Timeline of cancer treatment development: Difference between revisions

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===1900s===
===1900s===
* 1900 {{spaced ndash}} Swedish Dr. Stenbeck, cures a skin cancer with small doses of radiation<ref name=raconteur/>
* 1900 {{spaced ndash}} Swedish Dr. Stenbeck, cures a skin cancer with small doses of radiation<ref name=raconteur/>
* 1941 {{spaced ndash}} American Dr. Charles Huggins uses synthetic hormone therapy to treat prostate cancer<ref name=curetoday/>
* 1939 {{spaced ndash}} American Dr. Charles Huggins uses synthetic hormone therapy to treat prostate cancer<ref name=curetoday/>
* 1942 {{spaced ndash}} First chemotherapy drug [[ mustine ]] used to treat cancer <ref>{{cite journal | title = First Use of Intravenous Chemotherapy Cancer Treatment: Rectifying the Record.| url=http://www.journalacs.org/article/S1072-7515%2810%2901211-1/abstract}}</ref>
* 1942 {{spaced ndash}} First chemotherapy drug [[ mustine ]] used to treat cancer <ref>{{cite journal | title = First Use of Intravenous Chemotherapy Cancer Treatment: Rectifying the Record.| url=http://www.journalacs.org/article/S1072-7515%2810%2901211-1/abstract}}</ref>
* 1947 {{spaced ndash}} American Dr. Farber induces brief remission in a patient with leukaemia with the antifolate drug [[aminopterin]] ([[methotrexate]]) <ref name=raconteur/>
* 1947 {{spaced ndash}} American Dr. Farber induces brief remission in a patient with leukaemia with the antifolate drug [[aminopterin]] ([[methotrexate]]) <ref name=raconteur/>
* 1949 {{spaced ndash}} Oncolytic viruses began human clinical trials <ref>{{cite web|title=Clinical virotherapy: four historically significant clinical trials|url=http://www.nature.com/mt/journal/v15/n4/fig_tab/6300108t1.html#figure-title}}</ref><ref>{{cite journal|last=Huebner|first=RJ|author2=Rowe, WP |author3=Schatten, WE |author4=Smith, RR |author5= Thomas, LB |title=Studies on the use of viruses in the treatment of carcinoma of the cervix|journal=Cancer|date=Nov–Dec 1956|volume=9|issue=6|pages=1211–8|pmid=13383455|url=http://www.ncbi.nlm.nih.gov/pubmed/13383455?dopt=Abstract&holding=npg|doi=10.1002/1097-0142(195611/12)9:6<1211::AID-CNCR2820090624>3.0.CO;2-7}}</ref>
* 1949 {{spaced ndash}} US FDA approves nitrogen mustard ([[mechlorethamine]]) for treatment of cancer <ref name=Milestones>{cite web|title=Milestones in Cancer Research and Discovery|url=https://www.cancer.gov/research/progress/250-years-milestones}}</ref>
* 1949 {{spaced ndash}} [[Oncolytic viruses]] began human clinical trials <ref>{{cite web|title=Clinical virotherapy: four historically significant clinical trials|url=http://www.nature.com/mt/journal/v15/n4/fig_tab/6300108t1.html#figure-title}}</ref><ref>{{cite journal|last=Huebner|first=RJ|author2=Rowe, WP |author3=Schatten, WE |author4=Smith, RR |author5= Thomas, LB |title=Studies on the use of viruses in the treatment of carcinoma of the cervix|journal=Cancer|date=Nov–Dec 1956|volume=9|issue=6|pages=1211–8|pmid=13383455|url=http://www.ncbi.nlm.nih.gov/pubmed/13383455?dopt=Abstract&holding=npg|doi=10.1002/1097-0142(195611/12)9:6<1211::AID-CNCR2820090624>3.0.CO;2-7}}</ref>
* 1951 {{spaced ndash}} Dr. Jane C. Wright demonstrated the use of the antifolate, [[methotrexate]] in solid tumors, showing remission in breast cancer<ref name=raconteur/>
* 1951 {{spaced ndash}} Dr. Jane C. Wright demonstrated the use of the antifolate, [[methotrexate]] in solid tumors, showing remission in breast cancer<ref name=raconteur/>
* 1950s {{spaced ndash}} [[Anthracycline]], anti-cancer alkoloid, isolated from the [[Streptomyces peucetius]] bacteria. Anthracycline-based derivatives include: [[daunorubicin]], [[ doxorubicin ]], [[amrubicin]], [[idarubicin]] <ref>{{Cite journal | last1 = Fujiwara | first1 = A.| last2 = Hoshino | first2 = T. | last3 = Westley | first3 = J. W. | doi = 10.3109/07388558509150782 | title = Anthracycline Antibiotics | journal = Critical Reviews in Biotechnology | volume = 3 | issue = 2 | pages = 133 | year = 1985 | pmid = | pmc = }}</ref>
* 1950s {{spaced ndash}} [[Anthracycline]], anti-cancer alkoloid, isolated from the [[Streptomyces peucetius]] bacteria. Anthracycline-based derivatives include: [[daunorubicin]], [[ doxorubicin ]], [[amrubicin]], [[idarubicin]] <ref>{{Cite journal | last1 = Fujiwara | first1 = A.| last2 = Hoshino | first2 = T. | last3 = Westley | first3 = J. W. | doi = 10.3109/07388558509150782 | title = Anthracycline Antibiotics | journal = Critical Reviews in Biotechnology | volume = 3 | issue = 2 | pages = 133 | year = 1985 | pmid = | pmc = }}</ref>
