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ADP-ribosylation factor-like 1
Protein ARL1 PDB 1r4a.png
PDB rendering based on 1r4a.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ARL1 ; ARFL1
External IDs OMIM603425 MGI99436 HomoloGene20319 GeneCards: ARL1 Gene
RNA expression pattern
PBB GE ARL1 201659 s at tn.png
PBB GE ARL1 201657 at tn.png
PBB GE ARL1 201658 at tn.png
More reference expression data
Species Human Mouse
Entrez 400 104303
Ensembl ENSG00000120805 ENSMUSG00000060904
UniProt P40616 P61211
RefSeq (mRNA) NM_001177 NM_025859
RefSeq (protein) NP_001168 NP_080135
Location (UCSC) Chr 12:
101.79 – 101.8 Mb
Chr 10:
88.73 – 88.74 Mb
PubMed search [1] [2]

ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.[1]

The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.[1]


ARL1 has been shown to interact with GOLGA4[2][3] and GOLGA1.[2]


  1. ^ a b "Entrez Gene: ARL1 ADP-ribosylation factor-like 1". 
  2. ^ a b Lu, Lei; Hong Wanjin (September 2003). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Mol. Biol. Cell (United States) 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. ISSN 1059-1524. PMC 196566. PMID 12972563. 
  3. ^ Van Valkenburgh, H; Shern J F; Sharer J D; Zhu X; Kahn R A (June 2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. (United States) 276 (25): 22826–37. doi:10.1074/jbc.M102359200. ISSN 0021-9258. PMID 11303027. 

Further reading[edit]