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COP9 signalosome subunit 2
Symbols COPS2 ; ALIEN; CSN2; SGN2; TRIP15
External IDs OMIM604508 MGI1330276 HomoloGene134283 GeneCards: COPS2 Gene
RNA expression pattern
PBB GE COPS2 202467 s at tn.png
PBB GE COPS2 209838 at tn.png
More reference expression data
Species Human Mouse
Entrez 9318 12848
Ensembl ENSG00000166200 ENSMUSG00000027206
UniProt P61201 P61202
RefSeq (mRNA) NM_001143887 NM_009939
RefSeq (protein) NP_001137359 NP_034069
Location (UCSC) Chr 15:
49.4 – 49.45 Mb
Chr 2:
125.83 – 125.86 Mb
PubMed search [1] [2]

COP9 signalosome complex subunit 2 is a protein that in humans is encoded by the COPS2 gene.[1][2][3]


COPS2 has been shown to interact with IRF8,[4] NIF3L1,[5] Thyroid hormone receptor alpha[6] and DAX1.[7]


  1. ^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974. 
  2. ^ Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (April 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J 12 (6): 469–78. PMID 9535219. 
  3. ^ "Entrez Gene: COPS2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)". 
  4. ^ Cohen, H; Azriel A; Cohen T; Meraro D; Hashmueli S; Bech-Otschir D; Kraft R; Dubiel W; Levi B Z (December 2000). "Interaction between Interferon Consensus Sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome". J. Biol. Chem. (UNITED STATES) 275 (50): 39081–9. doi:10.1074/jbc.M004900200. ISSN 0021-9258. PMID 10991940. 
  5. ^ Akiyama, Hirotada; Fujisawa Naoko; Tashiro Yousuke; Takanabe Natsuko; Sugiyama Akinori; Tashiro Fumio (March 2003). "The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2". J. Biol. Chem. (United States) 278 (12): 10752–62. doi:10.1074/jbc.M209856200. ISSN 0021-9258. PMID 12522100. 
  6. ^ Dressel, U; Thormeyer D; Altincicek B; Paululat A; Eggert M; Schneider S; Tenbaum S P; Renkawitz R; Baniahmad A (May 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Mol. Cell. Biol. (UNITED STATES) 19 (5): 3383–94. ISSN 0270-7306. PMC 84131. PMID 10207062. 
  7. ^ Altincicek, B; Tenbaum S P; Dressel U; Thormeyer D; Renkawitz R; Baniahmad A (March 2000). "Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita". J. Biol. Chem. (UNITED STATES) 275 (11): 7662–7. doi:10.1074/jbc.275.11.7662. ISSN 0021-9258. PMID 10713076. 

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