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* 1957 {{spaced ndash}} Introduction of [[fluorouracil]] to treat colorectal, breast, stomach, and pancreatic cancers<ref name=curetoday/>
* 1957 {{spaced ndash}} Introduction of [[fluorouracil]] to treat colorectal, breast, stomach, and pancreatic cancers<ref name=curetoday/>
* 1957 {{spaced ndash}} Introduction of [[interferon]] to treat kidney, skin, and bladder cancer<ref name=curetoday/>
* 1957 {{spaced ndash}} Introduction of [[interferon]] to treat kidney, skin, and bladder cancer<ref name=curetoday/>
* 1958 {{spaced ndash}} [[Combination therapy]] (several drugs at once) results in a cure of leukaemia in a trial run in US hospitals<ref name=raconteur/>
* 1958 {{spaced ndash}} [[Combination therapy]] consisting of [[6-mercaptopurine]] and [[methotrexate]] results in a cure of leukaemia in a trial run in US hospitals<ref name=raconteur/><ref name=Milestones/>
* 2007 {{spaced ndash}} US FDA approves [[cyclophosphamide]] for chemotherapy of cancer<ref name="pmid19786984">{{cite journal | vauthors = Emadi A, Jones RJ, Brodsky RA | title = Cyclophosphamide and cancer: golden anniversary | journal = Nat Rev Clin Oncol | volume = 6 | issue = 11 | pages = 638–47 | year = 2009 | pmid = 19786984 | doi = 10.1038/nrclinonc.2009.146 | url = }}</ref>
* 1958 {{spaced ndash}} US FDA approves [[cyclophosphamide]] for chemotherapy of cancer<ref name="pmid19786984">{{cite journal | vauthors = Emadi A, Jones RJ, Brodsky RA | title = Cyclophosphamide and cancer: golden anniversary | journal = Nat Rev Clin Oncol | volume = 6 | issue = 11 | pages = 638–47 | year = 2009 | pmid = 19786984 | doi = 10.1038/nrclinonc.2009.146 | url = }}</ref>
* 1960s {{spaced ndash}} Introduction of laser therapy in treatment of cancer <ref>{{cite journal | year = 1966 |title =A review: Applications of the laser beam in cancer biology. | author = Goldman| url=http://onlinelibrary.wiley.com/doi/10.1002/ijc.2910010402/full}}</ref>
* 1960s {{spaced ndash}} Introduction of laser therapy in treatment of cancer <ref>{{cite journal | year = 1966 |title =A review: Applications of the laser beam in cancer biology. | author = Goldman| url=http://onlinelibrary.wiley.com/doi/10.1002/ijc.2910010402/full}}</ref>
* 1960 {{spaced ndash}} Invention of [[tamoxifen]] breast cancer [[anti-estrogen]] ([[Selective estrogen receptor modulator|SERM]]) [[hormonal therapy]] drug
* 1960 {{spaced ndash}} Invention of [[tamoxifen]] breast cancer [[anti-estrogen]] ([[Selective estrogen receptor modulator|SERM]]) [[hormonal therapy]] drug
* 1961 {{spaced ndash}} [[Vincristine]], anti-cancer alkoloid, isolated from the [[Madagascar periwinkle]] plant <ref name=Rav2011>{{cite book|last1=Ravina|first1=Enrique|title=The evolution of drug discovery : from traditional medicines to modern drugs|date=2011|publisher=Wiley-VCH|location=Weinheim|isbn=9783527326693|pages=157–159|edition=1. Aufl.|url=https://books.google.ca/books?id=iDNy0XxGqT8C&pg=PA157}}</ref>
* 1961 {{spaced ndash}} [[Vincristine]], anti-cancer alkoloid, isolated from the [[Madagascar periwinkle]] plant <ref name=Rav2011>{{cite book|last1=Ravina|first1=Enrique|title=The evolution of drug discovery : from traditional medicines to modern drugs|date=2011|publisher=Wiley-VCH|location=Weinheim|isbn=9783527326693|pages=157–159|edition=1. Aufl.|url=https://books.google.ca/books?id=iDNy0XxGqT8C&pg=PA157}}</ref>
* 1963 {{spaced ndash}} US FDA approves [[vincristine]] (Oncovin) for chemotherapy of cancer <ref name=Rav2011/>
* 1963 {{spaced ndash}} US FDA approves [[vincristine]] (Oncovin) for chemotherapy of cancer <ref name=Rav2011/>
* 1964 {{spaced ndash}} VAMP regimen [[combination therapy]], consisting of: [[vincristine]], [[amethopterin]], [[ 6-mercaptopurine]], and [[prednisone]], induces long-term remissions in juvenille acute lymphoblastic leukemia<ref name=a1158>{{cite web | title = A History of Cancer Chemotherapy | url=http://cancerres.aacrjournals.org/content/68/21/8643}}</ref>
* 1965 {{spaced ndash}} American Dr. Vincent DeVita at the US National Cancer Institute utilize [[combination therapy]] to cure advanced Hodgkin’s lymphoma<ref name=raconteur/>
* 1965 {{spaced ndash}} MOPP regimen [[combination therapy]] cures advanced Hodgkin’s lymphoma, with the combination of: nitrogen mustard, vincristine, procarbazine, and prednisone<ref name=raconteur/><ref name=curetoday/>
