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Ricquier described in 1976 a mitochondrial membrane protein specific for brown adipocytes,<ref><abbr>(en)</abbr> Ricquier D., Kader J.C, « Mitochondrial protein alteration in active brown fat. A sodium dodecyl sulfate-polyacrylamide gel electrophoretic study », ''Biochem. Biophys'', 1976</ref> later named UCP ([[uncoupling protein]]) and identified by David Nicholls as the protein responsible for [[heat energy]] dissipation. Having isolated antibodies specific to this protein, he demonstrated brown adipocytes in [[neonates]] and adult patients and demonstrated that the [[sympathetic nervous system]] controls the development of brown adipose tissue and the synthesis of DCS in animals and humans.<ref><abbr>(en)</abbr> Ricquier D., Néchad M., Mory G, « Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma », ''J. Clin. Endocrinol. Metab'', 1982, <abbr>p.</abbr> 805 - 807</ref> With Fréderic Bouillaud, in 1984 and in collaboration with [[Jean Weissenbach]] at the [[Pasteur Institute]], he isolated and sequenced the complementary [[DNA]] of the UCP and the UCP gene from rodents and humans.<ref><abbr>(en)</abbr> Bouillaud F., Ricquier D., Thibault J., Weissenbach J., « Molecular approach to thermogenesis in brown adipose tissue : cDNA cloning of the mitochondrial uncoupling protein », ''Proc. Natl. Acad. Sci. USA'', 1985, <abbr>p.</abbr> 445 - 448</ref> He then analyzed the mechanisms of control of the tissue-specific transcription of the UCP gene. In addition, he studied the functional organization of this membrane protein.<ref><abbr>(en)</abbr> Cassard-Doulcier A-M., Gelly C., Fox N., Schrementi J., Raimbault S., Klaus S., Forest C., Bouillaud F., Ricquier D., « Tissue-specific and ß-adrenergic regulation of the mitochondrial uncoupling protein gene - Control by cis-acting elements in the 5'-flanking region. », ''Mol. Endocrinol'', 1993, <abbr>p.</abbr> 497-506</ref><ref><abbr>(en)</abbr> Miroux B., Frossart V., Raimbault S., Ricquier D., Bouillaud F., « The topology of the brown adipose tissue mitochondrial uncoupling protein determined with antibodies against its antigenic sites revealed by a library of fusion proteins », ''EMBO J. 12'', 1993, <abbr>p.</abbr> 3739-3745</ref><ref><abbr>(en)</abbr> Bouillaud F., Arechaga I., Petit P.X., Lévi-Meyrueis C., Casteilla L., Laurent M., Rial E., Ricquier D., « A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of the proton transport through the mitochondrial uncoupling protein », ''EMBO J 13'', 1994, <abbr>p.</abbr> 1990-1997</ref>
Ricquier described in 1976 a mitochondrial membrane protein specific for brown adipocytes,<ref><abbr>(en)</abbr> Ricquier D., Kader J.C, « Mitochondrial protein alteration in active brown fat. A sodium dodecyl sulfate-polyacrylamide gel electrophoretic study », ''Biochem. Biophys'', 1976</ref> later named UCP ([[uncoupling protein]]) and identified by David Nicholls as the protein responsible for [[heat energy]] dissipation. Having isolated antibodies specific to this protein, he demonstrated brown adipocytes in [[neonates]] and adult patients and demonstrated that the [[sympathetic nervous system]] controls the development of brown adipose tissue and the synthesis of DCS in animals and humans.<ref><abbr>(en)</abbr> Ricquier D., Néchad M., Mory G, « Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma », ''J. Clin. Endocrinol. Metab'', 1982, <abbr>p.</abbr> 805 - 807</ref> With Fréderic Bouillaud, in 1984 and in collaboration with [[Jean Weissenbach]] at the [[Pasteur Institute]], he isolated and sequenced the complementary [[DNA]] of the UCP and the UCP gene from rodents and humans.<ref><abbr>(en)</abbr> Bouillaud F., Ricquier D., Thibault J., Weissenbach J., « Molecular approach to thermogenesis in brown adipose tissue : cDNA cloning of the mitochondrial uncoupling protein », ''Proc. Natl. Acad. Sci. USA'', 1985, <abbr>p.</abbr> 445 - 448</ref> He then analyzed the mechanisms of control of the tissue-specific transcription of the UCP gene. In addition, he studied the functional organization of this membrane protein.<ref><abbr>(en)</abbr> Cassard-Doulcier A-M., Gelly C., Fox N., Schrementi J., Raimbault S., Klaus S., Forest C., Bouillaud F., Ricquier D., « Tissue-specific and ß-adrenergic regulation of the mitochondrial uncoupling protein gene - Control by cis-acting elements in the 5'-flanking region. », ''Mol. Endocrinol'', 1993, <abbr>p.</abbr> 497-506</ref><ref><abbr>(en)</abbr> Miroux B., Frossart V., Raimbault S., Ricquier D., Bouillaud F., « The topology of the brown adipose tissue mitochondrial uncoupling protein determined with antibodies against its antigenic sites revealed by a library of fusion proteins », ''EMBO J. 12'', 1993, <abbr>p.</abbr> 3739-3745</ref><ref><abbr>(en)</abbr> Bouillaud F., Arechaga I., Petit P.X., Lévi-Meyrueis C., Casteilla L., Laurent M., Rial E., Ricquier D., « A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of the proton transport through the mitochondrial uncoupling protein », ''EMBO J 13'', 1994, <abbr>p.</abbr> 1990-1997</ref>


