In 2000, Trigiani wrote a novel about the town titled Big Stone Gap, based on a screenplay by the same name she authored. It was followed by three sequels, Big Cherry Holler,Milk Glass Moon, and Home to Big Stone Gap. Aside from that series, she has written Rococo,Queen of the Big Time, and Lucia, Lucia, which became a best-seller in Britain.Very Valentine, was published in February 2009, and followed by Brava Valentine Valentine in 2010.
She also co-authored "Cooking With My Sisters: One Hundred Years of Family Recipes" with Mary Trigiani, her sister. The family memoir-meets-cookbook includes the contributions of their three sisters and their mother.