|β-Aescin (main component)|
|Jmol-3D images||Image 1|
|Molar mass||1,131.26 g mol−1|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)|
|(what is: / ?)|
Aescin or escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum (the horse chestnut). Aescin is the main active compound in horse chestnut, and is responsible for most of its medicinal properties.
High-quality evidence suggests aescin is a safe and effective treatment for chronic venous insufficiency. In one randomized controlled trial, horse chestnut extract was found to be as effective and well-tolerated as use of compression stockings.
Mechanism of action
Aescin appears to produce effects through a wide range of mechanisms. It induces endothelial nitric oxide synthesis by making endothelial cells more permeable to calcium ions, and also induces release of prostaglandin F2α. Other possible mechanisms include serotonin antagonism and histamine antagonism and reduced catabolism of tissue mucopolysaccharides.
- Sirtori CR (September 2001). "Aescin: pharmacology, pharmacokinetics and therapeutic profile". Pharmacol. Res. 44 (3): 183–193. doi:10.1006/phrs.2001.0847. PMID 11529685.
- Pittler MH, Ernst E (2006). Pittler, Max H, ed. "Horse chestnut seed extract for chronic venous insufficiency". Cochrane Database Syst Rev (1): CD003230. doi:10.1002/14651858.CD003230.pub3. PMID 16437450.
- Diehm C, Trampisch HJ, Lange S, Schmidt C (February 1996). "Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency". Lancet 347 (8997): 292–294. doi:10.1016/S0140-6736(96)90467-5. PMID 8569363.
- Carrasco OF, Vidrio H (July 2007). "Endothelium protectant and contractile effects of the antivaricose principle escin in rat aorta". Vascul. Pharmacol. 47 (1): 68–73. doi:10.1016/j.vph.2007.04.003. PMID 17512261.
- Berti F, Omini C, Longiave D (August 1977). "The mode of action of aescin and the release of prostaglandins". Prostaglandins 14 (2): 241–249. doi:10.1016/0090-6980(77)90169-1. PMID 897216.