Antennapedia

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The mutation Antennapedia

Antennapedia is a HOM-C gene first discovered in Drosophila which controls the formation of legs during development. Loss-of-function mutations in the regulatory region of this gene result in the development of the second leg pair into ectopic antennae. By contrast gain-of-function alleles convert antennae into ectopic legs.

This is just one illustration of the tendency of organisms to exhibit variations on a theme, modulated repetition. Legs and antennae are related to one another as much as molars are to incisors, fingers are to toes, and arms are to legs.

Antennapedia also refers to a gene complex in Drosophila which is responsible for formation and differentiation of the thoracic and head segments of the fly's body.

Recent studies have observed that down-regulation of the Antp gene in Achaearanea tepidariorum leads to the development of a pair of ectopic legs, resulting in 10-legged mutant spiders. [1]

References[edit]

  1. ^ Sara Khadjeh, Natascha Turetzek, Matthias Pechmann, Evelyn E. Schwager, Ernst A. Wimmer, Wim G. M. Damen, and Nikola-Michael Prpic Divergent role of the Hox gene Antennapedia in spiders is responsible for the convergent evolution of abdominal limb repression PNAS 2012 109 (13) 4921-4926; published ahead of print March 15, 2012, doi:10.1073/pnas.1116421109

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External links[edit]

  • ^ Sara Khadjeh, Natascha Turetzek, Matthias Pechmann, Evelyn E. Schwager, Ernst A. Wimmer, Wim G. M. Damen, and Nikola-Michael Prpic Divergent role of the Hox gene Antennapedia in spiders is responsible for the convergent evolution of abdominal limb repression PNAS 2012 109 (13) 4921-4926; published ahead of print March 15, 2012, doi:10.1073/pnas.1116421109