CLDN11

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Claudin 11
Identifiers
Symbols CLDN11 ; OSP; OTM
External IDs OMIM601326 MGI106925 HomoloGene4093 GeneCards: CLDN11 Gene
RNA expression pattern
PBB GE CLDN11 206908 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5010 18417
Ensembl ENSG00000013297 ENSMUSG00000037625
UniProt O75508 Q60771
RefSeq (mRNA) NM_001185056 NM_008770
RefSeq (protein) NP_001171985 NP_032796
Location (UCSC) Chr 3:
170.14 – 170.58 Mb
Chr 3:
31.15 – 31.16 Mb
PubMed search [1] [2]

Claudin-11 is a protein that in humans is encoded by the CLDN11 gene.[1][2][3] It belongs to the group of claudins.

The protein encoded by this gene belongs to the claudin family of tight junction associated proteins and is a major component of central nervous system myelin that is necessary for normal CNS function. There is growing evidence that the protein determines the permeability between layers of myelin sheaths via focal adhesion and, with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.[3]

References[edit]

  1. ^ Bronstein JM, Kozak CA, Chen XN, Wu S, Danciger M, Korenberg JR, Farber DB (Feb 1997). "Chromosomal localization of murine and human oligodendrocyte-specific protein genes". Genomics 34 (2): 255–7. doi:10.1006/geno.1996.0278. PMID 8661061. 
  2. ^ Bronstein JM, Popper P, Micevych PE, Farber DB (Nov 1996). "Isolation and characterization of a novel oligodendrocyte-specific protein". Neurology 47 (3): 772–8. doi:10.1212/wnl.47.3.772. PMID 8797478. 
  3. ^ a b "Entrez Gene: CLDN11 claudin 11 (oligodendrocyte transmembrane protein)". 

Further reading[edit]