* 1965 {{spaced ndash}} MOMP regimen [[combination therapy]], consisting of: [[methotrexate]], [[vincristine]], [[6-MP]], and [[prednisone]], induces long-term remissions in juvenille acute lymphoblastic leukemia<ref name=curetoday/><ref name=a1158/>
* 1965 {{spaced ndash}} USSR develops [[RIGVIR]], oncological [[virotherapy]] <ref name=MB1982>Muceniece A.J., Bumbieris J.V. 1982. Transplantation antigens and their changes in carcinogenesis and viral infection. In: Virusnyi onkoliz i iskusstvennaya geterogenizatsiya opukholei (Viral Oncolysis and Artificial Heterogenization of Tumors). Riga, pp. 217–234.</ref>
* 1965 {{spaced ndash}} USSR develops [[RIGVIR]], oncological [[virotherapy]] <ref name=MB1982>Muceniece A.J., Bumbieris J.V. 1982. Transplantation antigens and their changes in carcinogenesis and viral infection. In: Virusnyi onkoliz i iskusstvennaya geterogenizatsiya opukholei (Viral Oncolysis and Artificial Heterogenization of Tumors). Riga, pp. 217–234.</ref>
* 1966 {{spaced ndash}} [[Taxol]], anti-cancer compound, isolated from the [[yew]] plant
* 1966 {{spaced ndash}} [[Taxol]], anti-cancer compound, isolated from the [[yew]] plant
* 1967 {{spaced ndash}} [[Camptothecin]], powerful anti-cancer compound, isolated from the [[Camptotheca acuminata]], Chinese Happy tree, which was used as a cancer treatment in Traditional Chinese Medicine.<ref> the stem bark of Mappia foetida , a tree native to India, has proved to be another source significant for the isolation of camptothecin.TR Govindachari and N. Viswnathan, Phytochemistry,11(12), 3529-31 (1972)). {{Cite journal|vauthors=Efferth T, Fu YJ, Zu YG, Schwarz G, Konkimalla VS, Wink M | title = Molecular target-guided tumor therapy with natural products derived from traditional Chinese medicine. | year = 2007 | journal = Current medicinal chemistry | volume = 14 | pages = 2024–32 | url = | doi = 10.2174/092986707781368441| issue = 19 }}</ref>. It is the source of chemotherapy drugs: [[Hycamtin]] and [[ irinotecan ]].
* 1967 {{spaced ndash}} [[Camptothecin]], anti-cancer compound, isolated from the [[Camptotheca acuminata]], Chinese Happy tree, which was used as a cancer treatment in Traditional Chinese Medicine.<ref> the stem bark of Mappia foetida , a tree native to India, has proved to be another source significant for the isolation of camptothecin.TR Govindachari and N. Viswnathan, Phytochemistry,11(12), 3529-31 (1972)). {{Cite journal|vauthors=Efferth T, Fu YJ, Zu YG, Schwarz G, Konkimalla VS, Wink M | title = Molecular target-guided tumor therapy with natural products derived from traditional Chinese medicine. | year = 2007 | journal = Current medicinal chemistry | volume = 14 | pages = 2024–32 | url = | doi = 10.2174/092986707781368441| issue = 19 }}</ref>. It is the source of chemotherapy drugs: [[Hycamtin]] and [[ irinotecan ]].
* 1968 {{spaced ndash}} Japanese Dr. Tanaka pioneers the treatment of metastatic [[ breast cancer]] with [[ cryoablation ]] <ref>{{cite journal | year = 1982 |title = Immunological aspects of cryosurgery in general surgery.| journal = Cryobiology | author = Tanaka| url=https://www.ncbi.nlm.nih.gov/pubmed/7105777}}</ref><ref>{{cite journal | year = 1998 |title = The Use of Cryosurgery for Breast Cancer | url=http://archsurg.jamanetwork.com/article.aspx?articleid=211464 | journal = Arch Surg | language = en|author = Richard J. Ablin, PhD}}</ref>
* 1968 {{spaced ndash}} Japanese Dr. Tanaka pioneers the treatment of metastatic [[ breast cancer]] with [[cryoablation]], resulting in prolonged survival <ref>{{cite journal | year = 1982 |title = Immunological aspects of cryosurgery in general surgery.| journal = Cryobiology | author = Tanaka| url=https://www.ncbi.nlm.nih.gov/pubmed/7105777}}</ref><ref>{{cite journal | year = 1998 |title = The Use of Cryosurgery for Breast Cancer | url=http://archsurg.jamanetwork.com/article.aspx?articleid=211464 | journal = Arch Surg | language = en|author = Richard J. Ablin, PhD}}</ref><ref name=PMC4115762/>
* 1972 {{spaced ndash}} UK and other European countries approve [[tamoxifen]] for breast cancer
* 1972 {{spaced ndash}} UK and other European countries approve [[tamoxifen]] for breast cancer
* 1972 {{spaced ndash}} American Dr. Lawrence Einhorn cures metastatic testicular cancer with [[cisplatin]] <ref name=curetoday>{{cite web |title = Timeline: Milestones in Cancer Treatment | url=http://www.curetoday.com/publications/cure/2008/special-issue2008/timeline-milestones-in-cancer-treatment}}</ref>
