Dermal equivalent: Difference between revisions
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The '''dermal equivalent''' is an [[in vitro]] model of the [[dermis|dermal layer]] of skin. It is constructed by seeding dermal [[fibroblast]]s into a [[collagen]] gel. This gel may then be allowed to contract as a model of [[wound contraction]]. This [[collagen gel contraction assay]] may be used to screen for treatments which promote or inhibit contraction and thus affect the development of a [[scar]]. Other cell types may be incorporated into the dermal equivalent to increase the complexity of the model. For example, [[keratinocytes]] may be seeded on the surface to create a [[skin equivalent]], or [[macrophages]] may be incorporated to model the inflammatory phase of [[wound healing]].<ref> |
The '''dermal equivalent''' is an [[in vitro]] model of the [[dermis|dermal layer]] of skin. It is constructed by seeding dermal [[fibroblast]]s into a [[collagen]] gel. This gel may then be allowed to contract as a model of [[wound contraction]]. This [[collagen gel contraction assay]] may be used to screen for treatments which promote or inhibit contraction and thus affect the development of a [[scar]]. Other cell types may be incorporated into the dermal equivalent to increase the complexity of the model. For example, [[keratinocytes]] may be seeded on the surface to create a [[skin equivalent]], or [[macrophages]] may be incorporated to model the inflammatory phase of [[wound healing]].<ref>{{cite journal |doi=10.1023/B:IFLA.0000049045.41784.59 }}</ref> |
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==References== |
==References== |
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Revision as of 13:31, 4 August 2018
The dermal equivalent is an in vitro model of the dermal layer of skin. It is constructed by seeding dermal fibroblasts into a collagen gel. This gel may then be allowed to contract as a model of wound contraction. This collagen gel contraction assay may be used to screen for treatments which promote or inhibit contraction and thus affect the development of a scar. Other cell types may be incorporated into the dermal equivalent to increase the complexity of the model. For example, keratinocytes may be seeded on the surface to create a skin equivalent, or macrophages may be incorporated to model the inflammatory phase of wound healing.[1]
References
- ^ . doi:10.1023/B:IFLA.0000049045.41784.59.
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