Ricquier identified and characterized in 1997 a second UCP protein called UCP2,<ref name=":1"><abbr>(en)</abbr> Fleury C., Neverova M., Collins S., Raimbault S., Champigny O., Lévi- Meyrueis C., Bouillaud F., Seldin MF, Surwit RS, Ricquier D., Warden CH., « Uncoupling Protein-2 : a new thermogenic protein and a new gene linked to obesity and hyperinsulism », ''Nature Genetics 15'', 1997, <abbr>p.</abbr> 269-272</ref> the brown adipocyte UCP being renamed UCP1. He also identified a new cerebral mitochondrial transporter, BMCP,<ref>D. Sanchis, C. Fleury, N. Chomiki et M. Goubern, « BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast », ''The Journal of Biological Chemistry'', <abbr>vol.</abbr> 273, <abbr>n<sup>o</sup></abbr> 51, 18 décembre 1998, <abbr>p.</abbr> 34611–34615 <small>(ISSN 0021-9258, <nowiki>PMID 9852133</nowiki>, lire en ligne, consulté le 21 juillet 2017)</small></ref> an avian UCP<ref>S. Raimbault, S. Dridi, F. Denjean et J. Lachuer, « An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds », ''The Biochemical Journal'', <abbr>vol.</abbr> 353, <abbr>n<sup>o</sup></abbr> Pt 3, <abbr>1<sup>er</sup></abbr> février 2001, <abbr>p.</abbr> 441–444 <small>(ISSN 0264-6021, <nowiki>PMID 11171038</nowiki>, PMCID PMC1221587, lire en ligne, consulté le 21 juillet 2017)</small></ref> and a renal mitochondrial transporter KMCP<ref>Anne Haguenauer, Serge Raimbault, Sandrine Masscheleyn et Maria del Mar Gonzalez-Barroso, « A new renal mitochondrial carrier, KMCP1, is up-regulated during tubular cell regeneration and induction of antioxidant enzymes », ''The Journal of Biological Chemistry'', <abbr>vol.</abbr> 280, <abbr>n<sup>o</sup></abbr> 23, 10 juin 2005, <abbr>p.</abbr> 22036–22043 <small>(ISSN 0021-9258, <nowiki>PMID 15809292</nowiki>, DOI 10.1074/jbc.M412136200, lire en ligne, consulté le 21 juillet 2017)</small></ref> and contributed to the identification of the first plant UCP protein.<ref><abbr>(en)</abbr> Laloi M., Klein M., Resmeier J.W., Fleury C, Bouillaud F., Ricquier D., « A plant cold-induced uncoupling protein », ''Nature 389'', 1997, <abbr>p.</abbr> 135-136</ref> He was able to obtain mice without the UCP2 gene, demonstrating the essential role of this gene in innate immunity and the limitation of free radical levels,<ref>D. Arsenijevic, H. Onuma, C. Pecqueur et S. Raimbault, « Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production », ''Nature Genetics'', <abbr>vol.</abbr> 26, <abbr>n<sup>o</sup></abbr> 4, décembre 2000, <abbr>p.</abbr> 435–439 <small>(ISSN 1061-4036, <nowiki>PMID 11101840</nowiki>, DOI 10.1038/82565, lire en ligne, consulté le 21 juillet 2017)</small></ref><ref>Marie-Clotilde Alves-Guerra, Sophie Rousset, Claire Pecqueur et Ziad Mallat, « Bone marrow transplantation reveals the in vivo expression of the mitochondrial uncoupling protein 2 in immune and nonimmune cells during inflammation », ''The Journal of Biological Chemistry'', <abbr>vol.</abbr> 278, <abbr>n<sup>o</sup></abbr> 43, 24 octobre 2003, <abbr>p.