In October 1983, the 1 AES deployed to Grenada in support of Operation Urgent Fury. The squadron aeromedically evacuated numerous casualties during the operation. From December 1989 through January 1990, the 1 AES was deployed in support of Operation Just Cause. During this period, 1 AES personnel established and supported the Joint Casualty Collection Point at Howard AFB, Panama. In addition to providing life-saving intervention and treatment of combat casualties, 1 AES personnel aeromedically evacuated wounded soldiers to stateside medical treatment facilities.
On 10 August 1990, the 1 AES deployed personnel to the Middle East for support of theater aeromedical operations in Operation Desert Shield. During Operations Desert Shield and Desert Storm, thousands of theater and strategic patient movements were managed by 1 AES personnel. Following these operations, the 1 AES deployed personnel in support of Operation Provide Comfort from May through October 1991. The squadron also provided support for US forces in Somalia in Operation Restore Hope. The 1 AES deployed to Mogadishu, Somalia, on 18 December 1992 and managed more patient movements on aeromedical evacuation missions.