Estradiol benzoate

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See also: estradiol and estrogen
Estradiol benzoate
Estradiol benzoate.svg
Systematic (IUPAC) name
(17β)-17-hydroxyestra-1,3,5(10)-trien-3-yl benzoate
Clinical data
Legal status
  • Prescription only
Routes IM
Identifiers
CAS number 50-50-0
ATC code None
PubChem CID 222757
ChemSpider 193412
ChEBI CHEBI:77006
Synonyms 17β-Estradiol-3-benzoate
Chemical data
Formula C25H28O3 
Mol. mass 376.488 g/mol

Estradiol benzoate (INN; brand names Agofollin, Diffolisterol, Progynon-B, many others), or oestradiol benzoate (BAN), is a synthetic ester, specifically the 3-benzoyl ester, of the natural estrogen, estradiol.[1][2] It was the first form of estrogen to be marketed, patented by Schering-Kahlbaun in 1936 in an oil preparation for injectable use and introduced later that year as Progynon-B.[3][4] Though it is still in widespread use today, it has been mostly superseded by newer forms of estradiol with improved pharmacokinetics in which require less frequent administration such as estradiol cypionate and estradiol valerate.[5]

See also[edit]

References[edit]

  1. ^ A. D. Roberts (1991). Dictionary of Steroids: Chemical Data, Structures, and Bibliographies. CRC Press. p. 414. ISBN 978-0-412-27060-4. Retrieved 20 May 2012. 
  2. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 406. ISBN 978-3-88763-075-1. Retrieved 20 May 2012. 
  3. ^ Enrique Raviña; Hugo Kubinyi (16 May 2011). The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs. John Wiley & Sons. p. 175. ISBN 978-3-527-32669-3. Retrieved 20 May 2012. 
  4. ^ Folley SJ (December 1936). "The effect of oestrogenic hormones on lactation and on the phosphatase of the blood and milk of the lactating cow". The Biochemical Journal 30 (12): 2262–72. PMC 1263335. PMID 16746289. 
  5. ^ Oriowo MA, Landgren BM, Stenström B, Diczfalusy E (April 1980). "A comparison of the pharmacokinetic properties of three estradiol esters". Contraception 21 (4): 415–24. doi:10.1016/s0010-7824(80)80018-7. PMID 7389356.