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In 1998, the change of focus in the human genome project redirected US Department of Energy funds which were previously available for GDB.<ref name="gdb-sackings">{{cite journal |last1=Bonetta |first1=Laura |title=Sackings leave gene database floundering |journal=Nature |date=November 2001 |volume=414 |issue=6862 |pages=384–384 |doi=10.1038/35106703}}</ref> However that same year, [[A. Jamie Cuticchia]] obtained funding from Canadian public and private sources to continue the operations of GDB. While the data curation continued to be performed at Johns Hopkins, GDB central operations were moved to The Hospital for Sick Children (HSC) in Toronto, Ontario, Canada.<ref name="canada-move">{{cite web |title=Human Genome News Vol.10,No.1-2, February 1999 |url=https://web.ornl.gov/sci/techresources/Human_Genome/publicat/hgn/v10n1/21gdb.shtml |website=web.ornl.gov |accessdate=3 September 2020}}</ref> In November 2001, the HSC fired Cuticchia due to a dispute over the GDB website domain name.<ref name="gdb-sackings" />
In 1998, the change of focus in the human genome project redirected US Department of Energy funds which were previously available for GDB.<ref name="gdb-sackings">{{cite journal |last1=Bonetta |first1=Laura |title=Sackings leave gene database floundering |journal=Nature |date=November 2001 |volume=414 |issue=6862 |pages=384–384 |doi=10.1038/35106703}}</ref> However that same year, [[A. Jamie Cuticchia]] obtained funding from Canadian public and private sources to continue the operations of GDB. While the data curation continued to be performed at Johns Hopkins, GDB central operations were moved to The Hospital for Sick Children (HSC) in Toronto, Ontario, Canada.<ref name="canada-move">{{cite web |title=Human Genome News Vol.10,No.1-2, February 1999 |url=https://web.ornl.gov/sci/techresources/Human_Genome/publicat/hgn/v10n1/21gdb.shtml |website=web.ornl.gov |accessdate=3 September 2020}}</ref> In November 2001, the HSC fired Cuticchia due to a dispute over the GDB website domain name.<ref name="gdb-sackings" />


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In 2003 [[RTI International]] became the new host for GDB where it continued to be maintained as a public resource;<ref>{{cite journal |last1=Seewald |first1=A.K. |title=Ranking for BioMinT: investigating performance, local search and homonymy recognition |journal=Proceedings of the Symposium on Knowledge Exploration in Life Science Informatics (KELSI 2004) |date=2004 |url=http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.117.8840}}</ref> GDB was closed in 2008 after control of the project reverted to Johns Hopkins.<ref name="closure">{{cite journal |last1=Galperin |first1=M. Y. |last2=Cochrane |first2=G. R. |title=Nucleic Acids Research annual Database Issue and the NAR online Molecular Biology Database Collection in 2009 |journal=Nucleic Acids Research |date=1 January 2009 |volume=37 |issue=Database |pages=D1–D4 |doi=10.1093/nar/gkn942}}</ref>
In 2003 [[RTI International]] became the new host for GDB where it continued to be maintained as a public resource for high quality genetic and genomic information.{{cn|date=September 2020}}

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GDB was closed in 2008 after control of the project reverted to Johns Hopkins.<ref name="closure">{{cite journal |last1=Galperin |first1=M. Y. |last2=Cochrane |first2=G. R. |title=Nucleic Acids Research annual Database Issue and the NAR online Molecular Biology Database Collection in 2009 |journal=Nucleic Acids Research |date=1 January 2009 |volume=37 |issue=Database |pages=D1–D4 |doi=10.1093/nar/gkn942}}</ref>


==References==
==References==

Revision as of 13:57, 4 September 2020

The GDB Human Genome Database was a community curated collection of human genomic data.

History

In 1989 the Howard Hughes Medical Institute provided funding to establish a central repository for human genetic mapping data. This project ultimately resulted in the creation of the GDB Human Genome DataBase in September 1990.[1][2] It was a key database in the Human Genome Project.[3][4] In order to ensure a high degree of quality, records within GDB were subjected to a curation process by human genetics specialists, including the HUGO Gene Nomenclature Committee.[5]

Established under the leadership of Peter Pearson and Dick Lucier,[6] GDB received financial support from the US Department of Energy and the National Institutes of Health.[1] Located at the Johns Hopkins University School of Medicine, GDB became a source of high quality mapping data which were made available both online as well as through numerous printed publications.[citation needed] The project was supported internationally by the EU, Japan, and other countries.

The GDB had several directors in its time. Peter Pearson, David T. Kingsbury, Stantley Letovsky, Peter Li, and A. Jamie Cuticchia.[citation needed]

In 1998, the change of focus in the human genome project redirected US Department of Energy funds which were previously available for GDB.[7] However that same year, A. Jamie Cuticchia obtained funding from Canadian public and private sources to continue the operations of GDB. While the data curation continued to be performed at Johns Hopkins, GDB central operations were moved to The Hospital for Sick Children (HSC) in Toronto, Ontario, Canada.[8] In November 2001, the HSC fired Cuticchia due to a dispute over the GDB website domain name.[7]

In 2003 RTI International became the new host for GDB where it continued to be maintained as a public resource;[9] GDB was closed in 2008 after control of the project reverted to Johns Hopkins.[10]

References

  1. ^ a b Cuticchia, A.Jamie; Fasman, Kenneth H.; Kingsbury, David T.; Robbins, Robert J.; Pearson, Peter L. (1993). "The GDB TM human genome data base anno 1993". Nucleic Acids Research. 21 (13): 3003–3006. doi:10.1093/nar/21.13.3003.
  2. ^ Cuticchia, A.J. (27 Dec 1999). "Future vision of the GDB human genome database". Human Mutation. 15 (1): 62–67. doi:0.1002/(SICI)1098-1004(200001)15:1<62::AID-HUMU13>3.0.CO;2-R. PMID 10612824. {{cite journal}}: Check |doi= value (help)
  3. ^ "Human Genome News, September-December 1995: 7(3-4):15". web.ornl.gov.
  4. ^ Guyer, M. S.; Collins, F. S. (21 November 1995). "How is the Human Genome Project doing, and what have we learned so far?". Proceedings of the National Academy of Sciences. 92 (24): 10841–10848. doi:10.1073/pnas.92.24.10841.
  5. ^ Letovsky, S. (1 January 1998). "GDB: the Human Genome Database". Nucleic Acids Research. 26 (1): 94–99. doi:10.1093/nar/26.1.94.
  6. ^ Pearson, P.L. (25 April 1991). "The genome data base (GDB)--a human gene mapping repository". Nucleic Acids Research. 19 (suppl): 2237–2239. doi:10.1093/nar/19.suppl.2237.
  7. ^ a b Bonetta, Laura (November 2001). "Sackings leave gene database floundering". Nature. 414 (6862): 384–384. doi:10.1038/35106703.
  8. ^ "Human Genome News Vol.10,No.1-2, February 1999". web.ornl.gov. Retrieved 3 September 2020.
  9. ^ Seewald, A.K. (2004). "Ranking for BioMinT: investigating performance, local search and homonymy recognition". Proceedings of the Symposium on Knowledge Exploration in Life Science Informatics (KELSI 2004).
  10. ^ Galperin, M. Y.; Cochrane, G. R. (1 January 2009). "Nucleic Acids Research annual Database Issue and the NAR online Molecular Biology Database Collection in 2009". Nucleic Acids Research. 37 (Database): D1–D4. doi:10.1093/nar/gkn942.
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