ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1gene.
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.
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Hong JX, Lee FJ, Patton WA, et al. (1998). "Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1).". J. Biol. Chem.273 (25): 15872–6. doi:10.1074/jbc.273.25.15872. PMID9624189.
Zhao L, Helms JB, Brunner J, Wieland FT (1999). "GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23.". J. Biol. Chem.274 (20): 14198–203. doi:10.1074/jbc.274.20.14198. PMID10318838.
Van Valkenburgh H, Shern JF, Sharer JD, et al. (2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins.". J. Biol. Chem.276 (25): 22826–37. doi:10.1074/jbc.M102359200. PMID11303027.
Zahn C, Hommel A, Lu L, et al. (2007). "Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells.". Mol. Membr. Biol.23 (6): 475–85. doi:10.1080/09687860600840100. PMID17127620.