</abbr> 42307–42312 <small>(ISSN 0021-9258, <nowiki>PMID 12907675</nowiki>, DOI 10.1074/jbc.M306951200, lire en ligne, consulté le 21 juillet 2017)</small></ref><ref>Yalin Emre, Corinne Hurtaud, Tobias Nübel et François Criscuolo, « Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages », ''The Biochemical Journal'', <abbr>vol.</abbr> 402, <abbr>n<sup>o</sup></abbr> 2, <abbr>1<sup>er</sup></abbr> mars 2007, <abbr>p.</abbr> 271–278 <small>(ISSN 1470-8728, <nowiki>PMID 17073824</nowiki>, PMCID PMC1798432, DOI 10.1042/BJ20061430, lire en ligne, consulté le 21 juillet 2017)</small></ref> particularly in macrophages in collaboration with Denis Richard at [[Université Laval|Laval University]]. This function of UCP2 has been confirmed by the demonstration of a protective role of UCP2 against atherosclerosis.<ref>J. Blanc, M. C. Alves-Guerra, B. Esposito et S. Rousset, « Protective role of uncoupling protein 2 in atherosclerosis », ''Circulation'', <abbr>vol.</abbr> 107, <abbr>n<sup>o</sup></abbr> 3, 28 janvier 2003, <abbr>p.</abbr> 388–390 <small>(ISSN 1524-4539, <nowiki>PMID 12551860</nowiki>, lire en ligne, consulté le 21 juillet 2017)</small></ref>
Ricquier identified and characterized in 1997 a second UCP protein called UCP2,<ref name=":1"><abbr>(en)</abbr> Fleury C., Neverova M., Collins S., Raimbault S., Champigny O., Lévi- Meyrueis C., Bouillaud F., Seldin MF, Surwit RS, Ricquier D., Warden CH., « Uncoupling Protein-2 : a new thermogenic protein and a new gene linked to obesity and hyperinsulism », ''Nature Genetics 15'', 1997, <abbr>p.</abbr> 269-272</ref> the brown adipocyte UCP being renamed UCP1. He also identified a new cerebral mitochondrial transporter, BMCP,<ref>{{cite journal |pmid=9852133|year=1998|last1=Sanchis|first1=D.|last2=Fleury|first2=C.|last3=Chomiki|first3=N.|last4=Goubern|first4=M.|last5=Huang|first5=Q.|last6=Neverova|first6=M.|last7=Grégoire|first7=F.|last8=Easlick|first8=J.|last9=Raimbault|first9=S.|last10=Lévi-Meyrueis|first10=C.|last11=Miroux|first11=B.|last12=Collins|first12=S.|last13=Seldin|first13=M.|last14=Richard|first14=D.|last15=Warden|first15=C.|last16=Bouillaud|first16=F.|last17=Ricquier|first17=D.|s2cid=21178898|title=BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast|journal=The Journal of Biological Chemistry|volume=273|issue=51|pages=34611–5|doi=10.1074/jbc.273.51.34611}}</ref> an avian UCP<ref>{{cite journal |pmid=11171038|year=2001|last1=Raimbault|first1=S.|last2=Dridi|first2=S.|last3=Denjean|first3=F.|last4=Lachuer|first4=J.|last5=Couplan|first5=E.|last6=Bouillaud|first6=F.|last7=Bordas|first7=A.|last8=Duchamp|first8=C.|last9=Taouis|first9=M.|last10=Ricquier|first10=D.|title=An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds|journal=The Biochemical Journal|volume=353|issue=Pt 3|pages=441–4|doi=10.1042/0264-6021:3530441|pmc=1221587}}</ref> and a renal mitochondrial transporter KMCP<ref>Anne Haguenauer, Serge Raimbault, Sandrine {{cite journal |pmid=15809292|year=2005|last1=Haguenauer|first1=A.|last2=Raimbault|first2=S.|last3=Masscheleyn|first3=S.|last4=Gonzalez-Barroso Mdel|first4=M.