Marta Catellani: Difference between revisions
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Her research focuses on [[palladium]] as a catalyst for multistep organic reactions.<ref name=":0" /><ref name=":1" /> |
Her research focuses on [[palladium]] as a catalyst for multistep organic reactions.<ref name=":0" /><ref name=":1" /> |
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== The Catellani Reaction == |
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In chemistry there is a practice known as synthesis. This process is used to form complex chemical compounds from simpler ones. These complex compounds are desirable for their ranging abilities and properties. In order to produce the complex compounds, the simpler ones must “cooperate” in a specific way. This can be very difficult and requires patience, because of the time required to make the bonds so their uses and properties can be tested. There was a need for optimization of this process in order to speed up the development and testing of new compounds. Catellani and her team in 1997 found such a method to optimize this process.<ref>{{Cite journal|last=Liu|first=Ze-Shui|last2=Gao|first2=Qianwen|last3=Cheng|first3=Hong-Gang|last4=Zhou|first4=Qianghui|date=2018-10-17|title=Alkylating Reagents Employed in Catellani-Type Reactions|url=https://www.ncbi.nlm.nih.gov/pubmed/30016558|journal=Chemistry (Weinheim an Der Bergstrasse, Germany)|volume=24|issue=58|pages=15461–15476|doi=10.1002/chem.201802818|issn=1521-3765|pmid=30016558}}</ref> Catellani discovered a chain reaction process that simplified and increased yield for desirable complex compounds.<ref name=":02">{{Cite journal|last=Yamamoto|first=Y.|last2=Murayama|first2=T.|last3=Jiang|first3=J.|last4=Yasui|first4=T.|last5=Shibuya|first5=M.|date=2018-01-31|title=The vinylogous Catellani reaction: a combined computational and experimental study|url=https://pubs.rsc.org/en/content/articlelanding/2018/sc/c7sc04265e|journal=Chemical Science|language=en|volume=9|issue=5|pages=1191–1199|doi=10.1039/C7SC04265E|issn=2041-6539}}</ref> One bond the Catellani Reaction is heavily used to create is Carbon-Carbon bonds.<ref>{{Cite journal|last=Martins|first=Andrew|last2=Mariampillai|first2=Brian|last3=Lautens|first3=Mark|date=2010|title=Synthesis in the Key of Catellani: Norbornene-Mediated ortho C-H Functionalization|url=https://ui.adsabs.harvard.edu/abs/2010cha..book....1M/abstract|journal=cha|language=en|volume=292|pages=1|doi=10.1007/128_2009_13}}</ref> These bonds are desirable for their stability and strength.<ref>{{Cite web|title=Creating carbon–carbon bonds via transition metal catalysis|url=https://www.chemistryworld.com/chemistry-detectives/creating-carbon-carbon-bonds-via-transition-metal-catalysis/3010191.article|last=Wheeler2019-03-18T08:06:00+00:00|first=Philip|website=Chemistry World|language=en|access-date=2020-04-26}}</ref> These qualities make the bonds very useful in the makeup of more complex compounds.<ref name=":02" /> Since it's discovery, the Catellani Reaction has opened the door to other discoveries or improvements in chemistry. Specifically in the world of pharmaceuticals, the Catellani Reaction has been a useful tool for synthesizing drugs in a more efficient way to aid in their development. Lenoxipen is an example of one of the complex compounds now much easier to achieve with the discovery of Catellani Reactions.<ref name=":12">{{Cite journal|last=Weinstabl|first=Harald|last2=Suhartono|first2=Marcel|last3=Qureshi|first3=Zafar|last4=Lautens|first4=Mark|date=2013-05-10|title=Total Synthesis of (+)-Linoxepin by Utilizing the Catellani Reaction|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715096/|journal=Angewandte Chemie (International Ed. in English)|volume=52|issue=20|pages=5305–5308|doi=10.1002/anie.201302327|issn=1433-7851|pmc=3715096|pmid=23592590}}</ref> This compound belongs to a group of compounds known as Lignans that are useful for relieving pain and may provide benefits to cancer patients.<ref name=":12" /> These examples of the uses for Catellani Reactions show the vast and indirect benefits to its discovery. To chemists, the Catellani Reaction is a tool that acts to optimize the process for making new compounds. These new compounds are pivotal for advancing what is possible through chemistry. As new scientists study and try to build upon the Catellani Reaction, it is important to remember who provided the first understanding as it would open up a new world of opportunity. |
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== References == |
