Allan Maxam

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Allan Maxam
Born October 28, 1942
Doctoral advisor Walter Gilbert
Known for DNA sequencing

Allan Maxam is one of the pioneers of molecular genetics. He was one of the contributors to develop a DNA sequencing method at Harvard University, while working as a student in the laboratory of Walter Gilbert.[1][2]

Walter Gilbert and Allan Maxam developed a DNA sequencing method which combined chemicals that cut DNA only at specific bases with radioactive labeling and Southern blotting to determine the sequence of long DNA segments.[3]

References[edit]

  1. ^ Maxam, A M; Gilbert, W (1977), "A new method for sequencing DNA.", Proc. Natl. Acad. Sci. U.S.A. (Feb 1977) 74 (2): 560–4, doi:10.1073/pnas.74.2.560, PMC 392330, PMID 265521 
  2. ^ DNA SEQUENCING AND GENE STRUCTURE, Walter Gilbert Nobel lecture, 8 December, 1980
  3. ^ Maxam AM, Gilbert W, Sequencing end-labeled DNA with base-specific chemical cleavages, Methods Enzymol. 1980;65(1):499-560
  • Gilbert, Walter and Maxam. Allan, The Nuclcotide Sequence of the Lac Operator, Proc. Natl. Acad. Sci. USA 70, 3581-3584 (1973).
  • Maxam AM, Tizard R, Skryabin KG, Gilbert W, Promotor region for yeast 5S ribosomal RNA, Nature. 1977 June 16;267(5612):643-5

See also[edit]