|last5=Criscuolo|first5=F.|last6=Plamondon|first6=J.|last7=Miroux|first7=B.|last8=Ricquier|first8=D.|last9=Richard|first9=D.|last10=Bouillaud|first10=F.|last11=Pecqueur|first11=C.|s2cid=1176549|title=A new renal mitochondrial carrier, KMCP1, is up-regulated during tubular cell regeneration and induction of antioxidant enzymes|journal=The Journal of Biological Chemistry|volume=280|issue=23|pages=22036–43|doi=10.1074/jbc.M412136200}}</ref> and contributed to the identification of the first plant UCP protein.<ref><abbr>(en)</abbr> Laloi M., Klein M., Resmeier J.W., Fleury C, Bouillaud F., Ricquier D., « A plant cold-induced uncoupling protein », ''Nature 389'', 1997, <abbr>p.</abbr> 135-136</ref> He was able to obtain mice without the UCP2 gene, demonstrating the essential role of this gene in innate immunity and the limitation of free radical levels,<ref>{{cite journal |pmid=11101840|year=2000|last1=Arsenijevic|first1=D.|last2=Onuma|first2=H.|last3=Pecqueur|first3=C.|last4=Raimbault|first4=S.|last5=Manning|first5=B. S.|last6=Miroux|first6=B.|last7=Couplan|first7=E.|last8=Alves-Guerra|first8=M. C.|last9=Goubern|first9=M.|last10=Surwit|first10=R.|last11=Bouillaud|first11=F.|last12=Richard|first12=D.|last13=Collins|first13=S.|last14=Ricquier|first14=D.|s2cid=29831657|title=Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production|journal=Nature Genetics|volume=26|issue=4|pages=435–9|doi=10.1038/82565}}</ref><ref>{{cite journal |pmid=12907675|year=2003|last1=Alves-Guerra|first1=M. C.|last2=Rousset|first2=S.|last3=Pecqueur|first3=C.|last4=Mallat|first4=Z.|last5=Blanc|first5=J.|last6=Tedgui|first6=A.|last7=Bouillaud|first7=F.|last8=Cassard-Doulcier|first8=A. M.|last9=Ricquier|first9=D.|last10=Miroux|first10=B.|s2cid=23245867|title=Bone marrow transplantation reveals the in vivo expression of the mitochondrial uncoupling protein 2 in immune and nonimmune cells during inflammation|journal=The Journal of Biological Chemistry|volume=278|issue=43|pages=42307–12|doi=10.1074/jbc.M306951200}}</ref><ref>{{cite journal |pmid=17073824|year=2007|last1=Emre|first1=Y.|last2=Hurtaud|first2=C.|last3=Nübel|first3=T.|last4=Criscuolo|first4=F.|last5=Ricquier|first5=D.|last6=Cassard-Doulcier|first6=A. M.|title=Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages|journal=The Biochemical Journal|volume=402|issue=2|pages=271–8|doi=10.1042/BJ20061430|pmc=1798432}}</ref> particularly in macrophages in collaboration with Denis Richard at [[Université Laval|Laval University]]. This function of UCP2 has been confirmed by the demonstration of a protective role of UCP2 against atherosclerosis.<ref>{{cite journal |pmid=12551860|year=2003|last1=Blanc|first1=J.|last2=Alves-Guerra|first2=M. C.|last3=Esposito|first3=B.|last4=Rousset|first4=S.|last5=Gourdy|first5=P.|last6=Ricquier|first6=D.|last7=Tedgui|first7=A.|last8=Miroux|first8=B.|last9=Mallat|first9=Z.|title=Protective role of uncoupling protein 2 in atherosclerosis|journal=Circulation|volume=107|issue=3|pages=388–90|doi=10.1161/01.cir.0000051722.66074.60}}</ref>


