The 1999–2000 season was the 73rd season in the existence of U.S. Lecce and the club's first season back in the top flight of Italian football. In addition to the domestic league, Lecce participated in this season's edition of the Coppa Italia.
Players
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Source: Serie A, RSSSF.com, Soccerway Rules for classification: 1) Points; 2) Head-to-head points; 3) Head-to-head goal difference; 4) Goal difference; 5) Goals scored; 6) Draw. (Note: Head-to-head record is used only after all the matches between the teams in question have been played).[1] (R) Relegated Notes:
^ abcREG: 9 pts; BOL: 4 pts → BOL 2–0 LEC; LEC: 4 pts → LEC 1–1 BOL