* 1972 {{spaced ndash}} American Dr. Lawrence Einhorn cures metastatic testicular cancer with [[cisplatin]] <ref name=curetoday>{{cite web |title = Timeline: Milestones in Cancer Treatment | url=http://www.curetoday.com/publications/cure/2008/special-issue2008/timeline-milestones-in-cancer-treatment}}</ref>
* 1975 {{spaced ndash}} Invention of [[monoclonal antibodies]]<ref name=raconteur/>
* 1975 {{spaced ndash}} Invention of [[monoclonal antibodies]]<ref name=raconteur/>
* 1975 {{spaced ndash}} American Dr. Einhorn shows [[combination therapy]] can cure 70 per cent of advanced testicular cancer cases<ref name=raconteur/>
* 1975 {{spaced ndash}} American Dr. Einhorn shows [[combination therapy]] consisting of [[cis-platinum]], [[vinblastine]], and [[bleomycin]] can cure 70 per cent of advanced testicular cancer cases<ref name=a1158/>
* 1975 {{spaced ndash}} C-MOPP regimen [[combination therapy]], consisting of: [[methotrexate]], [[vincristine]], [[cyclophosphamide]], and [[prednisone]], cured advanced diffuse large B-cell lymphoma<ref name=a1158/>
* 1977 {{spaced ndash}} US FDA approves [[tamoxifen]] for metatstatic breast cancer only, not widely popular as chemotherapy remains first line of treatment <ref>{{cite book | title = Tamoxifen: Pioneering Medicine in Breast Cancer.| url=https://books.google.com/books?id=p-W5BAAAQBAJ&pg=PA186}}</ref> <ref>Tamoxifen was born into a world of indifference in the '60s, when the focus of the research was on contraception. It grew up in the 70s, in a world where chemotherapy was king and hormonal therapies were perceived as non-starters in the quest to cure cancer.{{cite book | title = Tamoxifen: a personal retrospective.| url=http://www.thelancetnorway.com/pdfs/journals/lanonc/PIIS1470-2045(00)00009-7.pdf}}</ref>
* 1977 {{spaced ndash}} US FDA approves [[tamoxifen]] for metatstatic breast cancer only, not widely popular as chemotherapy remains first line of treatment <ref>{{cite book | title = Tamoxifen: Pioneering Medicine in Breast Cancer.| url=https://books.google.com/books?id=p-W5BAAAQBAJ&pg=PA186}}</ref> <ref>Tamoxifen was born into a world of indifference in the '60s, when the focus of the research was on contraception. It grew up in the 70s, in a world where chemotherapy was king and hormonal therapies were perceived as non-starters in the quest to cure cancer.{{cite book | title = Tamoxifen: a personal retrospective.| url=http://www.thelancetnorway.com/pdfs/journals/lanonc/PIIS1470-2045(00)00009-7.pdf}}</ref>
* 1981 {{spaced ndash}} American Dr. Fisher proves [[lumpectomy]] is as effective as mastectomy for breast cancer <ref name=raconteur/>
* 1981 {{spaced ndash}} American Dr. Fisher proves [[lumpectomy]] is as effective as mastectomy for breast cancer <ref name=raconteur/>
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* 1990 {{spaced ndash}} USSR begins treating patients with various kinds of cancer with [[Rigvir]] [[virotherapy]]
* 1990 {{spaced ndash}} USSR begins treating patients with various kinds of cancer with [[Rigvir]] [[virotherapy]]
* 1990 {{spaced ndash}} US FDA approves [[tamoxifen]] for major additional use to help prevent the recurrence of cancer in "node-negative" patients <ref>{{cite web |title = Center for Devices and Radiological Health U.S. Food and Drug Administration. | url=http://www.fda.gov/ohrms/dockets/ac/03/briefing/3973b1_summary.htm}}</ref>
* 1990 {{spaced ndash}} US FDA approves [[tamoxifen]] for major additional use to help prevent the recurrence of cancer in "node-negative" patients <ref>{{cite web |title = Center for Devices and Radiological Health U.S. Food and Drug Administration. | url=http://www.fda.gov/ohrms/dockets/ac/03/briefing/3973b1_summary.htm}}</ref>
* 1990 {{spaced ndash}} China begins treating various cancers with [[photodynamic therapy]] <ref>{{Cite journal| volume = 3| pages = 3–10| last = Huang| first = Z| title = Photodynamic therapy in China: Over 25 years of unique clinical experience: Part One—History and domestic photosensitizers| journal = Photodiagnosis and Photodynamic Therapy| year = 2006| doi = 10.1016/S1572-1000(06)00009-3}}<br />
{{Cite journal| volume = 4| pages = 13–25| last = Xu| first = DY| title = Research and development of photodynamic therapy photosensitizers in China | journal = Photodiagnosis and Photodynamic Therapy| year = 2007| doi = 10.1016/j.pdpdt.2006.09.003}}
</ref>
