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#REDIRECT [[Chromosome 21 open reading frame 91]] |
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'''EURL''' is a [[Structural gene|structural protein gene]] that is encoded within the [[human chromosome 21]].<ref name = "Li_2016">{{cite journal | vauthors = Li SS, Qu Z, Haas M, Ngo L, Heo YJ, Kang HJ, Britto JM, Cullen HD, Vanyai HK, Tan SS, Chan-Ling T, Gunnersen JM, Heng JI | display-authors = 6 | title = The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome | journal = Scientific Reports | volume = 6 | pages = 29514 | date = July 2016 | pmid = 27404227 | pmc = 4941730 | doi = 10.1038/srep29514 | bibcode = 2016NatSR...629514L }}</ref><ref>{{cite journal | vauthors = Kirk IK, Weinhold N, Belling K, Skakkebæk NE, Jensen TS, Leffers H, Juul A, Brunak S | display-authors = 6 | title = Chromosome-wise Protein Interaction Patterns and Their Impact on Functional Implications of Large-Scale Genomic Aberrations | language = English | journal = Cell Systems | volume = 4 | issue = 3 | pages = 357–364.e3 | date = March 2017 | pmid = 28215527 | doi = 10.1016/j.cels.2017.01.001 | url = https://www.cell.com/cell-systems/abstract/S2405-4712(17)30001-7 | access-date = 2019-04-15 }}</ref> It stands for gene Expressed in Undifferentiated Retina and Lens and was first found in [[chick embryo]]s. It is also known as C21orf 91 (Chromosome 21 open reading frame 91)<ref>{{cite web |url=https://www.proteinatlas.org/ENSG00000154642-C21orf91/tissue |access-date=14 April 2019 |title=C21orf91}}</ref>. This gene produces many molecules; among them is a protein that influences neural development. This protein-coding region helps to code for neural development in humans and is strongly associated with neural [[progenitor cells]] as well as neurons associated with the [[cerebral cortex]] of the brain.<ref name = "Li_2016" /> |
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Thus, being on chromosome 21, defects linked to this gene are heavily correlated to [[Down Syndrome]]. There are some knockout models regarding other genes involved in Down Syndrome, but there seems to be primary interest in a knockdown model for this specific gene. It is believed that because there is three codes of this gene rather than two, that the higher concentration of this molecule has the implications leading to Down Syndrome. Scientists are currently working on a hypothesis that the dosage of the EURL protein is directly correlated to neural development in the embryo and how an altered dosage leads to the neural deficits seen in Down Syndrome.<ref name = "Li_2016" /> |
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== References == |
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{{reflist}} |
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== External links == |
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* {{cite web |url=https://www.proteinatlas.org/ENSG00000154642-C21orf91/tissue |access-date=14 April 2019|title=Tissue expression of C21orf91 - Summary |work=the Human Protein Atlas}} |
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[[Category:Genes]] |
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Revision as of 14:39, 6 August 2019
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