SHC014-CoV: Difference between revisions
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'''SHC014-CoV''' is a [[Severe acute respiratory syndrome coronavirus|SARS]]-like [[coronavirus]] (SL-COV) which infects [[horseshoe bats]] (f. Rhinolophidae), first discovered in China in 2013.<ref>Ge |
'''SHC014-CoV''' is a [[Severe acute respiratory syndrome coronavirus|SARS]]-like [[coronavirus]] (SL-COV) which infects [[horseshoe bats]] (f. Rhinolophidae), first discovered in China in 2013.<ref name="Ge et al 2013">{{cite journal |last1=Ge |first1=Xing-Yi |last2=Li |first2=Jia-Lu |last3=Yang |first3=Xing-Lou |last4=Chmura |first4=Aleksei A. |last5=Zhu |first5=Guangjian |last6=Epstein |first6=Jonathan H. |last7=Mazet |first7=Jonna K. |last8=Hu |first8=Ben |last9=Zhang |first9=Wei |last10=Peng |first10=Cheng |last11=Zhang |first11=Yu-Ji |last12=Luo |first12=Chu-Ming |last13=Tan |first13=Bing |last14=Wang |first14=Ning |last15=Zhu |first15=Yan |last16=Crameri |first16=Gary |last17=Zhang |first17=Shu-Yi |last18=Wang |first18=Lin-Fa |last19=Daszak |first19=Peter |last20=Shi |first20=Zheng-Li |title=Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor |journal=Nature |date=30 October 2013 |volume=503 |issue=7477 |pages=535–538 |doi=10.1038/nature12711 }}</ref> |
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From April 2011 to September 2012, 117 anal swabs and fecal samples of bats were collected from a Rhinolophus sinicus bat colony in Kunming County (Yunnan Province in south-western China). 27 out of 117 samples (23%) contained seven different isolates of a SARS-like coronaviruses, among which were two previously unknown, called RsSHC014 and Rs3367. |
From April 2011 to September 2012, 117 anal swabs and fecal samples of bats were collected from a Rhinolophus sinicus bat colony in Kunming County (Yunnan Province in south-western China). 27 out of 117 samples (23%) contained seven different isolates of a SARS-like coronaviruses, among which were two previously unknown, called RsSHC014 and Rs3367.<ref name="Ge et al 2013"/> |
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In 2015, the [[University of North Carolina at Chapel Hill]] and the [[Wuhan Institute of Virology]] conducted research showing the virus could be made to infect the human [[HeLa]] cell line, through the use of [[reverse genetics]] to create a [[Chimera (virus)|chimeric]] virus consisting of a surface protein of SHC014 and the backbone of a SARS virus.<ref>Menachery |
In 2015, the [[University of North Carolina at Chapel Hill]] and the [[Wuhan Institute of Virology]] conducted research showing the virus could be made to infect the human [[HeLa]] cell line, through the use of [[reverse genetics]] to create a [[Chimera (virus)|chimeric]] virus consisting of a surface protein of SHC014 and the backbone of a SARS virus.<ref>{{cite journal |last1=Menachery |first1=Vineet D |last2=Yount |first2=Boyd L |last3=Debbink |first3=Kari |last4=Agnihothram |first4=Sudhakar |last5=Gralinski |first5=Lisa E |last6=Plante |first6=Jessica A |last7=Graham |first7=Rachel L |last8=Scobey |first8=Trevor |last9=Ge |first9=Xing-Yi |last10=Donaldson |first10=Eric F |last11=Randell |first11=Scott H |last12=Lanzavecchia |first12=Antonio |last13=Marasco |first13=Wayne A |last14=Shi |first14=Zhengli-Li |last15=Baric |first15=Ralph S |title=A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence |journal=Nature Medicine |date=9 November 2015 |volume=21 |issue=12 |pages=1508–1513 |doi=10.1038/nm.3985 }}</ref><ref>{{cite journal |last1=Butler |first1=Declan |title=Engineered bat virus stirs debate over risky research |journal=Nature |date=12 November 2015 |doi=10.1038/nature.2015.18787 }}</ref> The SL-SHC014-MA15 version of the virus, primarily engineered to infect mice, has been shown to differ 7% (over 5,000 nucleotides) from [[SARS-CoV-2]], the cause of a human [[2019–20 coronavirus pandemic|pandemic in 2019-2020]].<ref>{{cite journal |last1=Liu |first1=Shan-Lu |last2=Saif |first2=Linda J. |last3=Weiss |first3=Susan R. |last4=Su |first4=Lishan |title=No credible evidence supporting claims of the laboratory engineering of SARS-CoV-2 |journal=Emerging Microbes & Infections |date=26 February 2020 |volume=9 |issue=1 |pages=505–507 |doi=10.1080/22221751.2020.1733440 }}</ref> |
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==References== |
==References== |
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Revision as of 20:16, 24 April 2020
SHC014-CoV is a SARS-like coronavirus (SL-COV) which infects horseshoe bats (f. Rhinolophidae), first discovered in China in 2013.[1]
From April 2011 to September 2012, 117 anal swabs and fecal samples of bats were collected from a Rhinolophus sinicus bat colony in Kunming County (Yunnan Province in south-western China). 27 out of 117 samples (23%) contained seven different isolates of a SARS-like coronaviruses, among which were two previously unknown, called RsSHC014 and Rs3367.[1]
In 2015, the University of North Carolina at Chapel Hill and the Wuhan Institute of Virology conducted research showing the virus could be made to infect the human HeLa cell line, through the use of reverse genetics to create a chimeric virus consisting of a surface protein of SHC014 and the backbone of a SARS virus.[2][3] The SL-SHC014-MA15 version of the virus, primarily engineered to infect mice, has been shown to differ 7% (over 5,000 nucleotides) from SARS-CoV-2, the cause of a human pandemic in 2019-2020.[4]
References
- ^ a b Ge, Xing-Yi; Li, Jia-Lu; Yang, Xing-Lou; Chmura, Aleksei A.; Zhu, Guangjian; Epstein, Jonathan H.; Mazet, Jonna K.; Hu, Ben; Zhang, Wei; Peng, Cheng; Zhang, Yu-Ji; Luo, Chu-Ming; Tan, Bing; Wang, Ning; Zhu, Yan; Crameri, Gary; Zhang, Shu-Yi; Wang, Lin-Fa; Daszak, Peter; Shi, Zheng-Li (30 October 2013). "Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor". Nature. 503 (7477): 535–538. doi:10.1038/nature12711.
- ^ Menachery, Vineet D; Yount, Boyd L; Debbink, Kari; Agnihothram, Sudhakar; Gralinski, Lisa E; Plante, Jessica A; Graham, Rachel L; Scobey, Trevor; Ge, Xing-Yi; Donaldson, Eric F; Randell, Scott H; Lanzavecchia, Antonio; Marasco, Wayne A; Shi, Zhengli-Li; Baric, Ralph S (9 November 2015). "A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence". Nature Medicine. 21 (12): 1508–1513. doi:10.1038/nm.3985.
- ^ Butler, Declan (12 November 2015). "Engineered bat virus stirs debate over risky research". Nature. doi:10.1038/nature.2015.18787.
- ^ Liu, Shan-Lu; Saif, Linda J.; Weiss, Susan R.; Su, Lishan (26 February 2020). "No credible evidence supporting claims of the laboratory engineering of SARS-CoV-2". Emerging Microbes & Infections. 9 (1): 505–507. doi:10.1080/22221751.2020.1733440.
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