* 1991 {{spaced ndash}} First [[gene therapy]] treatment of cancer (melanoma)
* 1991 {{spaced ndash}} First [[gene therapy]] treatment of cancer (melanoma)
* 1992 {{spaced ndash}} Invention of tyrosine-kinase inhibitor [[Imatinib]] <ref>{{cite web |title = The Story of Gleevec | url=http://web.archive.org/web/20131021011042/http://www.innovation.org/index.cfm/StoriesofInnovation/InnovatorStories/The_Story_of_Gleevec}}</ref>
* 1992 {{spaced ndash}} Invention of tyrosine-kinase inhibitor [[Imatinib]] <ref>{{cite web |title = The Story of Gleevec | url=http://web.archive.org/web/20131021011042/http://www.innovation.org/index.cfm/StoriesofInnovation/InnovatorStories/The_Story_of_Gleevec}}</ref>
* 1996 {{spaced ndash}} US FDA approves antiestrogen, aromatase inhibitor [[ Anastrozole]] for advanced breast cancer <ref name=Milestones/>
* 1996 {{spaced ndash}} Russia begins treating various cancers with [[photodynamic therapy]] <ref name="magicray">{{Cite web| title = Centre of laser medicine — Historical Aspects of Photodynamic Therapy Development| accessdate = 2011-08-05| url = http://www.magicray.ru/ENG/lecture/L2/2.html}}
</ref>
* 1997 {{spaced ndash}} First [[monoclonal antibody]], [[Rituximab]], is licensed<ref name=raconteur/>
* 1997 {{spaced ndash}} First [[monoclonal antibody]], [[Rituximab]], is licensed<ref name=raconteur/>
* 1997 {{spaced ndash}} China starts treating uterine fibroids, liver cancer, breast cancer, pancreatic cancer, bone tumors, and renal cancer with ultrasound imaging-guided [[HIFU]] <ref>In 1997, a patient with osteosarcoma was first successfully treated with ultrasound imaging-guided HIFU in Chongqing, China. Over the last decade, thousands of patients with uterine fibroids, liver cancer, breast cancer, pancreatic cancer, bone tumors, and renal cancer have been treated with ultrasound imaging-guided HIFU. Based on several research groups’ reports, as well as our ten-year clinical experience, we conclude that this technique is safe and effective in treating human solid tumors.{{cite journal | year = 2010 |title = High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience. | url=http://link.springer.com/article/10.1007/s11684-010-0092-8}}</ref>
* 1998 {{spaced ndash}} China starts treating breast, kidney, lung, liver, prostate and bone cancer with imaging-guided [[cryoablation]] <ref>{{cite book | year = 1997 |title = History of Cryosurgery. | url=http://www.fudahospital.com/alb_asp_new/show_crosurgery_book.asp?page=crosurgery_1_1}}</ref> <ref>{{cite web |title = FAQ | url=http://keepingthem.com/faq/}}</ref>
* 1998 {{spaced ndash}} US FDA approves [[herceptin]], a [[monoclonal antibody]] for HER2 metastatic breast cancer<ref name=curetoday/>
* 1998 {{spaced ndash}} US FDA approves [[herceptin]], a [[monoclonal antibody]] for HER2 metastatic breast cancer<ref name=curetoday/>
* 1998 {{spaced ndash}} US FDA approves [[cryoablation]] for the treatment of prostate cancer <ref>{{cite web |title = Center for Devices and Radiological Health U.S. Food and Drug Administration. | url=http://www.fda.gov/ohrms/dockets/ac/03/briefing/3973b1_summary.htm}}</ref>
* 1998 {{spaced ndash}} US FDA approves [[cryoablation]] for the treatment of prostate cancer <ref>{{cite web |title = Center for Devices and Radiological Health U.S. Food and Drug Administration. | url=http://www.fda.gov/ohrms/dockets/ac/03/briefing/3973b1_summary.htm}}</ref>
* 1998 {{spaced ndash}} US FDA approves Camptothecin-analogue [[irinotecan]] for chemotherapy of cancer<ref>FDA Review Letter http://www.accessdata.fda.gov/drugsatfda_docs/appletter/1998/20571s8ltr.pdf</ref>
* 1998 {{spaced ndash}} US FDA approves Camptothecin-analogue [[irinotecan]] for chemotherapy of cancer<ref>FDA Review Letter http://www.accessdata.fda.gov/drugsatfda_docs/appletter/1998/20571s8ltr.pdf</ref>
* 1998 {{spaced ndash}} US FDA approves [[tamoxifen]] to reduce breast cancer risk in high-risk patients <ref name=curetoday/>
* 1998 {{spaced ndash}} US FDA approves [[tamoxifen]] to reduce breast cancer risk in high-risk patients <ref name=curetoday/>
* 1998 {{spaced ndash}} US FDA approves monoclonal antibody, [[ Trastuzumab]] for advanced HER-2 breast cancer <ref name=Milestones/>
===2000s===
===2000s===
* 2002 {{spaced ndash}} US FDA approves [[imatinib]] <ref name=curetoday/>
* 2002 {{spaced ndash}} US FDA approves [[imatinib]] <ref name=curetoday/>
