CKM (gene)

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Creatine kinase, muscle
CK1I0E.png
Crystallographic structure of human creatine kinase isolated from muscle.[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CKM ; CKMM; M-CK
External IDs OMIM123310 MGI88413 HomoloGene20432 ChEMBL: 2656 GeneCards: CKM Gene
EC number 2.7.3.2
Orthologs
Species Human Mouse
Entrez 1158 12715
Ensembl ENSG00000104879 ENSMUSG00000030399
UniProt P06732 P07310
RefSeq (mRNA) NM_001824 NM_007710
RefSeq (protein) NP_001815 NP_031736
Location (UCSC) Chr 19:
45.81 – 45.83 Mb
Chr 7:
19.41 – 19.42 Mb
PubMed search [1] [2]


Creatine kinase, muscle also known as CKM is a creatine kinase that in humans is encoded by the CKM gene.[2]

Structure[edit]

In the figure to the right, the crystal structure of the muscle-type M-CK monomer is shown. In vivo, two such monomers arrange symmetrically to form the active MM-CK enzyme.

Function[edit]

The protein encoded by this gene is a cytoplasmic enzyme involved in cellular energy homeostasis. The encoded protein reversibly catalyzes the transfer of "energy-rich" phosphate between ATP and creatine and between phospho-creatine and ADP. Its functional entity is a MM-CK homodimer in striated (sarcomeric) skeletal and cardiac muscle.

Clinical significance[edit]

In heart, in addition to the MM-CK homodimer also the heterodimer consisting of one muscle (MM-CK) and one brain-type (MB-CK) subunit is expressed. This latter is an important serum marker for myocardial infarction, for it is released from damaged myocardial cells into the blood where it can be detected by clinical chemistry. Since no other organ than cardiac muscle expresses significant levels of MB-CK, this clinical test is still fairly reliable, together with troponin-T, for diagnosing a myocardial infarction.[3]

References[edit]

  1. ^ PDB 1I0E; Shen YQ, Tang L, Zhou HM, Lin ZJ (August 2001). "Structure of human muscle creatine kinase". Acta Crystallogr. D Biol. Crystallogr. 57 (Pt 8): 1196–200. doi:10.1107/S0907444901007703. PMID 11517911. 
  2. ^ Rosenberg UB, Kunz G, Frischauf A, Lehrach H, Mähr R, Eppenberger HM, Perriard JC (November 1982). "Molecular cloning and expression during myogenesis of sequences coding for M-creatine kinase". Proc. Natl. Acad. Sci. U.S.A. 79 (21): 6589–92. doi:10.1073/pnas.79.21.6589. PMC 347173. PMID 6959139. 
  3. ^ "Entrez Gene: CKM". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.