Ricquier has demonstrated that mutations in the UCP2 protein induce congenital [[hyperinsulinism]] in children at birth.<ref>M. Mar González-Barroso, Irina Giurgea, Fredéric Bouillaud et Andrea Anedda, « Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion », ''PloS One'', <abbr>vol.</abbr> 3, <abbr>n<sup>o</sup></abbr> 12, 2008, e3850 <small>(ISSN 1932-6203, <nowiki>PMID 19065272</nowiki>, PMCID PMC2588657, DOI 10.1371/journal.pone.0003850, lire en ligne, consulté le 21 juillet 2017)</small></ref> He also described a protective role for UCP2 against autoimmune diabetes.<ref>Yalin Emre, Corinne Hurtaud, Melis Karaca et Tobias Nubel, « Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes », ''Proceedings of the National Academy of Sciences of the United States of America'', <abbr>vol.</abbr> 104, <abbr>n<sup>o</sup></abbr> 48, 27 novembre 2007, <abbr>p.</abbr> 19085–19090 <small>(ISSN 1091-6490, <nowiki>PMID 18006654</nowiki>, PMCID PMC2141912, DOI 10.1073/pnas.0709557104, lire en ligne, consulté le 21 juillet 2017)</small></ref> Applications of the work include metabolic diseases (obesity, diabetes), nutrition, [[degenerative disease]]s and [[autoimmune disease]]s involving oxygenated free radicals in [[atherosclerosis]] and [[neurodegeneration]]. 
Ricquier has demonstrated that mutations in the UCP2 protein induce congenital [[hyperinsulinism]] in children at birth.<ref>{{cite journal |pmid=19065272|year=2008|last1=González-Barroso|first1=M. M.|last2=Giurgea|first2=I.|last3=Bouillaud|first3=F.|last4=Anedda|first4=A.|last5=Bellanné-Chantelot|first5=C.|last6=Hubert|first6=L.|last7=De Keyzer|first7=Y.|last8=De Lonlay|first8=P.|last9=Ricquier|first9=D.|title=Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion|journal=PLOS ONE|volume=3|issue=12|pages=e3850|doi=10.1371/journal.pone.0003850|pmc=2588657|bibcode=2008PLoSO...3.3850G}}</ref> He also described a protective role for UCP2 against autoimmune diabetes.<ref>{{cite journal |pmid=18006654|year=2007|last1=Emre|first1=Y.|last2=Hurtaud|first2=C.|last3=Karaca|first3=M.|last4=Nubel|first4=T.|last5=Zavala|first5=F.|last6=Ricquier|first6=D.|title=Role of uncoupling protein UCP2 in cell-mediated immunity: How macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=104|issue=48|pages=19085–90|doi=10.1073/pnas.0709557104|pmc=2141912|bibcode=2007PNAS..10419085E}}</ref> Applications of the work include metabolic diseases (obesity, diabetes), nutrition, [[degenerative disease]]s and [[autoimmune disease]]s involving oxygenated free radicals in [[atherosclerosis]] and [[neurodegeneration]]. 


