL1 nth endonuclease III-like 1 (E. coli)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4913| accessdate = }}</ref> |
'''Endonuclease III-like protein 1''' is an [[enzyme]] that in humans is encoded by the ''NTHL1'' [[gene]].<ref name="pmid9045706">{{cite journal | author = Hilbert TP, Chaung W, Boorstein RJ, Cunningham RP, Teebor GW | title = Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III | journal = J Biol Chem | volume = 272 | issue = 10 | pages = 6733–40 |date=Apr 1997 | pmid = 9045706 | pmc = | doi =10.1074/jbc.272.10.6733 }}</ref><ref name="pmid8990169">{{cite journal | author = Aspinwall R, Rothwell DG, Roldan-Arjona T, Anselmino C, Ward CJ, Cheadle JP, Sampson JR, Lindahl T, Harris PC, Hickson ID | title = Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 1 | pages = 109–14 |date=Feb 1997 | pmid = 8990169 | pmc = 19249 | doi =10.1073/pnas.94.1.109 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NTHL1 nth endonuclease III-like 1 (E. coli)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4913| accessdate = }}</ref> |
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As reviewed by Li et al.,<ref name=Li>{{cite journal |vauthors=Li J, Braganza A, Sobol RW |title=Base excision repair facilitates a functional relationship between Guanine oxidation and histone demethylation |journal=Antioxid. Redox Signal. |volume=18 |issue=18 |pages=2429–43 |year=2013 |pmid=23311711 |pmc=3671628 |doi=10.1089/ars.2012.5107 |url=}}</ref> NTHL1 is a bifunctional DNA glycosylase that has an associated [[DNA-(apurinic or apyrimidinic site) lyase#Biological Function|beta-elimination]] activity. NTHL1 is usually involved in removing oxidative pyrimidine lesions through [[base excision repair]]. NTHL1 catalyses the first step in base excision repair. It cleaves the N-glycosylic bond between the damaged base and its associated sugar residue and then cleaves the phosphodiester bond 3' to the AP site,<ref name="pmid21930793">{{cite journal |vauthors=Odell ID, Barbour JE, Murphy DL, Della-Maria JA, Sweasy JB, Tomkinson AE, Wallace SS, Pederson DS |title=Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair |journal=Mol. Cell. Biol. |volume=31 |issue=22 |pages=4623–32 |year=2011 |pmid=21930793 |pmc=3209256 |doi=10.1128/MCB.05715-11 |url=}}</ref> leaving a 3'-unsaturated aldehyde after beta-elimination and a 5'-phosphate at the termini of the repair gap.<ref name=Li /> |
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Low expression of NTHL1 is associated with initiation and development of astrocytoma.<ref name="pmid17034947">{{cite journal |vauthors=Jiang Z, Hu J, Li X, Jiang Y, Zhou W, Lu D |title=Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array |journal=Neurosci. Lett. |volume=409 |issue=2 |pages=112–7 |year=2006 |pmid=17034947 |doi=10.1016/j.neulet.2006.09.038 |url=}}</ref> Low expression of NTHL1 is also found in follicular thyroid tumors.<ref name="pmid22331172">{{cite journal |vauthors=Karger S, Krause K, Engelhardt C, Weidinger C, Gimm O, Dralle H, Sheu-Grabellus SY, Schmid KW, Fuhrer D |title=Distinct pattern of oxidative DNA damage and DNA repair in follicular thyroid tumours |journal=J. Mol. Endocrinol. |volume=48 |issue=3 |pages=193–202 |year=2012 |pmid=22331172 |doi=10.1530/JME-11-0119 |url=}}</ref> |
