Cheilanthifoline: Difference between revisions
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(S)-Cheilanthifoline is a [[benzylisoquinoline]] [[alkaloid]] (BIA) isolated from ''[[Corydalis]] dubia,'' which is used in Bhutanese traditional medicine as a [[Antipyretic|febrifuge]] as well for other conditions.<ref>{{cite journal|pmid=22796506|year=2012|last1=Wangchuk|first1=P|last2=Keller|first2=PA|last3=Pyne|first3=SG|last4=Willis|first4=AC|last5=Kamchonwongpaisan|first5=S|title=Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia|volume=143|issue=1|pages=310–3|doi=10.1016/j.jep.2012.06.037|journal=Journal of Ethnopharmacology}}</ref> ''(S)-''Cheilanthifoline is metabolically derived from ''(S)-''[[reticuline]], a pivotal intermediate in the biosynthesis of numerous BIAs. ''(S)-''Cheilanthifoline is the immediate precursor of the BIA ''(S)-''stylopine (''([[(S)-stylopine synthase|S)-]]''[[(S)-stylopine synthase|stylopine synthase]]/CYP719A20), which is the precursor for the alkaloids [[protopine]] and sanguinarine.<ref>{{Cite journal|last=Hagel|first=Jillian|last2=Morris|first2=Jeremy S|last3=Lee|first3=Eun-Jeong|last4=Desgagne-Penix|first4=Isabel|last5=Bross|first5=Crystal D|last6=Chang|first6=Limei|last7=Chen|first7=Xue|last8=Farrow|first8=Scott C|last9=Zhang|first9=Te|date=2015|title=Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants|url=|journal=BMC Plant Biology|volume=15|pages=227|doi=10.1186/s12870-015-0596-0|pmid=26384972|via=}}</ref> |
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==References== |
==References== |
Revision as of 18:28, 18 July 2019
Names | |
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Other names
(S)-Cheilanthifoline
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Identifiers | |
3D model (JSmol)
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ChemSpider |
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PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C19H19NO4 | |
Molar mass | 325.364 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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(S)-Cheilanthifoline is a benzylisoquinoline alkaloid (BIA) isolated from Corydalis dubia, which is used in Bhutanese traditional medicine as a febrifuge as well for other conditions.[1] (S)-Cheilanthifoline is metabolically derived from (S)-reticuline, a pivotal intermediate in the biosynthesis of numerous BIAs. (S)-Cheilanthifoline is the immediate precursor of the BIA (S)-stylopine ((S)-stylopine synthase/CYP719A20), which is the precursor for the alkaloids protopine and sanguinarine.[2]
References
- ^ Wangchuk, P; Keller, PA; Pyne, SG; Willis, AC; Kamchonwongpaisan, S (2012). "Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia". Journal of Ethnopharmacology. 143 (1): 310–3. doi:10.1016/j.jep.2012.06.037. PMID 22796506.
- ^ Hagel, Jillian; Morris, Jeremy S; Lee, Eun-Jeong; Desgagne-Penix, Isabel; Bross, Crystal D; Chang, Limei; Chen, Xue; Farrow, Scott C; Zhang, Te (2015). "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. doi:10.1186/s12870-015-0596-0. PMID 26384972.
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: CS1 maint: unflagged free DOI (link)