* 2002 {{spaced ndash}} Chinese FDA approves [[Gendicine]], [[gene therapy]] for cancer <ref name=curetoday/><ref name=Gend>{{cite journal|author=|title=China approves first gene therapy|journal=Nature Biotechnology|year=2004|volume=22|number=|pages=3–4|pmid=14704685|url=http://www.nature.com/nbt/journal/v22/n1/full/nbt0104-3.html|doi=10.1038/nbt0104-3}}</ref>
* 2001 {{spaced ndash}} UK NICE approves [[taxol]] for chemotherapy of breast, ovarian, and non-small cell lung cancers <ref>{{cite web|url=http://www.bnf.org/bnf/bnf/current/21850.htm|title=British National Formulary}}</ref>
* 2001 {{spaced ndash}} UK NICE approves [[taxol]] for chemotherapy of breast, ovarian, and non-small cell lung cancers <ref>{{cite web|url=http://www.bnf.org/bnf/bnf/current/21850.htm|title=British National Formulary}}</ref>
* 2003 {{spaced ndash}} American Dr. Peter Littrup starts to treat early and metastatic [[ breast cancer]] with [[ cryoablation ]] <ref>According to Littrup et al., who performed cryoablation of breast tumors in clinical stages I-IV with a multi-probe freeze approach, isotherms within cryozones can be accurately controlled and such cryoablation enables the destruction of much bigger lesions, up to 7 cm in diameter (15){{cite journal | year = 2014 |title = Cryosurgery in the treatment of women with breast cancer. | url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115762/}}</ref>
* 2003 {{spaced ndash}} American Dr. Peter Littrup starts to treat early and metastatic [[ breast cancer]] with [[ cryoablation ]] <ref name=PMC4115762>According to Littrup et al., who performed cryoablation of breast tumors in clinical stages I-IV with a multi-probe freeze approach, isotherms within cryozones can be accurately controlled and such cryoablation enables the destruction of much bigger lesions, up to 7 cm in diameter (15){{cite journal | year = 2014 |title = Cryosurgery in the treatment of women with breast cancer. | url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115762/}}</ref>
* 2004 {{spaced ndash}} [[ bevacizumab ]], the first approved drug to [[anti-angiogenic|inhibit blood vessel]] formation by tumours, is licensed <ref name=raconteur/>
* 2004 {{spaced ndash}} [[ bevacizumab ]], the first approved drug to [[anti-angiogenic|inhibit blood vessel]] formation by tumours, is licensed <ref name=raconteur/>
* 2005 {{spaced ndash}} US FDA approves [[taxol]] for chemotherapy of breast, pancreatic, and non-small cell lung cancers<ref>{{Cite web|url = http://www.cancer.org/treatment/treatmentsideeffects//guidetocancerdrugs/paclitaxel-protein-bound-suspension|title = Paclitaxel, Protein-Bound Suspension|date = January 6, 2015|accessdate = January 24, 2015|website = Paclitaxel, Protein-Bound Suspension|publisher = Cancer.Org}}</ref>
* 2005 {{spaced ndash}} US FDA approves [[taxol]] for chemotherapy of breast, pancreatic, and non-small cell lung cancers<ref>{{Cite web|url = http://www.cancer.org/treatment/treatmentsideeffects//guidetocancerdrugs/paclitaxel-protein-bound-suspension|title = Paclitaxel, Protein-Bound Suspension|date = January 6, 2015|accessdate = January 24, 2015|website = Paclitaxel, Protein-Bound Suspension|publisher = Cancer.Org}}</ref>
Line 68: Line 82:
* 2007 {{spaced ndash}} US FDA approves [[sorafenib]] <ref name=curetoday/>
* 2007 {{spaced ndash}} US FDA approves [[sorafenib]] <ref name=curetoday/>
* 2007 {{spaced ndash}} US FDA approves [[camptothecin]]-analogue [[topotecan]] for chemotherapy of cancer<ref>{{Cite web|url = http://www.cancer.org/treatment/treatmentsideeffects//guidetocancerdrugs/paclitaxel-protein-bound-suspension|title = Paclitaxel, Protein-Bound Suspension|date = January 6, 2015|accessdate = January 24, 2015|website = Paclitaxel, Protein-Bound Suspension|publisher = Cancer.Org}}</ref>
* 2007 {{spaced ndash}} US FDA approves [[camptothecin]]-analogue [[topotecan]] for chemotherapy of cancer<ref>{{Cite web|url = http://www.cancer.org/treatment/treatmentsideeffects//guidetocancerdrugs/paclitaxel-protein-bound-suspension|title = Paclitaxel, Protein-Bound Suspension|date = January 6, 2015|accessdate = January 24, 2015|website = Paclitaxel, Protein-Bound Suspension|publisher = Cancer.Org}}</ref>
* 2010 {{spaced ndash}} US FDA approves immunotherapy, [[sipuleucel-T]] dendritic cell vaccine for advanced prostate cancer <ref name=Milestones/>
* 2011 {{spaced ndash}} US FDA approves monoclonal antibody, [[ Ipilimumab]] for advanced melanoma <ref name=Milestones/>
* 2015 {{spaced ndash}} US FDA approves anti-CDK4/6, [[Palbociclib]] for advanced breast cancer <ref name=Milestones/>


