ACTR1B
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| ARP1 actin-related protein 1 homolog B, centractin beta (yeast) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | ACTR1B; ARP1B; CTRN2; PC3 | ||||||||||
| External IDs | OMIM: 605144 MGI: 1917446 HomoloGene: 101541 GeneCards: ACTR1B Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 10120 | 226977 | |||||||||
| Ensembl | ENSG00000115073 | ENSMUSG00000037351 | |||||||||
| UniProt | P42025 | Q8R5C5 | |||||||||
| RefSeq (mRNA) | NM_005735.3 | NM_146107.2 | |||||||||
| RefSeq (protein) | NP_005726.1 | NP_666219.1 | |||||||||
| Location (UCSC) | Chr 2: 98.27 – 98.28 Mb |
Chr 1: 36.76 – 36.77 Mb |
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| PubMed search | [1] | [2] | |||||||||
Beta-centractin is a protein that in humans is encoded by the ACTR1B gene.[1][2][3]
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER[disambiguation needed 
]-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.[3]
[edit] References
- ^ Clark SW, Staub O, Clark IB, Holzbaur EL, Paschal BM, Vallee RB, Meyer DI (May 1995). "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins". Mol Biol Cell 5 (12): 1301–10. PMC 301159. PMID 7696711. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=301159.
- ^ Elsea SH, Clark IB, Juyal RC, Meyer DJ, Meyer DI, Patel PI (Jun 1999). "Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization". Cytogenet Cell Genet 84 (1–2): 48–9. doi:10.1159/000015211. PMID 10343100.
- ^ a b "Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10120.
[edit] Further reading
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Eckley DM, Schroer TA (2004). "Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1". Mol. Biol. Cell 14 (7): 2645–54. doi:10.1091/mbc.E03-01-0049. PMC 165665. PMID 12857853. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=165665.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732.
- Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes". Nature 355 (6361): 632–4. doi:10.1038/355632a0. PMID 1538749.
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