List of fibrinogen disorders: Difference between revisions
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Fibrinogen disorders are set of hereditary or acquired abnormalities in the quantity and/or quality of circulating [[fibrinogen]]s. The disorders may lead to pathological bleeding and/or [[blood clotting]] or the deposition of fibrinogen or portions thereof in the vasculature or tissues. These disorders include: |
Fibrinogen disorders are set of hereditary or acquired abnormalities in the quantity and/or quality of circulating [[fibrinogen]]s. The disorders may lead to pathological bleeding and/or [[blood clotting]] or the deposition of fibrinogen or portions thereof in the vasculature or tissues. These disorders include: |
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* [[Congenital afibrinogenemia]], an inherited blood disorder in which blood does not clot normally due to the lack of fibrinogen; the disorder causes excessive bleeding episodes. |
* [[Congenital afibrinogenemia]], an inherited blood disorder in which blood does not clot normally due to the lack of fibrinogen; the disorder causes excessive bleeding episodes.<ref name="pmid27019462">{{cite journal | vauthors = Casini A, de Moerloose P, Neerman-Arbez M | title = Clinical Features and Management of Congenital Fibrinogen Deficiencies | journal = Seminars in Thrombosis and Hemostasis | volume = 42 | issue = 4 | pages = 366–74 | year = 2016 | pmid = 27019462 | doi = 10.1055/s-0036-1571339 | url = }}</ref> |
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* [[Factor I Deficiency|Congenital hypofibrinogenemia]], an inherited disorder in which blood may clot normally due to reduced levels of fibrinogen; the disorder may or may not cause excessive bleeding episodes. |
* [[Factor I Deficiency|Congenital hypofibrinogenemia]], an inherited disorder in which blood may clot normally due to reduced levels of fibrinogen; the disorder may or may not cause excessive bleeding episodes.<ref name="pmid27019462">{{cite journal | vauthors = Casini A, de Moerloose P, Neerman-Arbez M | title = Clinical Features and Management of Congenital Fibrinogen Deficiencies | journal = Seminars in Thrombosis and Hemostasis | volume = 42 | issue = 4 | pages = 366–74 | year = 2016 | pmid = 27019462 | doi = 10.1055/s-0036-1571339 | url = }}</ref> |
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* [[Dysfibrinogenemia|Congenital dysfibrinogenemia]], an inherited disorder in which normal levels of fibrinogen composed at least in part of a dysfunctional fibrinogen may cause pathological episodes of bleeding or blood clotting. |
* [[Dysfibrinogenemia|Congenital dysfibrinogenemia]], an inherited disorder in which normal levels of fibrinogen composed at least in part of a dysfunctional fibrinogen may cause pathological episodes of bleeding or blood clotting.<ref name="pmid25816717">{{cite journal | vauthors = Casini A, Neerman-Arbez M, Ariëns RA, de Moerloose P | title = Dysfibrinogenemia: from molecular anomalies to clinical manifestations and management | journal = Journal of Thrombosis and Haemostasis : JTH | volume = 13 | issue = 6 | pages = 909–19 | year = 2015 | pmid = 25816717 | doi = 10.1111/jth.12916 | url = }}</ref> |
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* [[Dysfibrinogenemia#Acquired dysfibrinogenemia|Acquired dysfibrinogenemia]], an inherited disorder in which normal levels of fibrinogen composed at least in part of a dysfunctional fibrinogen may cause pathological episodes of bleeding or blood clotting. |
* [[Dysfibrinogenemia#Acquired dysfibrinogenemia|Acquired dysfibrinogenemia]], an inherited disorder in which normal levels of fibrinogen composed at least in part of a dysfunctional fibrinogen may cause pathological episodes of bleeding or blood clotting.<ref name="pmid27713652">{{cite journal | vauthors = Besser MW, MacDonald SG | title = Acquired hypofibrinogenemia: current perspectives | journal = Journal of Blood Medicine | volume = 7 | issue = | pages = 217–225 | year = 2016 | pmid = 27713652 | pmc = 5045218 | doi = 10.2147/JBM.S90693 | url = }}</ref> |
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* [[Hypodysfibrinogenemia|Congenital hypodysfibrinogenemia]], an inherited disorder in which '''low''' levels of fibrinogen composed at least in part of a dysfunctional fibrinogen may cause pathological episodes of bleeding or blood clotting. |
* [[Hypodysfibrinogenemia|Congenital hypodysfibrinogenemia]], an inherited disorder in which '''low''' levels of fibrinogen composed at least in part of a dysfunctional fibrinogen may cause pathological episodes of bleeding or blood clotting.<ref name="pmid28211264">{{cite journal | vauthors = Casini A, Brungs T, Lavenu-Bombled C, Vilar R, Neerman-Arbez M, de Moerloose P | title = Genetics, diagnosis and clinical features of congenital hypodysfibrinogenemia: a systematic literature review and report of a novel mutation | journal = Journal of Thrombosis and Haemostasis : JTH | volume = 15 | issue = 5 | pages = 876–888 | year = 2017 | pmid = 28211264 | doi = 10.1111/jth.13655 | url = }}</ref> |
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* [[Dysfibrinogenemia#Hereditary fibrinogen Aα-Chain amyloidosis|Hereditary fibrinogen Aα-Chain amyloidosis]], an inherited disorder in which the [[fibrinogen alpha chain]] deposits in the kidney to cause renal [[amyloidosis]] and consequential kidney failure. |
