CLPTM1L

CLPTM1L
Identifiers
Aliases	CLPTM1L, CRR9, CLPTM1-like, CLPTM1 like
External IDs	OMIM: 612585 MGI: 2442892 HomoloGene: 12767 GeneCards: CLPTM1L
Gene location (Human) Chr. Chromosome 5 (human) Band 5p15.33 Start 1,317,752 bp End 1,345,099 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 C1 Start 73,752,125 bp End 73,768,724 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland body of pancreas left lobe of thyroid gland oocyte upper lobe of left lung secondary oocyte right lobe of liver body of stomach right lung minor salivary glands Top expressed in lacrimal gland salivary gland submandibular gland seminal vesicula parotid gland calvaria crypt of lieberkuhn of small intestine medullary collecting duct islet of Langerhans epithelium of stomach More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 81037 218335 Ensembl ENSG00000049656 ENSG00000274811 ENSMUSG00000021610 UniProt Q96KA5 Q8BXA5 RefSeq (mRNA) NM_030782 NM_146047 RefSeq (protein) NP_110409 NP_666159 Location (UCSC) Chr 5: 1.32 – 1.35 Mb Chr 13: 73.75 – 73.77 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein), also known as cisplatin resistance-related protein 9 (CRR9p), is a protein that in humans is encoded by the CLPTM1L gene. CRR9p is associated with cisplatin-induced apoptosis. CLPTM1L, which lies within a cancer susceptibility locus on chromosome 5 (5p15.33), has been found to be commonly over-expressed in lung tumors and to confer resistance to apoptosis caused by genotoxic agents in association with up-regulation of the anti-apoptotic protein, Bcl-xL. Inhibition of CLPTM1L has been shown to inhibit oncogenic transformation and tumorigenesis caused by the KRas oncogene partially through the PI3K/Akt survival signaling axis.

See also

• Cleft lip and palate transmembrane protein 1

External links

• Human CLPTM1L genome location and CLPTM1L gene details page in the UCSC Genome Browser.

Further reading

• Truong T, Hung RJ, Amos CI, Wu X, Bickeböller H, Rosenberger A, Sauter W, Illig T, Wichmann HE, Risch A, Dienemann H, Kaaks R, Yang P, Jiang R, Wiencke JK, Wrensch M, Hansen H, Kelsey KT, Matsuo K, Tajima K, Schwartz AG, Wenzlaff A, Seow A, Ying C, Staratschek-Jox A, Nürnberg P, Stoelben E, Wolf J, Lazarus P, Muscat JE, Gallagher CJ, Zienolddiny S, Haugen A, van der Heijden HF, Kiemeney LA, Isla D, Mayordomo JI, Rafnar T, Stefansson K, Zhang ZF, Chang SC, Kim JH, Hong YC, Duell EJ, Andrew AS, Lejbkowicz F, Rennert G, Müller H, Brenner H, Le Marchand L, Benhamou S, Bouchardy C, Teare MD, Xue X, McLaughlin J, Liu G, McKay JD, Brennan P, Spitz MR (2010). "Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium". J. Natl. Cancer Inst. 102 (13): 959–71. doi:10.1093/jnci/djq178. PMC 2897877. PMID 20548021.
• McKay JD, Hung RJ, Gaborieau V, Boffetta P, Chabrier A, Byrnes G, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, McLaughlin J, Shepherd F, Montpetit A, Narod S, Krokan HE, Skorpen F, Elvestad MB, Vatten L, Njølstad I, Axelsson T, Chen C, Goodman G, Barnett M, Loomis MM, Lubiñski J, Matyjasik J, Lener M, Oszutowska D, Field J, Liloglou T, Xinarianos G, Cassidy A, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, González CA, Ramón Quirós J, Martínez C, Navarro C, Ardanaz E, Larrañaga N, Kham KT, Key T, Bueno-de-Mesquita HB, Peeters PH, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tjønneland A, Kumle M, Riboli E, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P (2008). "Lung cancer susceptibility locus at 5p15.33". Nat. Genet. 40 (12): 1404–6. doi:10.1038/ng.254. PMC 2748187. PMID 18978790.
• Wang Y, Broderick P, Matakidou A, Eisen T, Houlston RS (2010). "Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers". Carcinogenesis. 31 (2): 234–8. doi:10.1093/carcin/bgp287. PMID 19955392.
• Wang Y, Broderick P, Webb E, Wu X, Vijayakrishnan J, Matakidou A, Qureshi M, Dong Q, Gu X, Chen WV, Spitz MR, Eisen T, Amos CI, Houlston RS (2008). "Common 5p15.33 and 6p21.33 variants influence lung cancer risk". Nat. Genet. 40 (12): 1407–9. doi:10.1038/ng.273. PMC 2695928. PMID 18978787.
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• Broderick P, Wang Y, Vijayakrishnan J, Matakidou A, Spitz MR, Eisen T, Amos CI, Houlston RS (2009). "Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study". Cancer Res. 69 (16): 6633–41. doi:10.1158/0008-5472.CAN-09-0680. PMC 2754318. PMID 19654303.
• Liu Z, Li G, Wei S, Niu J, Wang LE, Sturgis EM, Wei Q (2010). "Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck". Carcinogenesis. 31 (11): 1977–1981. doi:10.1093/carcin/bgq179. PMC 2966556. PMID 20802237.
• Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, Jacobs KB, Arslan AA, Bueno-de-Mesquita HB, Gallinger S, Gross M, Helzlsouer K, Holly EA, Jacobs EJ, Klein AP, LaCroix A, Li D, Mandelson MT, Olson SH, Risch HA, Zheng W, Albanes D, Bamlet WR, Berg CD, Boutron-Ruault MC, Buring JE, Bracci PM, Canzian F, Clipp S, Cotterchio M, de Andrade M, Duell EJ, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hankinson SE, Hassan M, Howard B, Hunter DJ, Hutchinson A, Jenab M, Kaaks R, Kooperberg C, Krogh V, Kurtz RC, Lynch SM, McWilliams RR, Mendelsohn JB, Michaud DS, Parikh H, Patel AV, Peeters PH, Rajkovic A, Riboli E, Rodriguez L, Seminara D, Shu XO, Thomas G, Tjønneland A, Tobias GS, Trichopoulos D, Van Den Eeden SK, Virtamo J, Wactawski-Wende J, Wang Z, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Fraumeni JF, Hoover RN, Hartge P, Chanock SJ (2010). "A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33". Nat. Genet. 42 (3): 224–8. doi:10.1038/ng.522. PMC 2853179. PMID 20101243.
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