Scarpa was born to an impoverished family in the frazione of Lorenzaga, Motta di Livenza, Veneto. An uncle, who was a member of the priesthood, gave him instruction until the age of 15, when he passed the entrance exam for the University of Padua. He was a pupil of Giovanni Battista Morgagni and Marc Antonio Caldani. Under the former, he became doctor of medicine on 19 May 1770; in 1772, he became professor at the University of Modena.
For a time he chose to travel, visiting Holland, France and England. When he returned to Italy, he was made professor of anatomy at the University of Pavia in 1783, on the strong recommendation of Emperor Joseph II. He remained in that post until 1804, when he stepped down to allow his student Santo Fattori to assume the chair.
In May 1791, he was elected a Fellow of the Royal Society on account of being the "Author of some ingenious observations on the Ganglions of the Nerves, on the structure of the organs of hearing and smell, and other subjects of anatomy and Physiology" 
In 1805, Napoleon was made King of Italy. He chose to visit the University of Pavia, upon which he inquired as to the whereabouts of Dr. Scarpa. He was informed that the doctor had been dismissed because of his political opinions and his refusal to take oaths, whereupon Dr. Scarpa was restored to his position as the chair. In 1821, he was elected a foreign member of the Royal Swedish Academy of Sciences.
During his lifetime he became a rich man, acquiring a collection of valuable paintings and living a wealthy lifestyle. He was a confirmed bachelor, and fathered several sons out of wedlock (whom he favored through nepotism). In his career, he earned a reputation for ruthlessness, destroying his enemies and taxing his favorites to their limits. Toward the end of his life, Antonio Scarpa suffered from a stone in his urinary system. This caused an inflammation of his bladder, which resulted in his death. He died in Pavia on 31 October 1832. After his death, his reputation was bitterly attacked, and even marble stones erected in his memory were defaced. After his death, his assistant Carlo Beolchin performed an autopsy which was documented in an extremely detailed report. As an incredible and questionable[according to whom?] act of homage to the great scientist, the head of the anatomist was removed and exhibited in the Institute of Anatomy. The head is still exhibited at the Museo per la storia dell'Università di Pavia.
Dr. Scarpa published a number of medical treatises that were widely respected.
- De structura fenestrae rotundae auris et de tympano secundario, anatomicae observationes, his first published work, focused on the structure of the inner ear. It was printed in 1772, shortly after he joined the University of Modena.
- In 1789 he published Anatomicæ disquisitiones de auditu et olfactu, a study of the hearing and olfactory organs, which was soon considered a classical treatise on the subject.
- He published Tabulae neurologicae in 1794, which was the first work to give an accurate depiction of the Heart's nerves and to show cardiac innervation. It is considered to be his finest work. Apparently Dr. Scarpa locked the engraver in his room until the illustrations were finished. This work included his discovery that the inner ear was filled with fluid. (This was later named Scarpa's fluid, and subsequently endolymph.)
- Commentarius de Penitiori Ossium Structura, 1799, described the cellular structure of bone, along with notes on growth and diseases of bone.
- His 1801 work, Saggio di osservazioni e d’esperienze sulle principali malattie degli occhi (A Treatise on the Principal Diseases of the Eyes) described and illustrated the major eye diseases. It was the first ophthalmology text published in Italian, but was subsequently published in several languages and earned him the title of "father of Italian ophthalmology".
- Riflessioni ed Osservazione anatomico-chirugiche sull' Aneurisma, 1804, is a classical work on Aneurysms.
- Sull'ernie memorie anatomico-chirurgiche in 1809 was a treatise on the hernia. The supplement work, Sull'ernie del perineo the first ever discussion of the perineal hernia. Traité pratique des hernie, ou, Mémoires anatomiques et chirurgicaux sur ces maladies in 1812, was an authoritative work on the hernia. Both Scarpa's fascia and Scarpa's triangle were derived from these works.
- Scarpa's fascia
- Scarpa's fluid
- Scarpa's foramina
- Scarpa's ganglion
- Scarpa's hiatus
- Scarpa's membrane
- Scarpa's sheath
- Scarpa's shoe
- Scarpa's staphyloma
- Scarpa's triangle
- Rutkow, Ira M. (1988). Great Ideas in the History of Surgery. Norman Publishing. ISBN 0-930405-02-1.
- Richardson, Benjamin Ward (1886). "Antonio Scarpa, F.R.S., and Surgical Anatomy". The Asclepiad (Longmans, Green and Company) 4 (16): 128–157. Retrieved 2008-06-10.
- "Library and Archive Catalogue". The Royal Society. Retrieved 11 October 2010.
- Staff (1833). "Miscellaneous Literary Notes". The Foreign Quarterly Review (Treuttel and Würtz, Treuttel, Jun, and Richter) 11: 252. Retrieved 2008-06-11.
- Momesso, Sergio (2007). La collezione di Antonio Scarpa (1752–1832). Bertoncello Artigrafiche. ISBN 88-86868-24-3.
- Society for the Diffusion of Useful Knowledge (1841). Penny Cyclopaedia, vol. 21. London: C. Knight. p. 16.
- Jahn, Anthony F.; Santos-Sacchi, Joseph (2001). Physiology of the Ear. Thomson Delmar Learning. ISBN 1-56593-994-8.
- Full title: Tabulae nevrologicae ad illustrandam historiam cardiacorum nervorum, noni nervorum cerebri, glossopharingei et pharingei.
- Acierno, Louis J. (1994). The History of Cardiology: Men, Ideas and. Informa Health Care. ISBN 1-85070-339-6.
- Sebastian, Anton (1999). A Dictionary of the History of Medicine. Informa Health Care. ISBN 1-85070-021-4.
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