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Ankyrin repeat and SOCS box containing 2
Symbols ASB2 ; ASB-2
External IDs OMIM605759 MGI1929743 HomoloGene69202 GeneCards: ASB2 Gene
RNA expression pattern
PBB GE ASB2 gnf1h00212 at tn.png
More reference expression data
Species Human Mouse
Entrez 51676 65256
Ensembl ENSG00000100628 ENSMUSG00000021200
UniProt Q96Q27 Q8K0L0
RefSeq (mRNA) NM_001202429 NM_023049
RefSeq (protein) NP_001189358 NP_075536
Location (UCSC) Chr 14:
94.4 – 94.44 Mb
Chr 12:
103.32 – 103.36 Mb
PubMed search [1] [2]

Ankyrin repeat and SOCS box protein 2 is a protein that in humans is encoded by the ASB2 gene.[1]

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.[1]


Further reading[edit]