Brainshuttle

Brainshuttle or brain shuttle is a technology developed by Roche to help molecules such as monoclonal antibodies to cross the blood-brain barrier more than they would otherwise. It has been tested with anti-amyloid monoclonal antibodies such as trontinemab.^[1]^[2]^[3]^[4]^[5]^[6]

References

^ Ruderisch, Nadine; Schlatter, Daniel; Kuglstatter, Andreas; Guba, Wolfgang; Huber, Sylwia; Cusulin, Carlo; Benz, Jörg; Rufer, Arne Christian; Hoernschemeyer, Joerg; Schweitzer, Christophe; Bülau, Tina; Gärtner, Achim; Hoffmann, Eike; Niewoehner, Jens; Patsch, Christoph; Baumann, Karlheinz; Loetscher, Hansruedi; Kitas, Eric; Freskgård, Per-Ola (October 2017). "Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport". eBioMedicine. 24: 76–92. doi:10.1016/j.ebiom.2017.09.004. PMC 5652008.
^ Morito, Takahiro; Harada, Ryuichi; Iwata, Ren; Du, Yiqing; Okamura, Nobuyuki; Kudo, Yukitsuka; Yanai, Kazuhiko (28 January 2021). "Synthesis and pharmacokinetic characterisation of a fluorine-18 labelled brain shuttle peptide fusion dimeric affibody". Scientific Reports. 11 (1): 2588. doi:10.1038/s41598-021-82037-2. ISSN 2045-2322. PMC 7844286.
^ Campos, Christopher R.; Kemble, Alicia M.; Niewoehner, Jens; Freskgård, Per-Ola; Urich, Eduard (10 March 2020). "Brain Shuttle Neprilysin reduces central Amyloid-β levels". PLOS ONE. 15 (3): e0229850. doi:10.1371/journal.pone.0229850. ISSN 1932-6203. PMC 7064168.
^ Hultqvist, Greta; Syvänen, Stina; Fang, Xiaotian T.; Lannfelt, Lars; Sehlin, Dag (2017). "Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor". Theranostics. 7 (2): 308–318. doi:10.7150/thno.17155. PMC 5197066. PMID 28042336.
^ Grimm, Hans Peter; Schumacher, Vanessa; Schäfer, Martin; Imhof-Jung, Sabine; Freskgård, Per-Ola; Brady, Kevin; Hofmann, Carsten; Rüger, Petra; Schlothauer, Tilman; Göpfert, Ulrich; Hartl, Maximilian; Rottach, Sylvia; Zwick, Adrian; Seger, Shanon; Neff, Rachel; Niewoehner, Jens; Janssen, Niels (2023). "Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans". mAbs. 15 (1): 2261509. doi:10.1080/19420862.2023.2261509. ISSN 1942-0870. PMC 10572082. PMID 37823690.
^ Kulic, Luka; Vogt, Annamarie; Alcaraz, Fabien; Barrington, Philip; Marchesi, Maddalena; Klein, Gregory; Croney, Ruth; Agnew, David; Abrantes, João A.; Svoboda, Hanno (1 September 2022). "053 Brainshuttle AD: Investigating safety, tolerability, and PK/PD of RG6102 in prodromal/mild-to-moderate AD". Journal of Neurology, Neurosurgery & Psychiatry. 93 (9): e2. doi:10.1136/jnnp-2022-abn2.97. ISSN 0022-3050.

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[1] Ruderisch, Nadine; Schlatter, Daniel; Kuglstatter, Andreas; Guba, Wolfgang; Huber, Sylwia; Cusulin, Carlo; Benz, Jörg; Rufer, Arne Christian; Hoernschemeyer, Joerg; Schweitzer, Christophe; Bülau, Tina; Gärtner, Achim; Hoffmann, Eike; Niewoehner, Jens; Patsch, Christoph; Baumann, Karlheinz; Loetscher, Hansruedi; Kitas, Eric; Freskgård, Per-Ola (October 2017). "Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport". eBioMedicine. 24: 76–92. doi:10.1016/j.ebiom.2017.09.004. PMC 5652008.

[2] Morito, Takahiro; Harada, Ryuichi; Iwata, Ren; Du, Yiqing; Okamura, Nobuyuki; Kudo, Yukitsuka; Yanai, Kazuhiko (28 January 2021). "Synthesis and pharmacokinetic characterisation of a fluorine-18 labelled brain shuttle peptide fusion dimeric affibody". Scientific Reports. 11 (1): 2588. doi:10.1038/s41598-021-82037-2. ISSN 2045-2322. PMC 7844286.

[3] Campos, Christopher R.; Kemble, Alicia M.; Niewoehner, Jens; Freskgård, Per-Ola; Urich, Eduard (10 March 2020). "Brain Shuttle Neprilysin reduces central Amyloid-β levels". PLOS ONE. 15 (3): e0229850. doi:10.1371/journal.pone.0229850. ISSN 1932-6203. PMC 7064168.

[4] Hultqvist, Greta; Syvänen, Stina; Fang, Xiaotian T.; Lannfelt, Lars; Sehlin, Dag (2017). "Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor". Theranostics. 7 (2): 308–318. doi:10.7150/thno.17155. PMC 5197066. PMID 28042336.

[5] Grimm, Hans Peter; Schumacher, Vanessa; Schäfer, Martin; Imhof-Jung, Sabine; Freskgård, Per-Ola; Brady, Kevin; Hofmann, Carsten; Rüger, Petra; Schlothauer, Tilman; Göpfert, Ulrich; Hartl, Maximilian; Rottach, Sylvia; Zwick, Adrian; Seger, Shanon; Neff, Rachel; Niewoehner, Jens; Janssen, Niels (2023). "Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans". mAbs. 15 (1): 2261509. doi:10.1080/19420862.2023.2261509. ISSN 1942-0870. PMC 10572082. PMID 37823690.

[6] Kulic, Luka; Vogt, Annamarie; Alcaraz, Fabien; Barrington, Philip; Marchesi, Maddalena; Klein, Gregory; Croney, Ruth; Agnew, David; Abrantes, João A.; Svoboda, Hanno (1 September 2022). "053 Brainshuttle AD: Investigating safety, tolerability, and PK/PD of RG6102 in prodromal/mild-to-moderate AD". Journal of Neurology, Neurosurgery & Psychiatry. 93 (9): e2. doi:10.1136/jnnp-2022-abn2.97. ISSN 0022-3050.

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