== Honours ==
== Honours ==

Revision as of 16:53, 9 July 2020

Daniel Ricquier (born 19 May 1949), is a French biochemist known for his work in mitochondria and hereditary metabolic diseases.[1] Ricquier has been a member of the French Academy of Sciences since 2002,[1] and a professor of biochemistry and Molecular Biology at the Faculty of Medicine of the University of Paris Descartes since 2003.[2]

Daniel Riquier - December 2016

Biography

Ricquier is a university professor and hospital practitioner at faculté́ of medicine at the University of Paris-Descartes, and at the Necker-Enfants malades Hospital,[3] since 2003.

He directed the "Centre de recherche sur l'endocrinologie moléculaire et le développement" of the CNRS in Meudon from 1997 to 2002, then the CNRS unit "Biologie des Transporteurs mitochondriaux et métabolisme" from 2002 to 2008 at faculté́ de médecine Necker Paris Descartes and at the Institut de recherches Necker-Enfants Malades. He was Head of the Metabolic Biochemistry Department at Necker Enfants Malades Hospital and at AP-HP from 2003 to 2014. He was elected a member of the Academy of Sciences on 19 November 2002.[1]

Works

Ricquier specializes in the physiology and biochemistry of mitochondria, adipose tissue and thermogenic mechanisms. He is an expert on brown adipose tissue. His work has contribué́ to identify a family of proteins involved in mitochondrial respiration, ATP yield, heat production and mitochondrial control of the level of cellular oxygenated free radicals.

Ricquier described in 1976 a mitochondrial membrane protein specific for brown adipocytes,[4] later named UCP (uncoupling protein) and identified by David Nicholls as the protein responsible for heat energy dissipation. Having isolated antibodies specific to this protein, he demonstrated brown adipocytes in neonates and adult patients and demonstrated that the sympathetic nervous system controls the development of brown adipose tissue and the synthesis of DCS in animals and humans.[5] With Fréderic Bouillaud, in 1984 and in collaboration with Jean Weissenbach at the Pasteur Institute, he isolated and sequenced the complementary DNA of the UCP and the UCP gene from rodents and humans.[6] He then analyzed the mechanisms of control of the tissue-specific transcription of the UCP gene. In addition, he studied the functional organization of this membrane protein.[7][8][9]

Ricquier identified and characterized in 1997 a second UCP protein called UCP2,[10] the brown adipocyte UCP being renamed UCP1. He also identified a new cerebral mitochondrial transporter, BMCP,[11] an avian UCP[12] and a renal mitochondrial transporter KMCP[13] and contributed to the identification of the first plant UCP protein.[14] He was able to obtain mice without the UCP2 gene, demonstrating the essential role of this gene in innate immunity and the limitation of free radical levels,[15][16][17] particularly in macrophages in collaboration with Denis Richard at Laval University. This function of UCP2 has been confirmed by the demonstration of a protective role of UCP2 against atherosclerosis.[18]

Ricquier has demonstrated that mutations in the UCP2 protein induce congenital hyperinsulinism in children at birth.[19] He also described a protective role for UCP2 against autoimmune diabetes.[20] Applications of the work include metabolic diseases (obesity, diabetes), nutrition, degenerative diseases and autoimmune diseases involving oxygenated free radicals in atherosclerosis and neurodegeneration. 

