Monalazone: Difference between revisions

Monalazone
Clinical data
Other names	p-(Chlorosulfamoyl)benzoic acid
Routes of; administration	Vaginal
Drug class	Disinfectant
Identifiers
	IUPAC name 4-(chlorosulfamoyl)benzoic acid;
CAS Number	106145-03-3 ; 61477-95-0 (disodium);
PubChem CID	68809;
ChemSpider	62045;
UNII	2UP9F49N8H;
ChEMBL	ChEMBL2110958;
CompTox Dashboard (EPA)	DTXSID70147532 ;
Chemical and physical data
Formula	C7H6ClNO4S
Molar mass	235.638 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC(=CC=C1C(=O)O)S(=O)(=O)NCl;
	InChI InChI=1S/C7H6ClNO4S/c8-9-14(12,13)6-3-1-5(2-4-6)7(10)11/h1-4,9H,(H,10,11); Key:WGHSWNHOFPGMKJ-UHFFFAOYSA-N;

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Revision as of 08:54, 11 June 2019

Monalazone, used as monalazone disodium (INNTooltip International Nonproprietary Name; the disodium salt) and sold under the brand names Naclobenz-Natrium, Spergisin, Speton, is a vaginal disinfectant or antiseptic and spermicidal contraceptive.^[1]^[2]^[3]^[4] It is a sulphonylbenzoic acid derivative and is closely related structurally to halazone.^[2] The compound was synthesized in 1937.^[1] A vaginal tablet combination of 0.125 mg estradiol benzoate and 10 mg monalazone was previously marketed under the brand name Malun 25.^[5]^[3]

^ ^a ^b J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 834–. ISBN 978-1-4757-2085-3.
^ ^a ^b I.K. Morton; Judith M. Hall (31 October 1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 185–. ISBN 978-0-7514-0499-9.
^ ^a ^b William Martindale; Royal Pharmaceutical Society of Great Britain. Dept. of Pharmaceutical Sciences (1993). The Extra Pharmacopoeia. Pharmaceutical Press. ISBN 978-0-85369-300-0. Monalazone disodium is an antiseptic closely related structurally to halazone (see p.796) and is used as a vaginal disinfectant and spermicide. Proprietary Names Malun N. Sperlisin. Multi-ingredient preparations. Malun.
^ RÖMPP Lexikon Chemie, 10. Auflage, 1996-1999: Band 4: M - Pk. Thieme. 16 July 2014. pp. 2000–2001. ISBN 978-3-13-200031-5.
^ Freimut A. Leidenberger (17 April 2013). Klinische Endokrinologie für Frauenärzte. Springer-Verlag. pp. 527–. ISBN 978-3-662-08110-5.

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