BolA-like protein family

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PDB 1ny8 EBI.jpg
solution structure of protein yrba from escherichia coli: northeast structural genomics consortium target er115
Symbol BolA
Pfam PF01722
InterPro IPR002634
SCOP 1v9j

In molecular biology, the BolA-like protein family consists of the morpho-protein BolA from Escherichia coli and its various homologs. In E. coli, over-expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division.[1] The expression of BolA is growth rate regulated and is induced during the transition into the stationary phase.[1] BolA is also induced by stress during early stages of growth [1] and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.[1][2]


  1. ^ a b c d Santos JM, Freire P, Vicente M, Arraiano CM (May 1999). "The stationary-phase morphogene bolA from Escherichia coli is induced by stress during early stages of growth". Mol. Microbiol. 32 (4): 789–98. doi:10.1046/j.1365-2958.1999.01397.x. PMID 10361282. 
  2. ^ Aldea M, Garrido T, Hernandez-Chico C, Vicente M, Kushner SR (December 1989). "Induction of a growth-phase-dependent promoter triggers transcription of bolA, an Escherichia coli morphogene". EMBO J. 8 (12): 3923–31. PMC 402084. PMID 2684651. 

This article incorporates text from the public domain Pfam and InterPro IPR002634