== External links ==
== External links ==
* [[https://books.google.com/books?id=iDNy0XxGqT8C|The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs]]
* [https://books.google.com/books?id=kfYeQSgWSwEC| The Rise And Fall Of Modern Medicine]
* [[https://books.google.ca/books?id=mtjgBwAAQBAJ|Chemotherapy]]
* [https://books.google.com/books?id=iDNy0XxGqT8C| The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs]
* [https://books.google.com/books?id=mtjgBwAAQBAJ| Chemotherapy]
* [https://www.cancer.gov/research/progress/discovery/methotrexate| Treatment of Solid Tumor Cancers with the Chemotherapy Drug Methotrexate]


== See also ==
== See also ==

Revision as of 20:55, 24 October 2016

This is a historical timeline of the development and progress of cancer treatments, which includes time of discovery and approval of the treatments.

Ancient Era

Cancer was traditionally treated with surgery and herbal therapies throughout history.

  • 1,500 BC  – Ancient Egyptians detail cauterization of breast tumors for treatment of the disease. [1]
  • 2 AD  – Ancient Greeks describe surgical treatment of cancer. [2] [3]

Modern Era

1800s

  • 1820s  – British Dr. James Arnott, “the father of modern cryosurgery”, starts to use cryotherapy to freeze tumors in the treatment of breast and uterine cancers[4]
  • 1866  – French Dr. Victor Despeignes, “the father of radiation therapy”, starts to use Xrays to treat cancer [5]
  • 1880s  – American Dr. Halsted develops radical mastectomy for breast cancer[3]
  • 1890s  – German Dr. Westermark used localized hyperthermia to produce tumor regression in patients
  • 1891  – American Dr. William B. Coley, “the father of immunotherapy”, starts to treat cancer patients by injecting them with streptococcal organisms, containing immunostimulatory CpG motifs [6][7]
  • 1896  – American Dr. Grubbe starts to treat breast cancer patients with X-rays[3]