* [[Dysfibrinogenemia#Hereditary fibrinogen Aα-Chain amyloidosis|Hereditary fibrinogen Aα-Chain amyloidosis]], an inherited disorder in which the [[fibrinogen alpha chain]] deposits in the kidney to cause renal [[amyloidosis]] and consequential kidney failure.<ref name="pmid19073821">{{cite journal | vauthors = Gillmore JD, Lachmann HJ, Rowczenio D, Gilbertson JA, Zeng CH, Liu ZH, Li LS, Wechalekar A, Hawkins PN | title = Diagnosis, pathogenesis, treatment, and prognosis of hereditary fibrinogen A alpha-chain amyloidosis | journal = Journal of the American Society of Nephrology : JASN | volume = 20 | issue = 2 | pages = 444–51 | year = 2009 | pmid = 19073821 | pmc = 2637055 | doi = 10.1681/ASN.2008060614 | url = }}</ref> |
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* [[Cryofibrinogenemia]], an acquired disorder in which fibrinogen precipitates at cold temperatures and may lead to the intravascular precipitation of fibrinogen, [[fibrin]], and other circulating proteins and thereby cause the [[infarction]] of various tissues and bodily extremities. |
* [[Cryofibrinogenemia]], an acquired disorder in which fibrinogen precipitates at cold temperatures and may lead to the intravascular precipitation of fibrinogen, [[fibrin]], and other circulating proteins and thereby cause the [[infarction]] of various tissues and bodily extremities.<ref name="pmid28550239">{{cite journal | vauthors = Caimi G, Canino B, Lo Presti R, Urso C, Hopps E | title = Clinical conditions responsible for hyperviscosity and skin ulcers complications | journal = Clinical Hemorheology and Microcirculation | volume = | issue = | pages = | year = 2017 | pmid = 28550239 | doi = 10.3233/CH-160218 | url = }}</ref> |
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== References == |
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Revision as of 13:16, 2 September 2017
Fibrinogen disorders are set of hereditary or acquired abnormalities in the quantity and/or quality of circulating fibrinogens. The disorders may lead to pathological bleeding and/or blood clotting or the deposition of fibrinogen or portions thereof in the vasculature or tissues. These disorders include:
- Congenital afibrinogenemia, an inherited blood disorder in which blood does not clot normally due to the lack of fibrinogen; the disorder causes excessive bleeding episodes.[1]
- Congenital hypofibrinogenemia, an inherited disorder in which blood may clot normally due to reduced levels of fibrinogen; the disorder may or may not cause excessive bleeding episodes.[1]
- Congenital dysfibrinogenemia, an inherited disorder in which normal levels of fibrinogen composed at least in part of a dysfunctional fibrinogen may cause pathological episodes of bleeding or blood clotting.[2]
- Acquired dysfibrinogenemia, an inherited disorder in which normal levels of fibrinogen composed at least in part of a dysfunctional fibrinogen may cause pathological episodes of bleeding or blood clotting.[3]
- Congenital hypodysfibrinogenemia, an inherited disorder in which low levels of fibrinogen composed at least in part of a dysfunctional fibrinogen may cause pathological episodes of bleeding or blood clotting.[4]
- Hereditary fibrinogen Aα-Chain amyloidosis, an inherited disorder in which the fibrinogen alpha chain deposits in the kidney to cause renal amyloidosis and consequential kidney failure.[5]
- Cryofibrinogenemia, an acquired disorder in which fibrinogen precipitates at cold temperatures and may lead to the intravascular precipitation of fibrinogen, fibrin, and other circulating proteins and thereby cause the infarction of various tissues and bodily extremities.[6]
References
- ^ a b Casini A, de Moerloose P, Neerman-Arbez M (2016). "Clinical Features and Management of Congenital Fibrinogen Deficiencies". Seminars in Thrombosis and Hemostasis. 42 (4): 366–74. doi:10.1055/s-0036-1571339. PMID 27019462.
- ^ Casini A, Neerman-Arbez M, Ariëns RA, de Moerloose P (2015). "Dysfibrinogenemia: from molecular anomalies to clinical manifestations and management". Journal of Thrombosis and Haemostasis : JTH. 13 (6): 909–19. doi:10.1111/jth.12916. PMID 25816717.
- ^ Besser MW, MacDonald SG (2016). "Acquired hypofibrinogenemia: current perspectives". Journal of Blood Medicine. 7: 217–225. doi:10.2147/JBM.S90693. PMC 5045218. PMID 27713652.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Casini A, Brungs T, Lavenu-Bombled C, Vilar R, Neerman-Arbez M, de Moerloose P (2017). "Genetics, diagnosis and clinical features of congenital hypodysfibrinogenemia: a systematic literature review and report of a novel mutation". Journal of Thrombosis and Haemostasis : JTH. 15 (5): 876–888. doi:10.1111/jth.13655. PMID 28211264.
- ^ Gillmore JD, Lachmann HJ, Rowczenio D, Gilbertson JA, Zeng CH, Liu ZH, Li LS, Wechalekar A, Hawkins PN (2009). "Diagnosis, pathogenesis, treatment, and prognosis of hereditary fibrinogen A alpha-chain amyloidosis". Journal of the American Society of Nephrology : JASN. 20 (2): 444–51. doi:10.1681/ASN.2008060614. PMC 2637055. PMID 19073821.
- ^ Caimi G, Canino B, Lo Presti R, Urso C, Hopps E (2017). "Clinical conditions responsible for hyperviscosity and skin ulcers complications". Clinical Hemorheology and Microcirculation. doi:10.3233/CH-160218. PMID 28550239.