ACTR1B

From Wikipedia, the free encyclopedia
Jump to: navigation, search
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
Identifiers
Symbols ACTR1B ; ARP1B; CTRN2; PC3
External IDs OMIM605144 MGI1917446 HomoloGene101541 GeneCards: ACTR1B Gene
RNA expression pattern
PBB GE ACTR1B 202135 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10120 226977
Ensembl ENSG00000115073 ENSMUSG00000037351
UniProt P42025 Q8R5C5
RefSeq (mRNA) NM_005735 NM_146107
RefSeq (protein) NP_005726 NP_666219
Location (UCSC) Chr 2:
98.27 – 98.28 Mb
Chr 1:
36.7 – 36.71 Mb
PubMed search [1] [2]

Beta-centractin is a protein that in humans is encoded by the ACTR1B gene.[1][2][3]

This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.[3]

References[edit]

  1. ^ Clark SW, Staub O, Clark IB, Holzbaur EL, Paschal BM, Vallee RB, Meyer DI (May 1995). "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins". Mol Biol Cell 5 (12): 1301–10. doi:10.1091/mbc.5.12.1301. PMC 301159. PMID 7696711. 
  2. ^ Elsea SH, Clark IB, Juyal RC, Meyer DJ, Meyer DI, Patel PI (Jun 1999). "Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization". Cytogenet Cell Genet 84 (1–2): 48–9. doi:10.1159/000015211. PMID 10343100. 
  3. ^ a b "Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)". 

Further reading[edit]

External links[edit]