1900s

2000s

External links

See also

References

  1. ^ "History of cancer treatment".
  2. ^ "The History of Cancer".
  3. ^ a b c d e f g h i j k l m "History of cancer treatment".
  4. ^ History of Cryosurgery. 2008.
  5. ^ "The physician who first applied radiotherapy, Victor Despeignes, on 1896". {{cite journal}}: Cite journal requires |journal= (help)
  6. ^ Krieg, AM; Yi, AK; Matson, S; Waldschmidt, TJ; Bishop, GA; Teasdale, R; Koretzky, GA; Klinman, DM (1995). "CpG motifs in bacterial DNA trigger direct B-cell activation". Nature. 374 (6522): 546–9. doi:10.1038/374546a0. PMID 7700380.
  7. ^ "The Toxins of William B. Coley and the Treatment of Cancer". {{cite journal}}: Cite journal requires |journal= (help)
  8. ^ a b c d e f g h i j k l m "Timeline: Milestones in Cancer Treatment".
  9. ^ "First Use of Intravenous Chemotherapy Cancer Treatment: Rectifying the Record". {{cite journal}}: Cite journal requires |journal= (help)
  10. ^ a b c d e f g {cite web|title=Milestones in Cancer Research and Discovery|url=https://www.cancer.gov/research/progress/250-years-milestones}}
  11. ^ "Clinical virotherapy: four historically significant clinical trials".
  12. ^ Huebner, RJ; Rowe, WP; Schatten, WE; Smith, RR; Thomas, LB (Nov–Dec 1956). "Studies on the use of viruses in the treatment of carcinoma of the cervix". Cancer. 9 (6): 1211–8. doi:10.1002/1097-0142(195611/12)9:6<1211::AID-CNCR2820090624>3.0.CO;2-7. PMID 13383455.
  13. ^ Fujiwara, A.; Hoshino, T.; Westley, J. W. (1985). "Anthracycline Antibiotics". Critical Reviews in Biotechnology. 3 (2): 133. doi:10.3109/07388558509150782.
  14. ^ A Master of Science History: Essays in Honor of Charles Coulston Gillispie.
  15. ^ Emadi A, Jones RJ, Brodsky RA (2009). "Cyclophosphamide and cancer: golden anniversary". Nat Rev Clin Oncol. 6 (11): 638–47. doi:10.1038/nrclinonc.2009.146. PMID 19786984.
  16. ^ Goldman (1966). "A review: Applications of the laser beam in cancer biology". {{cite journal}}: Cite journal requires |journal= (help)
  17. ^ a b Ravina, Enrique (2011). The evolution of drug discovery : from traditional medicines to modern drugs (1. Aufl. ed.). Weinheim: Wiley-VCH. pp. 157–159. ISBN 9783527326693.
  18. ^ a b c d "A History of Cancer Chemotherapy".
  19. ^ Muceniece A.J., Bumbieris J.V. 1982. Transplantation antigens and their changes in carcinogenesis and viral infection. In: Virusnyi onkoliz i iskusstvennaya geterogenizatsiya opukholei (Viral Oncolysis and Artificial Heterogenization of Tumors). Riga, pp. 217–234.
  20. ^ the stem bark of Mappia foetida , a tree native to India, has proved to be another source significant for the isolation of camptothecin.TR Govindachari and N. Viswnathan, Phytochemistry,11(12), 3529-31 (1972)). Efferth T, Fu YJ, Zu YG, Schwarz G, Konkimalla VS, Wink M (2007). "Molecular target-guided tumor therapy with natural products derived from traditional Chinese medicine". Current medicinal chemistry. 14 (19): 2024–32. doi:10.2174/092986707781368441.
  21. ^ Tanaka (1982). "Immunological aspects of cryosurgery in general surgery". Cryobiology.
  22. ^ Richard J. Ablin, PhD (1998). "The Use of Cryosurgery for Breast Cancer". Arch Surg.
  23. ^ a b According to Littrup et al., who performed cryoablation of breast tumors in clinical stages I-IV with a multi-probe freeze approach, isotherms within cryozones can be accurately controlled and such cryoablation enables the destruction of much bigger lesions, up to 7 cm in diameter (15)"Cryosurgery in the treatment of women with breast cancer". 2014. {{cite journal}}: Cite journal requires |journal= (help)
  24. ^ Tamoxifen: Pioneering Medicine in Breast Cancer.
  25. ^ Tamoxifen was born into a world of indifference in the '60s, when the focus of the research was on contraception. It grew up in the 70s, in a world where chemotherapy was king and hormonal therapies were perceived as non-starters in the quest to cure cancer.Tamoxifen: a personal retrospective (PDF).
  26. ^ "Center for Devices and Radiological Health U.S. Food and Drug Administration".
  27. ^ Huang, Z (2006). "Photodynamic therapy in China: Over 25 years of unique clinical experience: Part One—History and domestic photosensitizers". Photodiagnosis and Photodynamic Therapy. 3: 3–10. doi:10.1016/S1572-1000(06)00009-3.
    Xu, DY (2007). "Research and development of photodynamic therapy photosensitizers in China". Photodiagnosis and Photodynamic Therapy. 4: 13–25. doi:10.1016/j.pdpdt.2006.09.003.
  28. ^ "The Story of Gleevec".
  29. ^ "Centre of laser medicine — Historical Aspects of Photodynamic Therapy Development". Retrieved 2011-08-05.
  30. ^ In 1997, a patient with osteosarcoma was first successfully treated with ultrasound imaging-guided HIFU in Chongqing, China. Over the last decade, thousands of patients with uterine fibroids, liver cancer, breast cancer, pancreatic cancer, bone tumors, and renal cancer have been treated with ultrasound imaging-guided HIFU. Based on several research groups’ reports, as well as our ten-year clinical experience, we conclude that this technique is safe and effective in treating human solid tumors."High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience". 2010. {{cite journal}}: Cite journal requires |journal= (help)
  31. ^ History of Cryosurgery. 1997.
  32. ^ "FAQ".
  33. ^ "Center for Devices and Radiological Health U.S. Food and Drug Administration".
  34. ^ FDA Review Letter http://www.accessdata.fda.gov/drugsatfda_docs/appletter/1998/20571s8ltr.pdf
  35. ^ "China approves first gene therapy". Nature Biotechnology. 22: 3–4. 2004. doi:10.1038/nbt0104-3. PMID 14704685.
  36. ^ "British National Formulary".
  37. ^ "Paclitaxel, Protein-Bound Suspension". Paclitaxel, Protein-Bound Suspension. Cancer.Org. January 6, 2015. Retrieved January 24, 2015.
  38. ^ "Paclitaxel, Protein-Bound Suspension". Paclitaxel, Protein-Bound Suspension. Cancer.Org. January 6, 2015. Retrieved January 24, 2015.
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