Honours

  • 1988: Paul Langevin Prize from the French Academy of sciences
  • 1989: CNRS silver medal
  • 1995: F. Wasserman Medal of the European Association for the Study of Obesity[21]
  • 2000: Grand Prix des industries agro-alimentaires from the French Academy of sciences
  • 2002: Member of the French Academy of sciences[1]
  • 2002: Wertheimer Medal from the International Association of Study on Obesity
  • 2013: Chevalier in the Ordre de la Légion d'Honneur[22]
  • 2012-2017: Deputy Vice-President for International Relations of the French Academy of sciences[1]

References

  1. ^ a b c d e User, Super. "Daniel Ricquier | Liste des membres de l'Académie des sciences / R | Listes par ordre alphabétique | Listes des membres | Membres | Nous connaître". www.academie-sciences.fr (in French). Retrieved 2017-01-23. {{cite web}}: |last= has generic name (help)
  2. ^ Biomédicale, RIB UFR. Ricquier.jpg|thumb|Daniel Ricquier - December 2016%5d%5d/biochimie.html "biochimie - [Faculté des Sciences Fondamentales et Biomédicales]". www.biomedicale.parisdescartes.fr (in French). Retrieved 2017-01-23. {{cite web}}: Check |url= value (help)
  3. ^ "Biochimie métabolomique et protéomique". Hôpital Necker-Enfants malades. 2016-10-17. Retrieved 2017-01-23.
  4. ^ (en) Ricquier D., Kader J.C, « Mitochondrial protein alteration in active brown fat. A sodium dodecyl sulfate-polyacrylamide gel electrophoretic study », Biochem. Biophys, 1976
  5. ^ (en) Ricquier D., Néchad M., Mory G, « Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma », J. Clin. Endocrinol. Metab, 1982, p. 805 - 807
  6. ^ (en) Bouillaud F., Ricquier D., Thibault J., Weissenbach J., « Molecular approach to thermogenesis in brown adipose tissue : cDNA cloning of the mitochondrial uncoupling protein », Proc. Natl. Acad. Sci. USA, 1985, p. 445 - 448
  7. ^ (en) Cassard-Doulcier A-M., Gelly C., Fox N., Schrementi J., Raimbault S., Klaus S., Forest C., Bouillaud F., Ricquier D., « Tissue-specific and ß-adrenergic regulation of the mitochondrial uncoupling protein gene - Control by cis-acting elements in the 5'-flanking region. », Mol. Endocrinol, 1993, p. 497-506
  8. ^ (en) Miroux B., Frossart V., Raimbault S., Ricquier D., Bouillaud F., « The topology of the brown adipose tissue mitochondrial uncoupling protein determined with antibodies against its antigenic sites revealed by a library of fusion proteins », EMBO J. 12, 1993, p. 3739-3745
  9. ^ (en) Bouillaud F., Arechaga I., Petit P.X., Lévi-Meyrueis C., Casteilla L., Laurent M., Rial E., Ricquier D., « A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of the proton transport through the mitochondrial uncoupling protein », EMBO J 13, 1994, p. 1990-1997
  10. ^ (en) Fleury C., Neverova M., Collins S., Raimbault S., Champigny O., Lévi- Meyrueis C., Bouillaud F., Seldin MF, Surwit RS, Ricquier D., Warden CH., « Uncoupling Protein-2 : a new thermogenic protein and a new gene linked to obesity and hyperinsulism », Nature Genetics 15, 1997, p. 269-272
  11. ^ Sanchis, D.; Fleury, C.; Chomiki, N.; Goubern, M.; Huang, Q.; Neverova, M.; Grégoire, F.; Easlick, J.; Raimbault, S.; Lévi-Meyrueis, C.; Miroux, B.; Collins, S.; Seldin, M.; Richard, D.; Warden, C.; Bouillaud, F.; Ricquier, D. (1998). "BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast". The Journal of Biological Chemistry. 273 (51): 34611–5. doi:10.1074/jbc.273.51.34611. PMID 9852133. S2CID 21178898.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  12. ^ Raimbault, S.; Dridi, S.; Denjean, F.; Lachuer, J.; Couplan, E.; Bouillaud, F.; Bordas, A.; Duchamp, C.; Taouis, M.; Ricquier, D. (2001). "An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds". The Biochemical Journal. 353 (Pt 3): 441–4. doi:10.1042/0264-6021:3530441. PMC 1221587. PMID 11171038.