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A germ line homozygous mutation in ''NTHL1'' causes a cancer susceptibility syndrome similar to [[Hereditary nonpolyposis colorectal cancer|Lynch syndrome]].<ref name="pmid26431160">{{cite journal |vauthors=Kuiper RP, Hoogerbrugge N |title=NTHL1 defines novel cancer syndrome |journal=Oncotarget |volume= |issue= |pages= |year=2015 |pmid=26431160 |doi= |url=}}</ref><ref name="pmid25938944">{{cite journal |vauthors=Weren RD, Ligtenberg MJ, Kets CM, de Voer RM, Verwiel ET, Spruijt L, van Zelst-Stams WA, Jongmans MC, Gilissen C, Hehir-Kwa JY, Hoischen A, Shendure J, Boyle EA, Kamping EJ, Nagtegaal ID, Tops BB, Nagengast FM, Geurts van Kessel A, van Krieken JH, Kuiper RP, Hoogerbrugge N |title=A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer |journal=Nat. Genet. |volume=47 |issue=6 |pages=668–71 |year=2015 |pmid=25938944 |doi=10.1038/ng.3287 |url=}}</ref> |
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Revision as of 20:39, 5 October 2015
Template:PBB Endonuclease III-like protein 1 is an enzyme that in humans is encoded by the NTHL1 gene.[1][2][3]
As reviewed by Li et al.,[4] NTHL1 is a bifunctional DNA glycosylase that has an associated beta-elimination activity. NTHL1 is usually involved in removing oxidative pyrimidine lesions through base excision repair. NTHL1 catalyses the first step in base excision repair. It cleaves the N-glycosylic bond between the damaged base and its associated sugar residue and then cleaves the phosphodiester bond 3' to the AP site,[5] leaving a 3'-unsaturated aldehyde after beta-elimination and a 5'-phosphate at the termini of the repair gap.[4]
Low expression of NTHL1 is associated with initiation and development of astrocytoma.[6] Low expression of NTHL1 is also found in follicular thyroid tumors.[7]
A germ line homozygous mutation in NTHL1 causes a cancer susceptibility syndrome similar to Lynch syndrome.[8][9]
References
- ^ Hilbert TP, Chaung W, Boorstein RJ, Cunningham RP, Teebor GW (Apr 1997). "Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III". J Biol Chem. 272 (10): 6733–40. doi:10.1074/jbc.272.10.6733. PMID 9045706.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Aspinwall R, Rothwell DG, Roldan-Arjona T, Anselmino C, Ward CJ, Cheadle JP, Sampson JR, Lindahl T, Harris PC, Hickson ID (Feb 1997). "Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III". Proc Natl Acad Sci U S A. 94 (1): 109–14. doi:10.1073/pnas.94.1.109. PMC 19249. PMID 8990169.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: NTHL1 nth endonuclease III-like 1 (E. coli)".
- ^ a b Li J, Braganza A, Sobol RW (2013). "Base excision repair facilitates a functional relationship between Guanine oxidation and histone demethylation". Antioxid. Redox Signal. 18 (18): 2429–43. doi:10.1089/ars.2012.5107. PMC 3671628. PMID 23311711.
- ^ Odell ID, Barbour JE, Murphy DL, Della-Maria JA, Sweasy JB, Tomkinson AE, Wallace SS, Pederson DS (2011). "Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair". Mol. Cell. Biol. 31 (22): 4623–32. doi:10.1128/MCB.05715-11. PMC 3209256. PMID 21930793.
- ^ Jiang Z, Hu J, Li X, Jiang Y, Zhou W, Lu D (2006). "Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array". Neurosci. Lett. 409 (2): 112–7. doi:10.1016/j.neulet.2006.09.038. PMID 17034947.
- ^ Karger S, Krause K, Engelhardt C, Weidinger C, Gimm O, Dralle H, Sheu-Grabellus SY, Schmid KW, Fuhrer D (2012). "Distinct pattern of oxidative DNA damage and DNA repair in follicular thyroid tumours". J. Mol. Endocrinol. 48 (3): 193–202. doi:10.1530/JME-11-0119. PMID 22331172.
- ^ Kuiper RP, Hoogerbrugge N (2015). "NTHL1 defines novel cancer syndrome". Oncotarget. PMID 26431160.
- ^ Weren RD, Ligtenberg MJ, Kets CM, de Voer RM, Verwiel ET, Spruijt L, van Zelst-Stams WA, Jongmans MC, Gilissen C, Hehir-Kwa JY, Hoischen A, Shendure J, Boyle EA, Kamping EJ, Nagtegaal ID, Tops BB, Nagengast FM, Geurts van Kessel A, van Krieken JH, Kuiper RP, Hoogerbrugge N (2015). "A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer". Nat. Genet. 47 (6): 668–71. doi:10.1038/ng.3287. PMID 25938944.
Further reading
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