== References == |
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Revision as of 03:09, 9 May 2020
Marta Catellani is an Italian chemist known for her discovery of the eponymous Catellani reaction in 1997. She was elected to the European Academy of Sciences in 2016. Catellani earned her Ph.D. in chemistry in 1971 from the University of Parma, where, as of 2019, she is a professor and chairs the Department of Organic Chemistry.[1][2][3]
Catellani completed her postdoctoral education at the University of Chicago. She has served as a visiting professor at Moscow State University (1992), Beijing Institute of Technology (2004), and University of Xi'an (2004). She was awarded a fellowship at the Japan Society for the Promotion of Science in 2012.[2][3]
Her research focuses on palladium as a catalyst for multistep organic reactions.[2][3]
The Catellani Reaction
In chemistry there is a practice known as synthesis. This process is used to form complex chemical compounds from simpler ones. These complex compounds are desirable for their ranging abilities and properties. In order to produce the complex compounds, the simpler ones must “cooperate” in a specific way. This can be very difficult and requires patience, because of the time required to make the bonds so their uses and properties can be tested. There was a need for optimization of this process in order to speed up the development and testing of new compounds. Catellani and her team in 1997 found such a method to optimize this process.[4] Catellani discovered a chain reaction process that simplified and increased yield for desirable complex compounds.[5] One bond the Catellani Reaction is heavily used to create is Carbon-Carbon bonds.[6] These bonds are desirable for their stability and strength.[7] These qualities make the bonds very useful in the makeup of more complex compounds.[5] Since it's discovery, the Catellani Reaction has opened the door to other discoveries or improvements in chemistry. Specifically in the world of pharmaceuticals, the Catellani Reaction has been a useful tool for synthesizing drugs in a more efficient way to aid in their development. Lenoxipen is an example of one of the complex compounds now much easier to achieve with the discovery of Catellani Reactions.[8] This compound belongs to a group of compounds known as Lignans that are useful for relieving pain and may provide benefits to cancer patients.[8] These examples of the uses for Catellani Reactions show the vast and indirect benefits to its discovery. To chemists, the Catellani Reaction is a tool that acts to optimize the process for making new compounds. These new compounds are pivotal for advancing what is possible through chemistry. As new scientists study and try to build upon the Catellani Reaction, it is important to remember who provided the first understanding as it would open up a new world of opportunity.
References
- ^ "European Academy of Sciences - Marta Catellani". www.eurasc.org. Retrieved 2019-10-18.
- ^ a b c "Prof. Dr. Marta Catellani « ISHC 2018". Retrieved 2019-10-18.
- ^ a b c Olson, Julie A.; Shea, Kevin M. (2011-05-17). "Critical Perspective: Named Reactions Discovered and Developed by Women". Accounts of Chemical Research. 44 (5): 311–321. doi:10.1021/ar100114m. ISSN 0001-4842. PMID 21417324.
- ^ Liu, Ze-Shui; Gao, Qianwen; Cheng, Hong-Gang; Zhou, Qianghui (2018-10-17). "Alkylating Reagents Employed in Catellani-Type Reactions". Chemistry (Weinheim an Der Bergstrasse, Germany). 24 (58): 15461–15476. doi:10.1002/chem.201802818. ISSN 1521-3765. PMID 30016558.
- ^ a b Yamamoto, Y.; Murayama, T.; Jiang, J.; Yasui, T.; Shibuya, M. (2018-01-31). "The vinylogous Catellani reaction: a combined computational and experimental study". Chemical Science. 9 (5): 1191–1199. doi:10.1039/C7SC04265E. ISSN 2041-6539.
- ^ Martins, Andrew; Mariampillai, Brian; Lautens, Mark (2010). "Synthesis in the Key of Catellani: Norbornene-Mediated ortho C-H Functionalization". cha. 292: 1. doi:10.1007/128_2009_13.
- ^ Wheeler2019-03-18T08:06:00+00:00, Philip. "Creating carbon–carbon bonds via transition metal catalysis". Chemistry World. Retrieved 2020-04-26.
{{cite web}}: CS1 maint: numeric names: authors list (link) - ^ a b Weinstabl, Harald; Suhartono, Marcel; Qureshi, Zafar; Lautens, Mark (2013-05-10). "Total Synthesis of (+)-Linoxepin by Utilizing the Catellani Reaction". Angewandte Chemie (International Ed. in English). 52 (20): 5305–5308. doi:10.1002/anie.201302327. ISSN 1433-7851. PMC 3715096. PMID 23592590.
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