  13. ^ Anne Haguenauer, Serge Raimbault, Sandrine Haguenauer, A.; Raimbault, S.; Masscheleyn, S.; Gonzalez-Barroso Mdel, M.; Criscuolo, F.; Plamondon, J.; Miroux, B.; Ricquier, D.; Richard, D.; Bouillaud, F.; Pecqueur, C. (2005). "A new renal mitochondrial carrier, KMCP1, is up-regulated during tubular cell regeneration and induction of antioxidant enzymes". The Journal of Biological Chemistry. 280 (23): 22036–43. doi:10.1074/jbc.M412136200. PMID 15809292. S2CID 1176549.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  14. ^ (en) Laloi M., Klein M., Resmeier J.W., Fleury C, Bouillaud F., Ricquier D., « A plant cold-induced uncoupling protein », Nature 389, 1997, p. 135-136
  15. ^ Arsenijevic, D.; Onuma, H.; Pecqueur, C.; Raimbault, S.; Manning, B. S.; Miroux, B.; Couplan, E.; Alves-Guerra, M. C.; Goubern, M.; Surwit, R.; Bouillaud, F.; Richard, D.; Collins, S.; Ricquier, D. (2000). "Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production". Nature Genetics. 26 (4): 435–9. doi:10.1038/82565. PMID 11101840. S2CID 29831657.
  16. ^ Alves-Guerra, M. C.; Rousset, S.; Pecqueur, C.; Mallat, Z.; Blanc, J.; Tedgui, A.; Bouillaud, F.; Cassard-Doulcier, A. M.; Ricquier, D.; Miroux, B. (2003). "Bone marrow transplantation reveals the in vivo expression of the mitochondrial uncoupling protein 2 in immune and nonimmune cells during inflammation". The Journal of Biological Chemistry. 278 (43): 42307–12. doi:10.1074/jbc.M306951200. PMID 12907675. S2CID 23245867.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  17. ^ Emre, Y.; Hurtaud, C.; Nübel, T.; Criscuolo, F.; Ricquier, D.; Cassard-Doulcier, A. M. (2007). "Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages". The Biochemical Journal. 402 (2): 271–8. doi:10.1042/BJ20061430. PMC 1798432. PMID 17073824.
  18. ^ Blanc, J.; Alves-Guerra, M. C.; Esposito, B.; Rousset, S.; Gourdy, P.; Ricquier, D.; Tedgui, A.; Miroux, B.; Mallat, Z. (2003). "Protective role of uncoupling protein 2 in atherosclerosis". Circulation. 107 (3): 388–90. doi:10.1161/01.cir.0000051722.66074.60. PMID 12551860.
  19. ^ González-Barroso, M. M.; Giurgea, I.; Bouillaud, F.; Anedda, A.; Bellanné-Chantelot, C.; Hubert, L.; De Keyzer, Y.; De Lonlay, P.; Ricquier, D. (2008). "Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion". PLOS ONE. 3 (12): e3850. Bibcode:2008PLoSO...3.3850G. doi:10.1371/journal.pone.0003850. PMC 2588657. PMID 19065272.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  20. ^ Emre, Y.; Hurtaud, C.; Karaca, M.; Nubel, T.; Zavala, F.; Ricquier, D. (2007). "Role of uncoupling protein UCP2 in cell-mediated immunity: How macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes". Proceedings of the National Academy of Sciences of the United States of America. 104 (48): 19085–90. Bibcode:2007PNAS..10419085E. doi:10.1073/pnas.0709557104. PMC 2141912. PMID 18006654.
  21. ^ "EASO Award and Travel Grant Winners – 1995". easo.org. Retrieved 2017-01-23.
  22. ^ Décret du 29 mars 2013  portant promotion et nomination
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