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CDC-like kinase 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CLK2 ; hCLK2
External IDs OMIM602989 MGI1098669 HomoloGene33303 ChEMBL: 4225 GeneCards: CLK2 Gene
EC number
RNA expression pattern
PBB GE CLK2 203229 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1196 12748
Ensembl ENSG00000176444 ENSMUSG00000068917
UniProt P49760 O35491
RefSeq (mRNA) NM_001291 NM_001163432
RefSeq (protein) NP_001281267 NP_001156904
Location (UCSC) Chr 1:
155.23 – 155.25 Mb
Chr 3:
89.16 – 89.18 Mb
PubMed search [1] [2]

Dual specificity protein kinase CLK2 is an enzyme that in humans is encoded by the CLK2 gene.[1][2][3]

This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have shown to interact with, and phosphorylate, serine/arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. This protein kinase is involved in the regulation of several cellular processes and may serve as a link between cell cycle progression, apoptosis, and telomere length regulation.[3]


  1. ^ Hanes J, von der Kammer H, Klaudiny J, Scheit KH (Jan 1995). "Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases". J Mol Biol 244 (5): 665–72. doi:10.1006/jmbi.1994.1763. PMID 7990150. 
  2. ^ Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L (Dec 1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum Genet 103 (4): 523–4. doi:10.1007/s004390050861. PMID 9856501. 
  3. ^ a b "Entrez Gene: CLK2 CDC-like kinase 2". 

Further reading[edit]