April 28, 1963 |
|Fields||MedicinalChemistry, Green Chemistry & Drug Discovery|
Central Drug Research Institute
|Alma mater||Lucknow University|
Atul Kumar [ अतुल कुमार् ] (Born, April 28, 1963, Lucknow, India) is a scientist in the Central Drug Research Institute (CDRI) of Lucknow, India. His areas of research are organic chemistry, medicinal chemistry and drug design. He has made significant contributions to research on osteoporosis, cancer, Tuberculosis, diabetes and other metabolic disorders. He also has considerable contributions in the area of organic chemistry particularly in the development of organocatalysed synthesis, Biomimetic synthesis, multicomponent reaction, Green chemistry, sonochemistry, enzymatic synthesis, and diversity oriented synthesis, Functional Ionic Liquid Mediated Synthesis (FILMS).
Education & Profession
Atul Kumar obtained his masters degree and Ph.D from Lucknow University, then worked as a post-doc at the SUNY Buffalo. He is working as a Principal scientist (Srfaculty member) in the department of Medicinal Chemistry at the Central Drug Research Institute in Lucknow, India. He has developed a new drug candidates "CENTHANK" CDRI-99-373,(anti-resorptive agent)for the treatment of osteoporosis which is currently in Phase I clinical trials, diabetes and breast cancer, which are in preclinical stages. In the area of medicinal chemistry, he has some nice contributions such as; he has developed a natural product inspired diversity oriented synthesis of tetrahydroquinoline analogues as antitubercular agents, he has reported pyranocoumarins: a new class of anti-hyperglycemic and anti-dyslipidemic agents, design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agents.
In the area of organic synthesis, he has been involved in the development of new catalysts such as Liposomised mCPBA (LIP-mCPBA), new solid-supported hypervalent iodine reagents, and the use of human hemoglobin (HbA) and supramolecular carbohydrate molecules as solid catalysts for the synthesis of bioactive molecules. He has extensively contributed to the development of organocatalysed synthesis, biomimetic synthesis, multicomponent reaction, sonochemistry, enzymatic synthesis, high-throughput synthesis and diversity oriented synthesis.
Dr. Kumar was the first to demonstrate that single nucleotides have the ability to catalyze organic reactions, and performed biomimetic reductive amination, which is considered as one of the most genuine biomimetric reactions of organic chemistry. This single-nucleotide catalysis has immense impact on many fields of science such as chemistry, biochemistry, and prebiotic studies, especially the RNA world and DNA world hypothesis for understanding the origin of life on Earth.
Dr. Kumar has reported an efficient and conceptually different approach toward C-H bond activation by using iodine mediated sp3 C-H functionalization for the synthesis of alkyl azarene pyridinium zwitterions.
These studies have resulted in publication of about 75 original research papers, and 42 patents.
Awards and honors
Kumar has won several awards for the design, synthesis and discovery of New Chemical Entities (NCEs) for various therapeutic areas associated with women reproductive health (osteoporosis) and metabolic diseases like diabetes & anti cancer.The discovery of anti-osteoporosis agent CDRI-99-373, this drug was also recognized as a "notable Science and technological achievement" by the Government of India Planning Commission in its ``Report of Steering Committee of Science and Technology for the eleventh Five year plan (2007-2012).
He has received several honors and awards, notably the Organization of Pharmaceutical Producers of India (OPPI) OPPI SCIENTIST AWARD 2007. This award is given by Mr. Ram Vilas Paswan, Hon. Minster for Chemical and Fertilizers, Government of India at Mumbai, including R 1,00,000.00 as a cash award, he also received CDRI Incentive Awards for years 2004, 2005, 2006, 2007, 2008, 2009, 2010,2011, 2012 and 2013. Dr. Kumar is a Member of the Global Advisory Council of SCIFINDER / CAS (Chemical Abstracts Service) A division of American Chemical Society (ACS), USA.
Several of his publications in synthetic chemistry and medicinal chemistry have been recognized as distinguish research contributions:
- "Synthesis of Benzimidazoles, Benzoxazoles and Benzothiazoles with PDAIS" (J. Combinatorial Chemistry, 2009) was listed as a distinguished paper in SYNFACT
- His papers published as Tetrahedron Letters 34, 4751, 1996, Tetrahedron Letters 37,3463, 1993 were listed in the "HEART CUT" Column of "CHEM TECH" (ACS Publication) as distinguished papers.
