BCL9L

BCL9L
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XB1, 4UP0, 4UP5
Identifiers
Aliases	BCL9L, BCL9-2, DLNB11, B-cell CLL/lymphoma 9-like, B-cell CLL/lymphoma 9 like, B cell CLL/lymphoma 9 like, B9L, BCL9 like
External IDs	OMIM: 609004; MGI: 1933114; HomoloGene: 65615; GeneCards: BCL9L; OMA:BCL9L - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,925,926 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,423,193 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right coronary artery; ; stromal cell of endometrium; ; right uterine tube; ; gastric mucosa; ; popliteal artery; ; tibial arteries; ; mucosa of ileum; ; right ovary; ; nipple;
	Top expressed in
	basilar part of occipital bone; ; splanchnocranium; ; sphenoid bone; ; thyroid cartilage; ; basisphenoid; ; Meckel's cartilage; ; rib; ; lip; ; hyoid bone; ; Rostral migratory stream;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coactivator activity; beta-catenin binding;
Cellular component	nucleolus; nucleus; nucleoplasm; beta-catenin-TCF complex;
Biological process	regulation of cell morphogenesis; regulation of transcription, DNA-templated; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of epithelial to mesenchymal transition; transcription, DNA-templated; beta-catenin-TCF complex assembly; canonical Wnt signaling pathway; somatic stem cell population maintenance; skeletal muscle cell differentiation; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	283149
	80288
	ENSG00000186174
	ENSMUSG00000063382
	Q86UU0
	Q67FY2
	NM_182557; NM_001378213; NM_001378214
	NM_030256; NM_001357490
	NP_872363; NP_001365142; NP_001365143
	NP_084532; NP_001344419
	Wikidata
View/Edit Human	View/Edit Mouse

B-cell CLL/lymphoma 9 like is a protein that in humans is encoded by the BCL9L gene. ^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186174 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063382 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: B-cell CLL/lymphoma 9 like". Retrieved 2017-10-31.

Sampietro J, Dahlberg CL, Cho US, Hinds TR, Kimelman D, Xu W (2006). "Crystal structure of a beta-catenin/BCL9/Tcf4 complex". Mol. Cell. 24 (2): 293–300. doi:10.1016/j.molcel.2006.09.001. PMID 17052462.
Miller TC, Rutherford TJ, Johnson CM, Fiedler M, Bienz M (2010). "Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor". J. Mol. Biol. 401 (5): 969–84. doi:10.1016/j.jmb.2010.07.007. PMC 2927781. PMID 20637214.
Brembeck FH, Wiese M, Zatula N, Grigoryan T, Dai Y, Fritzmann J, Birchmeier W (2011). "BCL9-2 promotes early stages of intestinal tumor progression". Gastroenterology. 141 (4): 1359–70, 1370.e1–3. doi:10.1053/j.gastro.2011.06.039. PMID 21703997.
Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A, Aburatani H, Nakamura T, Akiyama T (2011). "Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway". Nat Commun. 2: 548. doi:10.1038/ncomms1551. PMID 22109522.
Zatula N, Wiese M, Bunzendahl J, Birchmeier W, Perske C, Bleckmann A, Brembeck FH (2014). "The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis". Oncotarget. 5 (16): 6770–87. doi:10.18632/oncotarget.2252. PMC 4196162. PMID 25149534.
El-Hage P, Petitalot A, Monsoro-Burq AH, Maczkowiak F, Driouch K, Formstecher E, Camonis J, Sabbah M, Bièche I, Lidereau R, Lallemand F (2015). "The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells". Mol. Cancer Res. 13 (5): 902–12. doi:10.1158/1541-7786.MCR-14-0180. PMID 25678599.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186174 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063382 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: B-cell CLL/lymphoma 9 like". Retrieved 2017-10-31.

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References

Further reading