- His work on diabetes has been cited by the "Nature" eMagazine Nature India in its Research highlights.
- His paper on the synthesis of heterocycles using aqueous micelles and ultrasonic irradiation is listed in the Organic Chemistry Portal.
- His paper "β-cyclodextrin catalysed synthesis of Tryptanthrin " has been listed in Top ten most accessed articles of Green Chemistry.*
- His paper "Functional ionic liquid mediated synthesis (FILMS) of dihydrothiophenes and tacrine derivatives" has been listed in Top ten most accessed articles of Green Chemistry.
- His paper "Single Nucleotide-Catalyzed Biomimetic Reductive Amination" has been covered by the "Nature" eMagazine Nature India in its Research highlights "Probing the origin of life".
- "Biodata of Dr. Atul Kumar". Archived from the original on 18 September 2010. Retrieved 15 September 2010.
- CDRI. "Compound CDRI-99/373". Archived from the original on 18 September 2010. Retrieved 15 September 2010., http://www.indianexpress.com/news/cdri-develops-molecule-to-tackle-osteoporosis/528361/2, http://www.cdriindia.org/safety-clinical2.htm
- CDRI (2004), Annual Report 2003-2004
- http://pubs.acs.org/doi/abs/10.1021/co100022h Missing or empty
- http://220.127.116.11/siocl/siocl_0004/090902hhpdf/090923bmcl-2.pdf Missing or empty
- Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agent
- Kumar, Atul; Siddharth Sharma, Ram Awatar Maurya (2010), "Single Nucleotide-Catalyzed Biomimetic Reductive Amination", Advanced Synthesis and Catalyst 352 (13): 2227–2232, doi:10.1002/adsc.201000178.
- Kumar, Atul; Garma Gupta, Sumen Srivastava, (2011), "Synthesis of New Class of Alkyl Azarene Pyridinium Zwitterions via Iodine Mediated sp3 C–H Bond Activation", Organic Letters 13 (24): 6366, doi:10.1021/ol202654j.
- Kumar, Atul; et.al. (2011), "Functional ionic liquid mediated synthesis (FILMS) of dihydrothiophenes and tacrine", Green Chemistry 13: 2459, doi:10.1039/C1GC15410A.
- http://csirindia.wordpress.com/2010/01/09/new-molecule-to-control-sugar-and-protect/.html Missing or empty
- Office of the Principal Scientific Adviser to the Government of India (2006), http://www.dst.gov.in/about_us/11th-plan/rep-s-t.pdf, archived from the original on 21 October 2010, retrieved 15 September 2010 Missing or empty
- Organization of Pharmaceutical Producers of India, http://www.indiaoppi.com/, retrieved 15 September 2010 Missing or empty
- http://www.niscair.res.in/sciencecommunication/.../csirnews_, retrieved 15 September 2010 Missing or empty
- http://www.biospectrumasia.com/Content/181007IND4617.asp Missing or empty
- http://www.cipi.in/news220907pb.htm Missing or empty
- http://www.oasis.csir.res.in/ridlink.aspx Missing or empty
- Kumar, Atul Kumar, R. A. Maurya, P. Ahmad; Maurya, R.; Ahmad, P. (2009), "Synthesis of Benzimidazoles, Benzoxazoles and Benzothiazoles with PDAIS", J. Comb. Chem. 2009 (6): 0691, doi:10.1055/s-0029-1216760.
- http://www.nature.com/nindia/2009/091224/full/nindia.2009.359.html Missing or empty
- A. Kumar, R. A. Maurya (2008), "Efficient Synthesis of Hantzsch Esters and Polyhydroquinoline Derivatives in Aqueous Micelles", Synlett 2008 (6): 883–885, doi:10.1055/s-2008-1042908.
- http://blogs.rsc.org/gc/2011/01/28/top-ten-most-accessed-articles-in-december/ Missing or empty
- Top ten most accessed articles in September url= http://blogs.rsc.org/gc/2011/10/20/top-ten-most-accessed-articles-in-september-2/
- Probing the origin of life=url=http://www.nature.com/nindia/2010/100929/full/nindia.2010.132.html
- Probing the origin of life url=http://www.nature.com/nindia/index.html